A small PAM optimises target recognition in the CRISPR-Cas immune system

Autor: Bonomo, Melia E.

CRISPR-Cas is an adaptive immune mechanism that has been harnessed for a variety of genetic engineering applications: the Cas9 protein recognises a 2-5nt DNA motif, known as the PAM, and a programmable crRNA binds a target DNA sequence that is then c

Externí odkaz: http://arxiv.org/abs/2101.01303

Music to My Ears: Neural modularity and flexibility differ in response to real-world music stimuli

Autor: Bonomo, Melia E., Brandt, Anthony K., Frazier, J. Todd, Karmonik, Christof

Music listening involves many simultaneous neural operations, including auditory processing, working memory, temporal sequencing, pitch tracking, anticipation, reward, and emotion, and thus, a full investigation of music cognition would benefit from

Externí odkaz: http://arxiv.org/abs/2010.04269

Predicting influenza H3N2 vaccine efficacy from evolution of the dominant epitope

Autor: Bonomo, Melia E., Deem, Michael W.

We predict vaccine efficacy with a measure of antigenic distance between influenza A(H3N2) and candidate vaccine viruses based on amino acid substitutions in the dominant epitopes. In 2016-2017, our model predicts 19% efficacy compared to 20% observe

Externí odkaz: http://arxiv.org/abs/1804.04751

How the other half lives: CRISPR-Cas's influence on bacteriophages

Autor: Bonomo, Melia E., Deem, Michael W.

Publikováno v: Evolutionary Biology : Self, Non-Self Evolution, Species and Complex Traits, Evolution, Methods and Concepts, ISBN 978-3-319-61569-1, edited by Pierre Pontarotti, Springer Nature, September 2017, pp. 63-85

CRISPR-Cas is a genetic adaptive immune system unique to prokaryotic cells used to combat phage and plasmid threats. The host cell adapts by incorporating DNA sequences from invading phages or plasmids into its CRISPR locus as spacers. These spacers

Externí odkaz: http://arxiv.org/abs/1711.09113

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