Výsledky vyhledávání - "Bonnie Chang"

Immunostimulatory oligonucleotides block allergic airway inflammation by inhibiting Th2 cell activation and IgE-mediated cytokine induction

Autor: Jennifer O. Lizcano, Mabel Chu, Robert L. Coffman, Marsha Wills-Karp, Edith M. Hessel, Sariah A. Kell, Nancy S. Herman, Bonnie Chang

Publikováno v: The Journal of Experimental Medicine

A single treatment with a CpG-containing immunostimulatory DNA sequence (ISS) given before allergen challenge can inhibit T helper type 2 cell (Th2)–mediated airway responses in animal models of allergic asthma; however, the mechanism of this inhib

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8dde314086e64831996457d98fa3f570
https://doi.org/10.1084/jem.20050631

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Nucleic acids of mammalian origin can act as endogenous ligands for Toll-like receptors and may promote systemic lupus erythematosus

Autor: Shizuo Akira, Satoshi Uematsu, Josh Gregorio, Bonnie Chang, Jean H. Chan, Franck J. Barrat, Robert L. Coffman, Omar Duramad, Thea Meeker

Publikováno v: The Journal of Experimental Medicine

Raised serum levels of interferon (IFN)-alpha have been observed in systemic lupus erythematosus (SLE) patients, and these levels are correlated with both disease activity and severity. The origin of this IFN-alpha is still unclear, but increasing ev

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a718c043800c21e9164f6a33974d2d52
https://doi.org/10.1084/jem.20050914

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Biomarker discovery and transcriptomic responses in Daphnia magna exposed to munitions constituents

Autor: Natàlia Garcia-Reyero, B. Lynn Escalon, Julia R. Varshavsky, Bonnie Chang, Xin Guan, Alex Loguinov, Helen C. Poynton, Chris D. Vulpe, Edward J. Perkins, Alan J. Kennedy

Publikováno v: Environmental sciencetechnology. 43(11)

Ecotoxicogenomic approaches are emerging as alternative methods in environmental monitoring because they allow insight into pollutant modes of action and help assess the causal agents and potential toxicity beyond the traditional end points of death,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::922d6d31c088d31882b5697b8386b12f
https://pubmed.ncbi.nlm.nih.gov/19569350

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Daphnia magna ecotoxicogenomics provides mechanistic insights into metal toxicity

Autor: Helen C. Poynton, Giorgio Cavigiolio, Elizabeth C. Theil, Owen Hughes, Sarah Chan, Alexandre Loguinov, Darren J. Bauer, Kelly Komachi, Julia R. Varshavsky, Edward J. Perkins, Chris D. Vulpe, Patricia S. Holman, Bonnie Chang

Publikováno v: Environmental sciencetechnology. 41(3)

Toxicogenomics has provided innovative approaches to chemical screening, risk assessment, and predictive toxicology. If applied to ecotoxicology, genomics tools could greatly enhance the ability to understand the modes of toxicity in environmentally

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::218ff6a43afdc983c6a34902319a9141
https://pubmed.ncbi.nlm.nih.gov/17328222

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Inhibitors of TLR-9 act on multiple cell subsets in mouse and man in vitro and prevent death in vivo from systemic inflammation

Autor: Karen L. Fearon, Franck J. Barrat, Omar Duramad, Jean H. Chan, Josh Gregorio, Bonnie Chang, Robert L. Coffman

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 174(9)

In parallel with the discovery of the immunostimulatory activities of CpG-containing oligodeoxynucleotides, several groups have reported specific DNA sequences that could inhibit activation by CpG-containing oligodeoxynucleotides in mouse models. We

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::654c678e2a8d8465ce9c91b5ddf5a3b9
https://pubmed.ncbi.nlm.nih.gov/15843514

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