Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Bonnie Andrais"'
Publikováno v:
International Journal of Molecular Sciences, Vol 16, Iss 5, Pp 11609-11628 (2015)
Phosphorylation of H2AX on Ser139 (γH2AX) after exposure to ionizing radiation produces nuclear foci that are detectable by immunofluorescence microscopy. These so-called γH2AX foci have been adopted as quantitative markers for DNA double-strand br
Externí odkaz:
https://doaj.org/article/90e027eeb1b1408a8e04952f8e6f5a0b
Publikováno v:
International Journal of Molecular Sciences, Vol 14, Iss 11, Pp 22409-22435 (2013)
Ionizing radiation triggers diverse responses in human cells encompassing apoptosis, necrosis, stress-induced premature senescence (SIPS), autophagy, and endopolyploidy (e.g., multinucleation). Most of these responses result in loss of colony-forming
Externí odkaz:
https://doaj.org/article/68ac2dfddc3e45d3b9b99ff294e021b0
Publikováno v:
Cancers, Vol 10, Iss 8, p 255 (2018)
A subset of cells within solid tumors become highly enlarged and enter a state of dormancy (sustained proliferation arrest) in response to anticancer treatment. Although dormant cancer cells might be scored as “dead” in conventional preclinical a
Externí odkaz:
https://doaj.org/article/9e5bfc1145d94c76a77d2e1cc9615fe0
Publikováno v:
Cancers, Vol 10, Iss 4, p 118 (2018)
Tumors and tumor-derived cell lines contain polyploid giant cells with significantly elevated genomic content, often with multiple nuclei. The frequency of giant cells can increase markedly following anticancer treatment. Although giant cells enter a
Externí odkaz:
https://doaj.org/article/599c40397b844c088a6a880c5a6e01ff
Publikováno v:
International Journal of Molecular Sciences, Vol 18, Iss 8, p 1679 (2017)
Cell-based assays in multiwell plates are widely used for radiosensitivity and chemosensitivity assessment with different mammalian cell types. Despite their relative ease of performance, such assays lack specificity as they do not distinguish betwee
Externí odkaz:
https://doaj.org/article/74477ce28e7443bd92a27c70e8fd77a6
Publikováno v:
International Journal of Molecular Sciences, Vol 18, Iss 7, p 1460 (2017)
In most p53 wild-type human cell types, radiosensitivity evaluated by the colony formation assay predominantly reflects stress-induced premature senescence (SIPS) and not cell death (Int. J. Mol. Sci. 2017, 18, 928). SIPS is a growth-arrested state i
Externí odkaz:
https://doaj.org/article/adf3103a7ac54aca865bc0239526d3cf
Publikováno v:
International Journal of Molecular Sciences, Vol 18, Iss 2, p 360 (2017)
Loss of wild-type p53 function is widely accepted to be permissive for the development of multinucleated giant cells. However, whether therapy-induced multinucleation is associated with cancer cell death or survival remains controversial. Herein, we
Externí odkaz:
https://doaj.org/article/1e59862a3ce44b01b92ac2b42b8d3d5d
Publikováno v:
International Journal of Molecular Sciences, Vol 17, Iss 5, p 708 (2016)
It is widely stated that wild-type p53 either mediates the activation of cell cycle checkpoints to facilitate DNA repair and promote cell survival, or orchestrates apoptotic cell death following exposure to cancer therapeutic agents. This reigning pa
Externí odkaz:
https://doaj.org/article/8397c428b47c438f875196091183aa3b
Publikováno v:
Biochemistry Research International, Vol 2012 (2012)
The p16INK4A (hereafter p16) tumor suppressor is encoded by the INK4A/ARF locus which is among the most commonly dysregulated sequences in human cancer. By inhibiting cyclin-dependent kinases, p16 activates the G1-S checkpoint, and this response is o
Externí odkaz:
https://doaj.org/article/4d14cf1ab3914573b735dabfe50f679d
Publikováno v:
Cancers, Vol 10, Iss 4, p 118 (2018)
Cancers
Cancers
Tumors and tumor-derived cell lines contain polyploid giant cells with significantly elevated genomic content, often with multiple nuclei. The frequency of giant cells can increase markedly following anticancer treatment. Although giant cells enter a