Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Boobalan Pachaiyappan"'
Autor:
Adam L. Borne, Tao Huang, Rebecca L. McCloud, Ku-Lung Hsu, Boobalan Pachaiyappan, Timothy N. J. Bullock
Publikováno v:
Current Topics in Microbiology and Immunology ISBN: 9783030111427
As a major sentinel of adaptive immunity, T cells seek and destroy diseased cells using antigen recognition to achieve molecular specificity. Strategies to block checkpoint inhibition of T cell activity and thus reawaken the patient's antitumor immun
Autor:
Ruslan Sanishvili, Richard B. Silverman, John F. Kellie, Boobalan Pachaiyappan, Emma H. Doud, Hyunbeom Lee, Rui Wu, Dali Liu, Phillip D. Compton, Hoang V. Le, Neil L. Kelleher
Publikováno v:
ACS Chemical Biology. 10:2087-2098
When γ-aminobutyric acid (GABA), the major inhibitory neurotransmitter in the mammalian central nervous system, falls below a threshold level, seizures occur. One approach to raise GABA concentrations is to inhibit GABA aminotransferase (GABA-AT), a
Autor:
Steven L. Holshouser, Boobalan Pachaiyappan, Youxuan Li, Robert A. Casero, Shiv K. Sharma, Patrick M. Woster, Yi Huang, Shannon L. Nowotarski, Craig J. Kutz
Publikováno v:
Bioorganic & Medicinal Chemistry. 26:3728-3729
Methylation at specific histone lysine residues is a critical post-translational modification that alters chromatin architecture, and dysregulated lysine methylation/demethylation is associated with the silencing of tumor suppressor genes. The enzyme
Autor:
Michael G. Schmidt, Bo Wang, Jordon D. Gruber, Boobalan Pachaiyappan, Patrick M. Woster, Yong-Mei Zhang
Publikováno v:
Journal of medicinal chemistry. 59(7)
Antibiotic resistance is a growing threat to human health exacerbated by a lack of new antibiotics. We now describe a series of substituted diamines that produce rapid bactericidal activity against both Gram-positive and Gram-negative bacteria, inclu
Autor:
Stuart T. Hazeldine, Boobalan Pachaiyappan, Patrick M. Woster, Shannon L. Nowotarski, Robert A. Casero, Nora Steinbergs, Allison S. Hanson
Publikováno v:
Journal of Medicinal Chemistry. 55:7378-7391
The recently discovered enzyme lysine-specific demethylase 1 (LSD1) plays an important role in the epigenetic control of gene expression, and aberrant gene silencing secondary to LSD1 dysregulation is thought to contribute to the development of cance
Autor:
Raghavendra G. Mirmira, Aarthi V. Maganti, Megan L. Sampley, Sabire Özcan, Patrick M. Woster, Sarah A. Tersey, Boobalan Pachaiyappan, Chad S. Hunter, Bernhard Maier, Amber L. Mosley, Roland Stein
Background: Pdx1 interacts with the methyltransferase Set7/9 to transactivate β cell genes. Results: Methylation of Pdx1 residue Lys-131 by Set7/9 augments Pdx1 activity. Conclusion: The ability of Pdx1 to regulate genes in β cells is partially dep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94fbaa724dfb1060efa052eee7218d5f
https://europepmc.org/articles/PMC4392279/
https://europepmc.org/articles/PMC4392279/
Autor:
Boobalan Pachaiyappan
Publikováno v:
Biochemistry & Analytical Biochemistry.
Therapeutic validation of peptidyl-tRNA hydrolase (Pth) inhibition to discover novel antibacterial drug scaffolds is encumbered by lack of medicinal chemistry efforts and a simple easy-to-implement assay procedure for the analysis of Pth activity. In
Autor:
Youxuan Li, Shannon L. Nowotarski, Patrick M. Woster, Robert A. Casero, Yi Huang, Boobalan Pachaiyappan, Craig J. Kutz, Steven L. Holshouser, Shiv K. Sharma
Publikováno v:
Bioorganicmedicinal chemistry. 23(7)
Methylation at specific histone lysine residues is a critical post-translational modification that alters chromatin architecture, and dysregulated lysine methylation/demethylation is associated with the silencing of tumor suppressor genes. The enzyme
Autor:
Lyn-Marie Birkholtz, Bianca K. Verlinden, Kiplin R. Guy, Riëtte van Biljon, Ethan Besaans, Marna de Beer, Patrick M. Woster, Jandeli Niemand, Janette Reader, Timothy J. Egan, Warren A. Andayi, Boobalan Pachaiyappan
Publikováno v:
Bioorganicmedicinal chemistry. 23(16)
A new series of potent potent aryl/alkylated (bis)urea- and (bis)thiourea polyamine analogues were synthesized and evaluated in vitro for their antiplasmodial activity. Altering the carbon backbone and terminal substituents increased the potency of a
Publikováno v:
Bioorganicmedicinal chemistry letters. 24(1)
The field of epigenetics has expanded rapidly to reveal multiple new targets for drug discovery. The functional elements of the epigenomic machinery can be categorized as writers, erasers and readers, and together these elements control cellular gene