Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Bonnie V Dougherty"'
Autor:
Bonnie V Dougherty, Connor J Moore, Kristopher D Rawls, Matthew L Jenior, Bryan Chun, Sarbajeet Nagdas, Jeffrey J Saucerman, Glynis L Kolling, Anders Wallqvist, Jason A Papin
Publikováno v:
PLoS Computational Biology, Vol 20, Iss 2, p e1011919 (2024)
Improvements in the diagnosis and treatment of cancer have revealed long-term side effects of chemotherapeutics, particularly cardiotoxicity. Here, we present paired transcriptomics and metabolomics data characterizing in vitro cardiotoxicity to thre
Externí odkaz:
https://doaj.org/article/f1a37666eac248b987c7dc28c5799574
Publikováno v:
PLoS Computational Biology, Vol 16, Iss 4, p e1007099 (2020)
The metabolic responses of bacteria to dynamic extracellular conditions drives not only the behavior of single species, but also entire communities of microbes. Over the last decade, genome-scale metabolic network reconstructions have assisted in our
Externí odkaz:
https://doaj.org/article/832bfc8fafa54838ab04dc02b0df07aa
Autor:
Benjamin D, Leibowitz, Bonnie V, Dougherty, Joshua S K, Bell, Joshuah, Kapilivsky, Jackson, Michuda, Andrew J, Sedgewick, Wesley A, Munson, Tushar A, Chandra, Jonathan R, Dry, Nike, Beaubier, Catherine, Igartua, Timothy, Taxter
Publikováno v:
BMC Cancer. 22
BackgroundWith the introduction of DNA-damaging therapies into standard of care cancer treatment, there is a growing need for predictive diagnostics assessing homologous recombination deficiency (HRD) status across tumor types. Following the strong c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7acde809710900dfa72e6fdb6a95a446
https://doi.org/10.1186/s12885-022-09669-z
https://doi.org/10.1186/s12885-022-09669-z
Autor:
Jason A. Papin, Bonnie V. Dougherty
Publikováno v:
Current Opinion in Toxicology. :74-79
Translation of biological knowledge from animal models to humans is an important step in the development of therapeutics, but there remain limitations for effective translation. Systems biology offers approaches to understand the limitations for tran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f1a4b47b090b5c9ba6ae95db971d296f
https://doi.org/10.1016/j.cotox.2020.06.002
https://doi.org/10.1016/j.cotox.2020.06.002
Autor:
Benjamin Leibowitz, Bonnie V Dougherty, Joshua SK Bell, Joshuah Kapilivsky, Jackson Michuda, Andrew Sedgwick, Wesley Munson, Tushar Chandra, Jonathan R Dry, Nike Beaubier, Catherine Igartua, Timothy Taxter
BackgroundWith the introduction of DNA-damaging therapies into standard of care cancer treatment, there is a growing need for predictive diagnostics assessing homologous recombination deficiency (HRD) status across tumor types. Following the strong c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c713e85db2fb93206b659ff5c74ee93c
https://doi.org/10.1101/2021.12.20.21267985
https://doi.org/10.1101/2021.12.20.21267985
Autor:
Jeffrey J. Saucerman, Kristopher D. Rawls, Anders Wallqvist, Jason A. Papin, Matthew L. Jenior, Sarbajeet Nagdas, Bonnie V. Dougherty, Glynis L. Kolling, Bryan Chun
Improvements in the diagnosis and treatment of cancer has revealed the long-term side effects of chemotherapeutics, particularly cardiotoxicity. Here, we present paired transcriptomics and metabolomics data characterizing in vitro cardiotoxicity to t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e308cd313275108c93d024e88bed406e
https://doi.org/10.1101/2021.10.31.466544
https://doi.org/10.1101/2021.10.31.466544
Autor:
William B. Mattes, Michael A. Schmidt, Julian C Schmidt, Richard D. Beger, Dean P. Jones, Bonnie V. Dougherty
Publikováno v:
Int J Toxicol
Metabolomics is unique among omics technologies in being applicable to metabolism and toxicity studies broadly across organisms (e.g., humans, other mammals, model organisms, and even bacteria) and across biological materials (e.g., blood, urine, sal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e947c418009022e4ef4b7c4a0093430
https://pubmed.ncbi.nlm.nih.gov/34514887
https://pubmed.ncbi.nlm.nih.gov/34514887
Autor:
Kalyan C. Vinnakota, Glynis L. Kolling, Bonnie V. Dougherty, Kristopher D. Rawls, Jason A. Papin, Anders Wallqvist
Publikováno v:
Cell Reports, Vol 34, Iss 10, Pp 108836-(2021)
Summary In diseased states, the heart can shift to use different carbon substrates, measured through changes in uptake of metabolites by imaging methods or blood metabolomics. However, it is not known whether these measured changes are a result of tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::046e52bb7ce0398942ead1090eda6942
http://www.sciencedirect.com/science/article/pii/S2211124721001509
http://www.sciencedirect.com/science/article/pii/S2211124721001509
Autor:
Matthew MacKay, Joshua Drews, Bonnie V. Dougherty, Duane Hassane, Chris Mason, Gaurav Khullar, Calvin Chao, Joel Dudley, Kimberly L. Blackwell, Nike T. Beaubier, Justin Guinney
Publikováno v:
Cancer Research. 82:62-62
Background: Actionable genomic alterations can be identified through either a biopsy of solid tissue or the detection of circulating tumor DNA from plasma. Little is known about the concordance rates of pathogenic variants between cell free DNA (cfDN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::33b813983614f72efacd2f5ed66e0577
https://doi.org/10.1158/1538-7445.am2022-62
https://doi.org/10.1158/1538-7445.am2022-62
Autor:
Kalyan C. Vinnakota, Anders Wallqvist, Glynis L. Kolling, Bonnie V. Dougherty, Jason A. Papin, Kristopher D. Rawls
SummaryThe heart is a metabolic omnivore, known to consume many different carbon substrates in order to maintain function. In diseased states, the heart’s metabolism can shift between different carbon substrates; however, there is some disagreement
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5cd85b0c6c6e589bb0187321c6fa1397
https://doi.org/10.1101/2020.07.20.212274
https://doi.org/10.1101/2020.07.20.212274