S-Ethyl-Isothiocitrullin-Based Dipeptides and 1,2,4-Oxadiazole Pseudo-Dipeptides: Solid Phase Synthesis and Evaluation as NO Synthase Inhibitors

Autor: Hernandez, Elodie Mauchauffée, Jérémy Leroy, Jihanne Chamcham, Abdelaziz Ejjoummany, Manon Maurel, Lionel Nauton, Booma Ramassamy, Karima Mezghenna, Jean-Luc Boucher, Anne-Dominique Lajoix, Jean-François

Publikováno v: Molecules; Volume 28; Issue 13; Pages: 5085

We previously reported dipeptidomimetic compounds as inhibitors of neuronal and/or inducible NO synthases (n/iNOS) with significant selectivity against endothelial NOS (eNOS). They were composed of an S-ethylisothiocitrullin-like moiety linked to an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=multidiscipl::4256ce4966bbb6b3902c333f54726652

Synthesis, Characterization and NO Synthase Inhibition Testing of 2-Aryl-5-aroyl-3,4,5,6-tetrahydropyrimidinium Chlorides

Autor: Booma Ramassamy, Dieter Heber, Ulrich Girreser, Ulrich Wolschendorf, Ullvi Bluhm, Bernd Clement, Jean-Luc Boucher

Publikováno v: Journal of Heterocyclic Chemistry. 52:24-39

Aryl methyl ketones can be easily converted to 1-aryl-2-dimethylaminomethylpropenones that are known as interesting lead structures for drug development. By reaction of these enone Mannich bases with benzamidines, a series of new 2-aryl-5-aroyl-3,4,5

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::92c6b0e0d2c9ad443efa7f832686ae28
https://doi.org/10.1002/jhet.1925

Rational design of a fluorescent NADPH derivative imaging constitutive nitric-oxide synthases upon two-photon excitation

Autor: Booma Ramassamy, Patrick Tauc, Huan Wang, Hamid Dhimane, Yun Li, Chantal Dessy, Laurence Morellato, Vladimir Berka, Ah-Lim Tsai, Bogdan Tarus, Etienne Henry, Anny Slama-Schwok, Eric Deprez, Jean Luc Boucher, Miguel Romero Perez

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, 2012, 109 (31), pp.12526-31. ⟨10.1073/pnas.1205645109⟩
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2012, 109 (31), pp.12526-31. ⟨10.1073/pnas.1205645109⟩
Proceedings of the National Academy of Sciences of the United States of America 31 (109), 12526-31. (2012)
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2012, 109 (31), pp.12526-31. 〈10.1073/pnas.1205645109〉
Proceedings of the National academy of sciences of the United States of America, Vol. 109, no. 31, p. 12526-12531 (2012)

International audience; We report the structure-based design and synthesis of a unique NOS inhibitor, called nanoshutter NS1, with two-photon absorption properties. NS1 targets the NADPH site of NOS by a nucleotide moiety mimicking NADPH linked to a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93d704754396c46e98d108868ba91df2
https://hal.science/hal-00748999

Inhibitory effects of a series of 7-substituted-indazoles toward nitric oxide synthases: Particular potency of 1H-indazole-7-carbonitrile

Autor: Jean Luc Boucher, Betty Cottyn, Dominique Vichard, Booma Ramassamy, Daniel Mansuy, Francine Acher, Michel Lepoivre, Luke J. Alvey, Yves Frapart, Dennis J. Stuehr

Publikováno v: Bioorganic and Medicinal Chemistry
Bioorganic and Medicinal Chemistry, Elsevier, 2008, 16 (11), pp.5962-5973. ⟨10.1016/j.bmc.2008.04.056⟩

A series of new 7-monosubstituted and 3,7-disubstituted indazoles have been prepared and evaluated as inhibitors of nitric oxide synthases (NOS). 1H-Indazole-7-carbonitrile (6) was found equipotent to 7-nitro-1H-indazole (1) and demonstrated preferen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c2676f7ba8b8e91fd745d845341f2bb
https://hal.inrae.fr/hal-02921674

Regulation of NADPH-dependent Nitric Oxide and reactive oxygen species signalling in endothelial and melanoma cells by a photoactive NADPH analogue

Autor: Stéphane Rocchi, Huan-Huan Wang, Anny Slama-Schwok, Jean-Luc Boucher, Eric Deprez, Booma Ramassamy, Patrick Tauc, Miguel Romero-Perez, Florian Rouaud, Irina Lobysheva, Etienne Henry, Damien Giacchero

Publikováno v: ResearcherID
Oncotarget
Oncotarget, Impact journals, 2014, 5 (21), pp.10650-10664. ⟨10.18632/oncotarget.2525⟩
Oncotarget, Impact journals, 2014, 5 (21), pp.10650-64. ⟨10.18632/oncotarget.2525⟩

International audience; Nitric Oxide (NO) and Reactive oxygen species (ROS) are endogenous regulators of angiogenesis-related events as endothelial cell proliferation and survival, but NO/ROS defect or unbalance contribute to cancers. We recently des

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc2f3066e848bf3e9c675426c73ae1ad
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000348036900034&KeyUID=WOS:000348036900034