Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Bonnie J. Bolkan"'
Autor:
Jill S. Wentzell, Bonnie J. Bolkan, Katia Carmine-Simmen, Tracy L. Swanson, Derek T. Musashe, Doris Kretzschmar
Publikováno v:
Neurobiology of Disease, Vol 46, Iss 1, Pp 78-87 (2012)
The processing of Amyloid Precursor Proteins (APPs) results in several fragments, including soluble N-terminal ectodomains (sAPPs) and C-terminal intracellular domains (AICD). sAPPs have been ascribed neurotrophic or neuroprotective functions in cell
Externí odkaz:
https://doaj.org/article/33045ddec3b049e5b1df7a6bf5d889a5
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e89847 (2014)
loechrig (loe) mutant flies are characterized by progressive neuronal degeneration, behavioral deficits, and early death. The mutation is due to a P-element insertion in the gene for the γ-subunit of the trimeric AMP-activated protein kinase (AMPK)
Externí odkaz:
https://doaj.org/article/114194acf99e472ba58a6cedb60d452e
Autor:
Doris Kretzschmar, Bonnie J. Bolkan
Publikováno v:
Developmental Neurobiology. 74:1210-1225
Accumulations of Tau, a microtubule-associated protein (MAP), into neurofibrillary tangles is a hallmark of Alzheimer's disease and other tauopathies. However, the mechanisms leading to this pathology are still unclear: the aggregates themselves coul
Publikováno v:
The Journal of Neuroscience. 32:16181-16192
β-secretase (or BACE1) is the key enzyme in the production of β-amyloid (Aβ), which accumulates in the senile plaques characteristic for Alzheimer's disease. Consequently, the lack of BACE1 prevents β-processing of the amyloid precursor protein a
Publikováno v:
Genetics. 177:2233-2241
Matings between D. melanogaster females and males of sibling species in the D. melanogaster complex yield hybrid males that die prior to pupal differentiation. We have reexamined a previous report suggesting that the developmental defects in these le
Autor:
Maria Grazia Giansanti, Violaine Mottier, Silvia Bonaccorsi, Byron C. Williams, Bonnie J. Bolkan, Michael L. Goldberg, Maurizio Gatti
Publikováno v:
Development (Camb.) 134 (2007): 2183–2193. doi:10.1242/dev.02848
info:cnr-pdr/source/autori:Bonaccorsi S, Mottier V, Giansanti MG, Bolkan BJ, Williams B, Goldberg ML, Gatti M./titolo:The Drosophila Lkb1 kinase is required for spindle formation and asymmetric neuroblast division./doi:10.1242%2Fdev.02848/rivista:Development (Camb.)/anno:2007/pagina_da:2183/pagina_a:2193/intervallo_pagine:2183–2193/volume:134
info:cnr-pdr/source/autori:Bonaccorsi S, Mottier V, Giansanti MG, Bolkan BJ, Williams B, Goldberg ML, Gatti M./titolo:The Drosophila Lkb1 kinase is required for spindle formation and asymmetric neuroblast division./doi:10.1242%2Fdev.02848/rivista:Development (Camb.)/anno:2007/pagina_da:2183/pagina_a:2193/intervallo_pagine:2183–2193/volume:134
We have isolated lethal mutations in the Drosophila lkb1 gene(dlkb1), the homolog of C. elegans par-4 and human LKB1 (STK11), which is mutated in Peutz-Jeghers syndrome. We show that these mutations disrupt spindle formation, resulting in frequent po
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e89847 (2014)
PLoS ONE
PLoS ONE
loechrig (loe) mutant flies are characterized by progressive neuronal degeneration, behavioral deficits, and early death. The mutation is due to a P-element insertion in the gene for the γ-subunit of the trimeric AMP-activated protein kinase (AMPK)
Autor:
Katia Carmine-Simmen, Tracy L. Swanson, Jill S. Wentzell, Bonnie J. Bolkan, Derek T. Musashe, Doris Kretzschmar
Publikováno v:
Neurobiology of Disease, Vol 46, Iss 1, Pp 78-87 (2012)
The processing of Amyloid Precursor Proteins (APPs) results in several fragments, including soluble N-terminal ectodomains (sAPPs) and C-terminal intracellular domains (AICD). sAPPs have been ascribed neurotrophic or neuroprotective functions in cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9675a859699fcd3a7f189024bb082d10
https://europepmc.org/articles/PMC4073673/
https://europepmc.org/articles/PMC4073673/