Výsledky vyhledávání - "Bonnie, Yates"

Akademický článek

Cryopreserved anti-CD22 and bispecific anti-CD19/22 CAR T cells are as effective as freshly infused cells

Autor: Alexandra Dreyzin, Sandhya R. Panch, Haneen Shalabi, Bonnie Yates, Steven L. Highfill, Ping Jin, David Stroncek, Nirali N. Shah

Publikováno v: Molecular Therapy: Methods & Clinical Development, Vol 28, Iss , Pp 51-61 (2023)

Cryopreservation of chimeric antigen receptor (CAR) T cells facilitates shipment, timing of infusions, and storage of subsequent doses. However, reports on the impact of cryopreservation on CAR T cell efficacy have been mixed. We retrospectively comp

Externí odkaz: https://doaj.org/article/b7798ef47ea843b29b8ef539a38ccb2c

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Akademický článek

CD22 CAR T-cell associated hematologic toxicities, endothelial activation and relationship to neurotoxicity

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 11, Iss 6 (2023)

Background Hematologic toxicities, including coagulopathy, endothelial activation, and cytopenias, with CD19-targeted chimeric antigen receptor (CAR) T-cell therapies correlate with cytokine release syndrome (CRS) and neurotoxicity severity, but litt

Externí odkaz: https://doaj.org/article/67779dd2b8c74a5ebbccf3603b290777

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Akademický článek

Case Report: Fatal Complications of BK Virus-Hemorrhagic Cystitis and Severe Cytokine Release Syndrome Following BK Virus-Specific T-Cells

Autor: Elizabeth M. Holland, Corina Gonzalez, Elliot Levy, Vladimir A. Valera, Heather Chalfin, Jacquelyn Klicka-Skeels, Bonnie Yates, David E. Kleiner, Colleen Hadigan, Hema Dave, Haneen Shalabi, Dennis D. Hickstein, Helen C. Su, Michael Grimley, Alexandra F. Freeman, Nirali N. Shah

Publikováno v: Frontiers in Immunology, Vol 12 (2021)

BK virus (BKV)-hemorrhagic cystitis (HC) is a well-known and rarely fatal complication of hematopoietic stem cell transplantation (HSCT). Treatment for BKV-HC is limited, but virus-specific T-cells (VST) represent a promising therapeutic option feasi

Externí odkaz: https://doaj.org/article/6353932677624ec1a63e996fb77da356

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The impact of race, ethnicity, and obesity on CAR T-cell therapy outcomes

Autor: Aiman J. Faruqi, John A. Ligon, Paul Borgman, Seth M. Steinberg, Toni Foley, Lauren Little, Crystal L. Mackall, Daniel W. Lee, Terry J. Fry, Haneen Shalabi, Jennifer Brudno, Bonnie Yates, Lekha Mikkilineni, James Kochenderfer, Nirali N. Shah

Publikováno v: Blood Advances. 6:6040-6050

Cancer outcomes with chemotherapy are inferior in patients of minority racial/ethnic groups and those with obesity. Chimeric antigen receptor (CAR) T-cell therapy has transformed outcomes for relapsed/refractory hematologic malignancies, but whether

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2cd02fab6b0f8d4e007d9cdbb06967c
https://doi.org/10.1182/bloodadvances.2022007676

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Akademický článek

Impact of cytokine release syndrome on cardiac function following CD19 CAR-T cell therapy in children and young adults with hematological malignancies

Autor: Crystal Mackall, Haneen Shalabi, Vandana Sachdev, Amita Kulshreshtha, Julia W Cohen, Bonnie Yates, Doug R Rosing, Stanislav Sidenko, Cindy Delbrook, Brandon Wiley, Daniel W Lee, Nirali N Shah

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 8, Iss 2 (2020)

Background Chimeric antigen receptor (CAR) T-cell-associated cytokine release syndrome (CRS) may present with tachycardia, hemodynamic instability and reduced cardiac function. Pediatric CAR studies examining cardiac toxicity are limited.Methods We r

Externí odkaz: https://doaj.org/article/bd2b97bd87de45fa847e89470db39128

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Akademický článek

Diagnostic approach to the evaluation of myeloid malignancies following CAR T-cell therapy in B-cell acute lymphoblastic leukemia

Autor: Aimee C Talleur, Brandon M Triplett, Haneen Shalabi, Bonnie Yates, Nirali N Shah, George Mo, Hao-Wei Wang, Shilpa A Shahani, Michael G Douvas, Katherine R Calvo, Jack F Shern, Sridhar Chaganti, Katharine Patrick, Young Song, Terry J Fry, Xiaolin Wu, Javed Khan, Rebecca A Gardner

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 8, Iss 2 (2020)

Immunotherapeutic strategies targeting B-cell acute lymphoblastic leukemia (B-ALL) effectively induce remission; however, disease recurrence remains a challenge. Due to the potential for antigen loss, antigen diminution, lineage switch or development

Externí odkaz: https://doaj.org/article/9165dfbe9bda40b7991cff5cb81c8857

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