Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Bonnie W Lau"'
Publikováno v:
PLoS ONE, Vol 19, Iss 1, p e0292375 (2024)
Fanconi anemia (FA)-mutated acute myeloid leukemia (AML) is a secondary AML with very poor prognosis and limited therapeutic options due to increased sensitivity to DNA-damaging agents. PD-1 immune checkpoint inhibitors upregulate T-cell killing of c
Externí odkaz:
https://doaj.org/article/c59f827a07a3479e815fb6090a3fc451
Autor:
Alyssa L. Kennedy, Kasiani C. Myers, James Bowman, Christopher J. Gibson, Nicholas D. Camarda, Elissa Furutani, Gwen M. Muscato, Robert H. Klein, Kaitlyn Ballotti, Shanshan Liu, Chad E. Harris, Ashley Galvin, Maggie Malsch, David Dale, John M. Gansner, Taizo A. Nakano, Alison Bertuch, Adrianna Vlachos, Jeffrey M. Lipton, Paul Castillo, James Connelly, Jane Churpek, John R. Edwards, Nobuko Hijiya, Richard H. Ho, Inga Hofmann, James N. Huang, Siobán Keel, Adam Lamble, Bonnie W. Lau, Maxim Norkin, Elliot Stieglitz, Wendy Stock, Kelly Walkovich, Steffen Boettcher, Christian Brendel, Mark D. Fleming, Stella M. Davies, Edie A. Weller, Christopher Bahl, Scott L. Carter, Akiko Shimamura, R. Coleman Lindsley
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Understanding the molecular basis of leukaemia predisposition is essential for intervention. The authors here investigate germline genetic leukaemia predisposition by studying Shwachman-Diamond syndrome and report compensatory inactivating mutations
Externí odkaz:
https://doaj.org/article/911d91b30d4548af8f9e72d025592f4b
Autor:
Winfred C. Wang, Ashley Galvin, Maggie Malsch, Rabi Hanna, Kasiani C. Myers, Edie Weller, Leann Mount, Bonnie W Lau, Kelan Queenan, Robert B. Lorsbach, Taizo A. Nakano, Adrianna Vlachos, Shanshan Liu, Mark D. Fleming, Sarah K. Steltz, Stella M. Davies, Jordan Henry Larson, Sara Loveless, Akiko Shimamura, Elissa Furutani, Sioban Keel, Amy E. Geddis, John M. Gansner, Alison A. Bertuch, Jeffrey M. Lipton
Publikováno v:
Blood Advances
Key Points Severe bone marrow failure was primarily observed in early childhood in children with biallelic SBDS mutations.Absolute neutrophil counts were positively associated with age (P < .0001) in patients with biallelic SBDS mutations.
Visua
Visua
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e781b5291a00cc8249c1831deb3cc9a
https://doi.org/10.1182/bloodadvances.2021005539
https://doi.org/10.1182/bloodadvances.2021005539
Autor:
Ding-Wen Chen, Tingting Huang, Yuyang Huang, Stephanie N Hurwitz, Julie Schrey, Jian-Meng Fan, Martin Carroll, Peter Kurre, Bonnie W Lau
Publikováno v:
Blood. 140:5776-5777
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::777b5c1eb6cbd0e84e854ebaf3e8ea54
https://doi.org/10.1182/blood-2022-158615
https://doi.org/10.1182/blood-2022-158615
Autor:
Katie Bergstrom, Yigal Dror, Kathleen Overholt, Melissa J. Rose, Paul Castillo, Beth A Carella, Kristin A. Shimano, Bonnie W Lau, James N. Huang, Larisa Broglie, Evan Shereck, Steven W. Allen, Timothy S. Olson, Jessica Boklan, Anupama Narla, Catherine E. McGuinn, Taizo A. Nakano, Adrianna Vlachos, Marcin W. Wlodarski, Amy E. Geddis, Nicholas J. Gloude, Jill L. O. de Jong, Anjali Sharathkumar, Jennifer A. Rothman, Akiko Shimamura, Alison A. Bertuch
Publikováno v:
American journal of hematologyREFERENCES. 96(11)
The North American Pediatric Aplastic Anemia Consortium (NAPAAC) is a group of pediatric hematologist-oncologists, hematopathologists, and bone marrow transplant physicians from 46 institutions in North America with interest and expertise in aplastic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11dc98ef0351af66663ab855bc7c1e77
https://pubmed.ncbi.nlm.nih.gov/34342889
https://pubmed.ncbi.nlm.nih.gov/34342889
Autor:
John M. Gansner, James Bowman, Jane E. Churpek, Gwen M. Muscato, Richard H. Ho, Adam J. Lamble, Mark D. Fleming, Robert H. Klein, Alison A. Bertuch, Shanshan Liu, Wendy Stock, Jeffrey M. Lipton, Christian Brendel, Ashley Galvin, James A. Connelly, Nicholas D. Camarda, Christopher J. Gibson, Christopher D. Bahl, Chad E. Harris, Kasiani C. Myers, Sioban Keel, R. Coleman Lindsley, Kelly Walkovich, Maggie Malsch, Bonnie W Lau, Alyssa L. Kennedy, Kaitlyn Ballotti, John R. Edwards, David C. Dale, Akiko Shimamura, Stella M. Davies, Elliot Stieglitz, Scott L. Carter, Paul Castillo, Steffen Boettcher, Taizo A. Nakano, Adrianna Vlachos, Maxim Norkin, Elissa Furutani, Edie Weller, Nobuko Hijiya, Inga Hofmann, James N. Huang
Publikováno v:
Nature communications, vol 12, iss 1
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Nature Communications
To understand the mechanisms that mediate germline genetic leukemia predisposition, we studied the inherited ribosomopathy Shwachman-Diamond syndrome (SDS), a bone marrow failure disorder with high risk of myeloid malignancies at an early age. To def
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac6bc53e8cfbeaac3fa14099826d19da
https://doi.org/10.1038/s41467-021-21588-4
https://doi.org/10.1038/s41467-021-21588-4
Autor:
Maxim Norkin, Sixi Liu, R. C. Lindsley, Alison A. Bertuch, Christopher D. Bahl, Ashley Galvin, Jane E. Churpek, Nicholas D. Camarda, Elissa Furutani, Wendy Stock, Jeffrey M. Lipton, Bonnie W Lau, Christian Brendel, James A. Connelly, Scott L. Carter, Steffen Boettcher, David C. Dale, Sioban Keel, Alyssa L. Kennedy, Kasiani C. Myers, Inga Hofmann, John R. Edwards, Akiko Shimamura, James Bowman, Chad E. Harris, James N. Huang, Richard H. Ho, Rüdiger Klein, Mark D. Fleming, Maggie Malsch, Taizo A. Nakano, Adrianna Vlachos, John M. Gansner, Christopher J. Gibson, Stella M. Davies, Elliot Stieglitz, Paul Castillo, Adam J. Lamble, Edie Weller, G. M. Muscato, Nobuko Hijiya, Kaitlyn Ballotti, Kelly Walkovich
Shwachman-Diamond syndrome (SDS) is an inherited bone marrow failure syndrome with predisposition to developing leukemia. We found that multiple independent somatic hematopoietic clones arise early in life, most commonly harboring heterozygous mutati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2a72a878ae541d1387584ab459615d13
https://doi.org/10.1101/2020.06.04.134692
https://doi.org/10.1101/2020.06.04.134692
Autor:
Kristen Campbell, Marcin W. Wlodarski, Kathryn E. Dickerson, Taizo A. Nakano, Yigal Dror, Akiko Shimamura, Michaela Cada, Inga Hofmann, Rabbi Hanna, Timothy S. Olson, Hilda Ding, Tarek M. Elghetany, Ghadir S. Sasa, Jessica A. Pollard, Steven William Allen, Bonnie W Lau
Publikováno v:
Pediatric bloodcancerREFERENCES. 67(10)
Background Myelodysplastic syndromes (MDS) represent a group of clonal hematopoietic stem cell disorders that commonly progress to acute myeloid leukemia (AML). The diagnostics, prognostics, and treatment of adult MDS are established but do not direc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b3a0950bf49b204cfcff3b122b5d740
https://pubmed.ncbi.nlm.nih.gov/32779892
https://pubmed.ncbi.nlm.nih.gov/32779892
Autor:
Lukasz P. Gondek, Peter D. Aplan, Luigi Marchionni, Amy E. DeZern, Francisco Pereira Lobo, Douglas B. Smith, Federico De Marchi, Bonnie W. Lau, Kyounghee Huh, Mark J. Levis, Qiuju Wang, William Matsui, Rafael Madero-Marroquin, Yiting Lim
Publikováno v:
Oncogene. 38:687-698
Myelodysplastic syndromes (MDSs) are stem cell disorders with risk of transformation to acute myeloid leukemia (AML). Gene expression profiling reveals transcriptional expression of GLI1, of Hedgehog (Hh) signaling, in poor-risk MDS/AML. Using a muri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d35f0a010a8b43e668aeb80b5f07484b
https://doi.org/10.1038/s41388-018-0431-9
https://doi.org/10.1038/s41388-018-0431-9
Autor:
Maria Vittoria Dubbini, Carla Filì, Renato Fanin, Federico De Marchi, Nicholas Rabassi, Maria Elena Zannier, Davide Lazzarotto, Anna Candoni, Eleonora Toffoletti, Bonnie W. Lau
Publikováno v:
Leukemia Research. 63:22-27
We analyzed the outcome of allogeneic stem cell transplantation (allo-SCT) in acute myeloid leukemia (AML) patients according to molecular Minimal Residual Disease (MRD) status prior to allo-SCT. MRD was assessed by the quantitative expression of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3aeb5f782c5da5566ffae35ab49573aa
https://doi.org/10.1016/j.leukres.2017.10.010
https://doi.org/10.1016/j.leukres.2017.10.010