Zobrazeno 1 - 10 of 17 pro vyhledávání: '"Bonnie L Bullock"'
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Akademický článek
Cancer cell-intrinsic expression of MHC II in lung cancer cell lines is actively restricted by MEK/ERK signaling and epigenetic mechanisms
Autor: Alexander J Neuwelt, Abigail K Kimball, Amber M Johnson, Benjamin W Arnold, Bonnie L Bullock, Rachael E Kaspar, Emily K Kleczko, Jeff W Kwak, Meng-Han Wu, Lynn E Heasley, Robert C Doebele, Howard Y Li, Raphael A Nemenoff, Eric T Clambey
Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 8, Iss 1 (2020)
Background Programmed death 1/programmed death ligand 1 (PD-1/PD-L1) targeted immunotherapy affords clinical benefit in ~20% of unselected patients with lung cancer. The factor(s) that determine whether a tumor responds or fails to respond to immunot
Externí odkaz: https://doaj.org/article/392478c81db649bab2de6e5e9eb696a8
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2
Data from Activation of PPARγ in Myeloid Cells Promotes Progression of Epithelial Lung Tumors through TGFβ1
Autor: Raphael A. Nemenoff, Mary C. Weiser-Evans, Emily K. Kleczko, Jeff W. Kwak, Joanna M. Poczobutt, Bonnie L. Bullock, Teresa T. Nguyen, Dwight Hanson, Howard Y. Li, Amber M. Johnson, Trisha R. Sippel
Lung cancer is a heterogeneous disease in which patient-specific treatments are desirable and the development of targeted therapies has been effective. Although mutations in KRAS are frequent in lung adenocarcinoma, there are currently no targeted ag
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::93d4a05dbf3de9fd90b2006695996f89
https://doi.org/10.1158/1541-7786.c.6541266
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7
Activation of PPARγ in Myeloid Cells Promotes Progression of Epithelial Lung Tumors through TGFβ1
Autor: Joanna M. Poczobutt, Emily K Kleczko, Mary C. Weiser-Evans, Amber M. Johnson, Trisha R. Sippel, Jeff W. Kwak, Dwight Hanson, Raphael A. Nemenoff, Bonnie L. Bullock, Teresa Nguyen, Howard Li
Publikováno v: Mol Cancer Res
Lung cancer is a heterogeneous disease in which patient-specific treatments are desirable and the development of targeted therapies has been effective. Although mutations in KRAS are frequent in lung adenocarcinoma, there are currently no targeted ag
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::928ab165671ef61c67d66735affd3a63
https://doi.org/10.1158/1541-7786.mcr-19-0236
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8
CD8+ T cells modulate autosomal dominant polycystic kidney disease progression
Autor: Mary C.M. Weiser-Evans, Emily K. Kleczko, Bonnie L. Bullock, Peter C. Harris, Katharina Hopp, Christopher Altmann, Seth B. Furgeson, Raphael A. Nemenoff, Logan C. Tyler, Michel Chonchol, Eric T. Clambey, Berenice Gitomer, Makoto Miyazaki, Kenneth H. Marsh
Publikováno v: Kidney International. 94:1127-1140
Autosomal dominant polycystic kidney disease (ADPKD) is the most prevalent inherited nephropathy. To date, therapies alleviating the disease have largely focused on targeting abnormalities in renal epithelial cell signaling. ADPKD has many hallmarks
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1a515819e4cfd3eeb246e0d3ebc31e58
https://doi.org/10.1016/j.kint.2018.06.025
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9
Cancer cell-intrinsic expression of MHC II in lung cancer cell lines is actively restricted by MEK/ERK signaling and epigenetic mechanisms
Autor: Abigail K. Kimball, Bonnie L. Bullock, Emily K Kleczko, Lynn E. Heasley, Benjamin W Arnold, Robert C. Doebele, Rachael E. Kaspar, Meng-Han Wu, Alexander J. Neuwelt, Eric T. Clambey, Howard Li, Jeff W. Kwak, Amber M. Johnson, Raphael A. Nemenoff
Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 8, Iss 1 (2020)
Journal for Immunotherapy of Cancer
BackgroundProgrammed death 1/programmed death ligand 1 (PD-1/PD-L1) targeted immunotherapy affords clinical benefit in ~20% of unselected patients with lung cancer. The factor(s) that determine whether a tumor responds or fails to respond to immunoth
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86d4c850f343fb56defa1d48905815b4
https://jitc.bmj.com/content/8/1/e000441.full
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10
Cancer Cell Intrinsic Expression of MHCII Regulates the Immune Microenvironment and Response to Anti-PD-1 Therapy in Lung Adenocarcinoma
Autor: Erin L. Schenk, Howard Li, Rachael E. Kaspar, Bonnie L. Bullock, Katharina Hopp, Jeff W. Kwak, Lynn E. Heasley, Raphael A. Nemenoff, Mary C.M. Weiser-Evans, Amber M. Johnson, Eric T. Clambey, Joanna M. Poczobutt, Alexander J. Neuwelt
MHC class II (MHCII) expression is usually restricted to antigen presenting cells, but can be expressed by cancer cells. We examined the effect of cancer cell-intrinsic MHC class II (csMHCII) expression in lung adenocarcinoma on T cell recruitment to
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82d173e2cd898da3952dcf8d5691071b
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