Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Boojala Vijay B. Reddy"'
Autor:
Zachary Charlop-Powers, Jeremy G Owen, Boojala Vijay B Reddy, Melinda A Ternei, Denise O Guimarães, Ulysses A de Frias, Monica T Pupo, Prudy Seepe, Zhiyang Feng, Sean F Brady
Publikováno v:
eLife, Vol 4 (2015)
Recent bacterial (meta)genome sequencing efforts suggest the existence of an enormous untapped reservoir of natural-product-encoding biosynthetic gene clusters in the environment. Here we use the pyro-sequencing of PCR amplicons derived from both non
Externí odkaz:
https://doaj.org/article/229ca8aa72364012976b9718217905d4
Autor:
Louis J. Cohen, Sean F. Brady, Joel S. Freundlich, David S. Perlin, Henry Zebroski, Boojala Vijay B. Reddy, Wooyoung Cho, John Chu, Melinda A. Ternei, Xavier Vila-Farrés, Daigo Inoyama, Christophe Lemetre
Publikováno v:
Journal of the American Chemical Society. 139:1404-1407
Bacterial culture broth extracts have been the starting point for the development of numerous therapeutics. However, only a small fraction of bacterial biosynthetic diversity is accessible using this strategy. Here, we apply a discovery approach that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fbcc76a9ee302a2b1a4baf1a8513399
https://doi.org/10.1021/jacs.6b11861
https://doi.org/10.1021/jacs.6b11861
Autor:
Daniel Montiel, Sean F. Brady, Melinda A. Ternei, Alexandra G. Smith, Zachary Charlop-Powers, Jeremy G. Owen, Paula Y. Calle, Boojala Vijay B. Reddy
Publikováno v:
Proceedings of the National Academy of Sciences. 112:4221-4226
In molecular evolutionary analyses, short DNA sequences are used to infer phylogenetic relationships among species. Here we apply this principle to the study of bacterial biosynthesis, enabling the targeted isolation of previously unidentified natura
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d662a7544d4e46ee1af17832276093bf
https://doi.org/10.1073/pnas.1501124112
https://doi.org/10.1073/pnas.1501124112
Autor:
Henry Zebroski, Joel S. Freundlich, Xavier Vila-Farrés, Boojala Vijay B. Reddy, David S. Perlin, Shruthi Satish, Mark Jaskowski, Daigo Inoyama, Louis J. Cohen, Emma A. Gordon, Zachary Charlop-Powers, Ricardo Gallardo-Macias, Melinda A. Ternei, John Chu, Steven Park, Sean F. Brady
Publikováno v:
Nature chemical biology
Here we present a natural product discovery approach, whereby structures are bioinformatically predicted from primary sequence and produced by chemical synthesis (synthetic-bioinformatic natural products, syn-BNPs), circumventing the need for bacteri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d68a6056a5768d19b384cb075149fea
https://doi.org/10.1038/nchembio.2207
https://doi.org/10.1038/nchembio.2207
Autor:
Zachary Charlop-Powers, Sean F. Brady, Boojala Vijay B. Reddy, Jeremy G. Owen, Melinda A. Ternei
Publikováno v:
Proceedings of the National Academy of Sciences. 111:3757-3762
In this study, we compare biosynthetic gene richness and diversity of 96 soil microbiomes from diverse environments found throughout the southwestern and northeastern regions of the United States. The 454-pyroseqencing of nonribosomal peptide adenyla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::175be7a80e3b91d88adda5cb67063338
https://doi.org/10.1073/pnas.1318021111
https://doi.org/10.1073/pnas.1318021111
Autor:
Sean F. Brady, Melinda A. Ternei, Boojala Vijay B. Reddy, Jeffrey Kim, Jeremy G. Owen, Paula Y. Calle, Zachary Charlop-Powers
Publikováno v:
Proceedings of the National Academy of Sciences. 110:11797-11802
Complex microbial ecosystems contain large reservoirs of unexplored biosynthetic diversity. Here we provide an experimental framework and data analysis tool to facilitate the targeted discovery of natural-product biosynthetic gene clusters from the e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b357f48f3ee49ece23f29d4332fc1e86
https://doi.org/10.1073/pnas.1222159110
https://doi.org/10.1073/pnas.1222159110
Autor:
Hernán A. Navarro, Boojala Vijay B. Reddy, Wayne W. Harding, Pooja Makkar, Sandeep Chaudhary, Stevan Pecic
Publikováno v:
Bioorganic & Medicinal Chemistry. 18:5562-5575
Analogs of nantenine were docked into a modeled structure of the human 5-HT(2A) receptor using ICM Pro, GLIDE, and GOLD docking methods. The resultant docking scores were used to correlate with observed in vitro apparent affinity (K(e)) data. The GOL
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ef26ed01e37d4b0aece724271b6f955
https://doi.org/10.1016/j.bmc.2010.06.043
https://doi.org/10.1016/j.bmc.2010.06.043
Autor:
Munehito Yoshida, Sreedhara Sangadala, F Louisa Titus, Yunshan Liu, Motohiro Okada, Scott D. Boden, Boojala Vijay B. Reddy
Publikováno v:
Cell Biochemistry and Function. 27:526-534
The requirement of large amounts of the recombinant human bone morphogenetic protein-2 (BMP-2) produces a huge translational barrier for its routine clinical use due to high cost. This leads to an urgent need to develop alternative methods to lower c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c15faebbf64169ea2baae370eddbc32
https://doi.org/10.1002/cbf.1615
https://doi.org/10.1002/cbf.1615
Publikováno v:
Journal of Molecular Graphics and Modelling. 27:803-812
The Smads are a group of related intracellular proteins critical for transmitting the signals to the nucleus from the transforming growth factor-beta (TGF-beta) superfamily of proteins at the cell surface. The prototypic members of the Smad family, M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ef255b4d869982b538c95046fb2c84f
https://doi.org/10.1016/j.jmgm.2008.12.003
https://doi.org/10.1016/j.jmgm.2008.12.003
Publikováno v:
Journal of Biosciences. 32:929-936
Protein secondary structure predictions and amino acid long range contact map predictions from primary sequence of proteins have been explored to aid in modelling protein tertiary structures. In order to evaluate the usefulness of secondary structure
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9032ef0d21d2423e9087dbfa61b215e7
https://doi.org/10.1007/s12038-007-0093-1
https://doi.org/10.1007/s12038-007-0093-1