3D Cell-Based Assays for Drug Screens: Challenges in Imaging, Image Analysis, and High-Content Analysis

Autor: Booij, Tijmen H., Price, Leo S. ^*, Danen, Erik H.J. ^**

Publikováno v: In SLAS Discovery July 2019 24(6):615-627

High-Throughput Phenotypic Screening of Kinase Inhibitors to Identify Drug Targets for Polycystic Kidney Disease

Autor: Booij, Tijmen H., Bange, Hester, Leonhard, Wouter N., Yan, Kuan, Fokkelman, Michiel, Kunnen, Steven J., Dauwerse, Johannes G., Qin, Yu, van de Water, Bob, van Westen, Gerard J.P., Peters, Dorien J.M., Price, Leo S. ^*

Publikováno v: In SLAS Discovery September 2017 22(8):974-984

In vitro 3D phenotypic drug screen identifies celastrol as an effective in vivo inhibitor of polycystic kidney disease

Autor: Booij, Tijmen H., Leonhard, Wouter N., Bange, Hester, Yan, Kuan, Fokkelman, Michiel, Plugge, Anna J., Veraar, Kimberley A. M., Dauwerse, Johannes J., van Westen, Gerard J.P., Van de Water, Bob, Price, Leo S., Peters, Dorien J.M.

Publikováno v: Journal of molecular cell biology, 12 (8)

Polycystic kidney disease (PKD) is a prevalent genetic disorder, characterized by the formation of kidney cysts that progressively lead to kidney failure. The currently available drug tolvaptan is not well tolerated by all patients and there remains

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9180f5371287a17ada3ce015138ee957
https://hdl.handle.net/20.500.11850/454499

In vitro 3D phenotypic drug screen identifies celastrol as an effective in vivo inhibitor of polycystic kidney disease.

Autor: Booij, Tijmen H, Leonhard, Wouter N, Bange, Hester, Yan, Kuan, Fokkelman, Michiel, Plugge, Anna J, Veraar, Kimberley A M, Dauwerse, Johannes G, Westen, Gerard J P van, van de Water, Bob, Price, Leo S, Peters, Dorien J M

Publikováno v: Journal of Molecular Cell Biology; Aug2020, Vol. 12 Issue 8, p644-653, 10p

Epac-rap signaling reduces oxidative stress in the tubular epithelium

Autor: Stokman, Geurt, Qin, Yu, Booij, Tijmen H., Ramaiahgari, Sreenivasa, Lacombe, Marie, Dolman, M. Emmy M., Van Dorenmalen, Kim M.A., Teske, Gwendoline J.D., Florquin, Sandrine, Schwede, Frank, Van De Water, Bob, Kok, Robbert J., Price, Leo S., Sub Drug delivery, Pharmaceutics

Publikováno v: Journal of the American Society of Nephrology, 25(7), 1474-1485. American Society of Nephrology
Journal of the American Society of Nephrology, 25(7), 1474. American Society of Nephrology

Activation of Rap1 by exchange protein activated by cAMP (Epac) promotes cell adhesion and actin cytoskeletal polarization. Pharmacologic activation of Epac-Rap signaling by the Epac-selective cAMP analog 8-pCPT-2'-O-Me-cAMP during ischemia-reperfusi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0a901a020a9399280e30b8580461b69
https://hdl.handle.net/1874/309986