Zobrazeno 1 - 10
of 79
pro vyhledávání: '"Bonnie J Howell"'
Autor:
Guoxin Wu, Samuel H. Keller, Luca Sardo, Brian Magliaro, Paul Zuck, Carl J. Balibar, Claire Williams, Liuliu Pan, Mark Gregory, Kathy Ton, Jill Maxwell, Carol Cheney, Tom Rush, Bonnie J. Howell
Publikováno v:
Biomarker Research, Vol 12, Iss 1, Pp 1-13 (2024)
Abstract Background Latency remains a major obstacle to finding a cure for HIV despite the availability of antiretroviral therapy. Due to virus dormancy, limited biomarkers are available to identify latent HIV-infected cells. Profiling of individual
Externí odkaz:
https://doaj.org/article/01fa0f698e854c8984b8df83b5423713
Autor:
Stephen W. Wietgrefe, Jodi Anderson, Lijie Duan, Peter J. Southern, Paul Zuck, Guoxin Wu, Bonnie J. Howell, Cavan Reilly, Eugène Kroon, Suthat Chottanapund, Supranee Buranapraditkun, Carlo Sacdalan, Nicha Tulmethakaan, Donn J. Colby, Nitiya Chomchey, Peeriya Prueksakaew, Suteeraporn Pinyakorn, Rapee Trichavaroj, Julie L. Mitchell, Lydie Trautmann, Denise Hsu, Sandhya Vasan, Sopark Manasnayakorn, Mark de Souza, Sodsai Tovanabutra, Alexandra Schuetz, Merlin L. Robb, Nittaya Phanuphak, Jintanat Ananworanich, Timothy W. Schacker, Ashley T. Haase, on behalf of the RV254/SEARCH 010 Study Team
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 22 (2023)
Productively infected cells are generally thought to arise from HIV infection of activated CD4+ T cells, and these infected activated cells are thought to be a recurring source of latently infected cells when a portion of the population transitions t
Externí odkaz:
https://doaj.org/article/905df81d5c464ce19a8c8991675960d9
Autor:
Ryan P. Staupe, Kenneth E. Lodge, Nithya Thambi, David Toole, Alex M. Tamburino, Dan Chang, Bonnie J. Howell, Daria J. Hazuda, Kalpit A. Vora, Nicole L. Sullivan
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-14 (2022)
CD102 is an enriched biomarker for long-lived plasma cells in non-human primates (NHPs) and is conserved across NHPs, humans, and mice.
Externí odkaz:
https://doaj.org/article/8c82de59a3bc4667afdd35ab15839d7e
Autor:
Stephen H. Kasper, Stephanie Otten, Brian Squadroni, Cionna Orr‐Terry, Yi Kuang, Lily Mussallem, Lan Ge, Lin Yan, Srinivasaraghavan Kannan, Chandra S. Verma, Christopher J. Brown, Charles W. Johannes, David P. Lane, Arun Chandramohan, Anthony W. Partridge, Lee R. Roberts, Hubert Josien, Alex G. Therien, Erik C. Hett, Bonnie J. Howell, Andrea Peier, Xi Ai, Jason Cassaday
Publikováno v:
Bioengineering & Translational Medicine, Vol 8, Iss 5, Pp n/a-n/a (2023)
Abstract Cyclic peptides are poised to target historically difficult to drug intracellular protein–protein interactions, however, their general cell impermeability poses a challenge for characterizing function. Recent advances in microfluidics have
Externí odkaz:
https://doaj.org/article/4ede5586001347c2a4d447e4b2a014ec
Autor:
Karine Dubé, Harsh Agarwal, William B. Carter, Lynda Dee, Jeff Taylor, Christopher Roebuck, Beth Peterson, Hursch Patel, Samuel Ndukwe, Kenneth M. Lynn, Linden Lalley-Chareczko, Emily Hiserodt, Sukyung Kim, Daniel Rosenbloom, Brad R. Evans, Melanie Anderson, Daria J. Hazuda, Kevin Bateman, Bonnie J. Howell, Livio Azzoni, Karam Mounzer, Pablo Tebas, Luis J. Montaner
Publikováno v:
HIV Research & Clinical Practice, Vol 23, Iss 1, Pp 76-90 (2022)
Background: HIV cure-directed clinical trials using analytical treatment interruptions (ATIs) require participants to adhere to frequent monitoring visits for viral load tests. Novel viral load monitoring strategies are needed to decrease participant
Externí odkaz:
https://doaj.org/article/05fbd233a40d4f83afda13ea5699851d
Autor:
Karine Dubé, John Kanazawa, Christopher Roebuck, Steven Johnson, William B. Carter, Lynda Dee, Beth Peterson, Kenneth M. Lynn, Linden Lalley-Chareczko, Emily Hiserodt, Sukyung Kim, Daniel Rosenbloom, Brad R. Evans, Melanie Anderson, Daria J. Hazuda, Lisa Shipley, Kevin Bateman, Bonnie J. Howell, Karam Mounzer, Pablo Tebas, Luis J. Montaner
Publikováno v:
HIV Research & Clinical Practice, Vol 23, Iss 1, Pp 120-135 (2022)
Background People with HIV (PWH) and community members have advocated for the development of a home-based viral load test device that could make analytical treatment interruptions (ATIs) less burdensome. Objective We assessed community acceptability
Externí odkaz:
https://doaj.org/article/d5f0d32e8dbc42dd958bb6aeb88bedaa
Autor:
Justin Harper, Susan P. Ribeiro, Chi Ngai Chan, Malika Aid, Claire Deleage, Luca Micci, Maria Pino, Barbara Cervasi, Gopalan Raghunathan, Eric Rimmer, Gulesi Ayanoglu, Guoxin Wu, Neeta Shenvi, Richard J.O. Barnard, Gregory Q. Del Prete, Kathleen Busman-Sahay, Guido Silvestri, Deanna A. Kulpa, Steven E. Bosinger, Kirk A. Easley, Bonnie J. Howell, Dan Gorman, Daria J. Hazuda, Jacob D. Estes, Rafick-Pierre Sekaly, Mirko Paiardini
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 8 (2022)
Interleukin-10 (IL-10) is an immunosuppressive cytokine that signals through STAT3 to regulate T follicular helper (Tfh) cell differentiation and germinal center formation. In SIV-infected macaques, levels of IL-10 in plasma and lymph nodes (LNs) wer
Externí odkaz:
https://doaj.org/article/3c551d2d1a814a3d84819bbd3a685652
Autor:
Shane D. Falcinelli, Jackson J. Peterson, Anne-Marie W. Turner, David Irlbeck, Jenna Read, Samuel L.M. Raines, Katherine S. James, Cameron Sutton, Anthony Sanchez, Ann Emery, Gavin Sampey, Robert Ferris, Brigitte Allard, Simon Ghofrani, Jennifer L. Kirchherr, Caroline Baker, JoAnn D. Kuruc, Cynthia L. Gay, Lindsey I. James, Guoxin Wu, Paul Zuck, Inmaculada Rioja, Rebecca C. Furze, Rab K. Prinjha, Bonnie J. Howell, Ronald Swanstrom, Edward P. Browne, Brian D. Strahl, Richard M. Dunham, Nancie M. Archin, David M. Margolis
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 8 (2022)
Latency reversal strategies for HIV cure using inhibitor of apoptosis protein (IAP) antagonists (IAPi) induce unprecedented levels of latent reservoir expression without immunotoxicity during suppressive antiretroviral therapy (ART). However, full ta
Externí odkaz:
https://doaj.org/article/4373bee6f4264a5fa37799577488e1df
Publikováno v:
Frontiers in Microbiology, Vol 12 (2021)
Greater than 90% of HIV-1 proviruses are thought to be defective and incapable of viral replication. While replication competent proviruses are of primary concern with respect to disease progression or transmission, studies have shown that even defec
Externí odkaz:
https://doaj.org/article/6569eabb69f64325bf06a22952fda386
Autor:
Sarah M. Rothman, Keith Q. Tanis, Pallavi Gandhi, Vladislav Malkov, Jacob Marcus, Michelle Pearson, Richard Stevens, Jason Gilliland, Christopher Ware, Veeravan Mahadomrongkul, Elaine O’Loughlin, Gonzalo Zeballos, Roger Smith, Bonnie J. Howell, Joel Klappenbach, Matthew Kennedy, Christian Mirescu
Publikováno v:
Journal of Neuroinflammation, Vol 15, Iss 1, Pp 1-15 (2018)
Abstract Background Alzheimer’s disease (AD) is a chronic neurodegenerative disease with pathological hallmarks including the formation of extracellular aggregates of amyloid-beta (Aβ) known as plaques and intracellular tau tangles. Coincident wit
Externí odkaz:
https://doaj.org/article/8e009419f5ab45f69aae66002d9935b3