SARS-CoV-2 tropism, entry, replication, and propagation: Considerations for drug discovery and development.

Autor: Nicholas Murgolo, Alex G Therien, Bonnie Howell, Daniel Klein, Kenneth Koeplinger, Linda A Lieberman, Gregory C Adam, Jessica Flynn, Philip McKenna, Gokul Swaminathan, Daria J Hazuda, David B Olsen

Publikováno v: PLoS Pathogens, Vol 17, Iss 2, p e1009225 (2021)

Since the initial report of the novel Coronavirus Disease 2019 (COVID-19) emanating from Wuhan, China, Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has spread globally. While the effects of SARS-CoV-2 infection are not completely unde

Externí odkaz: https://doaj.org/article/6909c68dee10406c8b165a62d0e69a18

Mathematical Modeling: A Tool for Optimization of Lipid Nanoparticle-Mediated Delivery of siRNA

Autor: Radu Mihaila, Dipali Ruhela, Edward Keough, Elena Cherkaev, Silvia Chang, Beverly Galinski, René Bartz, Duncan Brown, Bonnie Howell, James J. Cunningham

Publikováno v: Molecular Therapy: Nucleic Acids, Vol 7, Iss C, Pp 246-255 (2017)

Lipid nanoparticles (LNPs) have been used to successfully deliver small interfering RNAs (siRNAs) to target cells in both preclinical and clinical studies and currently are the leading systems for in vivo delivery. Here, we propose the use of an ordi

Externí odkaz: https://doaj.org/article/1bd07484f2df466c8fe8c61876a16515

30 Changes in expression of small non-coding RNA during HIV infection and latency in a CD4+ T cell model of HIV latency

Autor: SaiVikram Vemula, Bonnie Howell

Publikováno v: Journal of Virus Eradication, Vol 3, Iss , Pp 17-18 (2017)

Externí odkaz: https://doaj.org/article/e94b037b49ef4448bc523f54d4423625

Antiretroviral therapy alone versus antiretroviral therapy with a kick and kill approach, on measures of the HIV reservoir in participants with recent HIV infection (the RIVER trial): a phase 2, randomised trial

Autor: Sarah Fidler, Wolfgang Stöhr, Matt Pace, Lucy Dorrell, Andrew Lever, Sarah Pett, Sabine Kinloch-de Loes, Julie Fox, Amanda Clarke, Mark Nelson, John Thornhill, Maryam Khan, Axel Fun, Mikaila Bandara, Damian Kelly, Jakub Kopycinski, Tomáš Hanke, Hongbing Yang, Rachel Bennett, Margaret Johnson, Bonnie Howell, Richard Barnard, Guoxin Wu, Steve Kaye, Mark Wills, Abdel Babiker, John Frater, Eric Sandström, Janet Darbyshire, Frank Post, Christopher Conlon, Jane Anderson, Mala Maini, Timothy Peto, Peter Sasieni, Veronica Miller, Ian Weller, Matthew Pace, Natalia Olejniczak, Helen Brown, Nicola Robinson, Alison Crook, Steven Kaye, Myra McClure, Otto Erlwein, Andrew Lovell, Michelle Gabrielle, Aminata Sy, Adam Gregory, Fleur Hudson, Charlotte Russell, Gemma Wood, Hanna Box, Cherry Kingsley, Katie Topping, Simon Collins, Alex Markham, Mary Rauchenberger, Yinka Sowunmi, Shaadi Shidfar, Dominic Hague, Maddalena Cerrone, Nadia Castrillo Martinez, Tristan Barber, Alexandra Schoolmeesters, Christine Weaver, Orla Thunder, Jane Rowlands, Christopher Higgs, Serge Fedele, Margherita Bracchi, Lervina Thomas, Peter Bourke, Nneka Nwokolo, Gaynor Lawrenson, Marzia Fiorino, Hinal Lukha, Alice Nightingale, Nnenna Ngwu, Patrick Byrne, Zoe Cuthbertson, Martin Jones, Tina Fernandez, Martin Fisher, Rebecca Gleig, Vittorio Trevitt, Colin Fitzpatrick, Tanya Adams, Fiounnuala Finnerty, Heather Lewis, Kristin Kuldanek, Julianne Lwanga, Hiromi Uzu, Ming Lee, Simon Merle, Patrick O'Rourke, Isabel Jendrulek, Taras ZarkoFlynn, Mark Taylor, Juan Manuel Tiraboschi, Tammy Murray

Background: Antiretroviral therapy (ART) cannot cure HIV infection because of a persistent reservoir of latently infected cells. Approaches that force HIV transcription from these cells, making them susceptible to killing—termed kick and kill regim

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e0a9acad04ffeedd118ca1e0283aec7
https://doi.org/10.1016/s0140-6736(19)32990-3

Spindle Checkpoint Protein Dynamics at Kinetochores in Living Cells

Autor: Scott R. Stewart, Bonnie Howell, Edward D. Salmon, Ben Moree, Guowei Fang, Emily M Farrar

Publikováno v: Current Biology. 14:953-964

BACKGROUND: To test current models for how unattached and untense kinetochores prevent Cdc20 activation of the anaphase-promoting complex/cyclosome (APC/C) throughout the spindle and the cytoplasm, we used GFP fusions and live-cell imaging to quantif

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1331c152261ffca3c916d9238d4794b5
https://doi.org/10.1016/j.cub.2004.05.053