Mesenchymal stromal cells expressing a dominant-negative high mobility group A1 transgene exhibit improved function during sepsis

Autor: Sailaja Ghanta, Bonna Ith, Min-Young Kwon, Ana P. Castano, James A. Lederer, Julie Ng, Xiaoli Liu, Junwen Han, Souheil El-Chemaly, Mark A. Perrella, Su Wol Chung

Publikováno v: Journal of Leukocyte Biology

High mobility group (HMG)A proteins are nonhistone chromatin proteins that bind to the minor groove of DNA, interact with transcriptional machinery, and facilitate DNA‐directed nuclear processes. HMGA1 has been shown to regulate genes involved with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe05b998cc150ceb61e324c5acd3ba57
https://doi.org/10.1002/jlb.4a0720-424r

CD148 Deficiency in Fibroblasts Promotes the Development of Pulmonary Fibrosis

Autor: Souheil El-Chemaly, Kevin Xiong, Xiaoli Liu, James R. Whiteford, Ivan O. Rosas, Sergio Poli, Sarah G. Chu, Stefan W. Ryter, Yuan Yuan Shi, Matthew J. Robertson, Bonna Ith, Giulia De Rossi, Freddy Romero, Xiaoliang Liang, Mark A. Perrella, Lindsay J. Celada, Konstantin Tsoyi, Anthony J. Esposito

Publikováno v: Am J Respir Crit Care Med
American Journal of Respiratory and Critical Care Medicine

Rationale: CD148/PTRJ (receptor-like protein tyrosine phosphatase η) exerts antifibrotic effects in experimental pulmonary fibrosis via interactions with its ligand syndecan-2; however, the role of CD148 in human pulmonary fibrosis remains incomplet

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::879c983a151290dcff09ccb340d0a4ee
https://europepmc.org/articles/PMC8513593/

Carbon Monoxide Improves Efficacy of Mesenchymal Stromal Cells During Sepsis by Production of Specialized Proresolving Lipid Mediators*

Autor: Charles N. Serhan, Xiaoli Liu, Laura E. Fredenburgh, Rebecca M. Baron, Bonna Ith, Sean Hall, Jesmond Dalli, Anna Coronata, Mark A. Perrella, Konstantin Tsoyi, Augustine M.K. Choi, Sailaja Ghanta, Romain A. Colas

Publikováno v: Tsoyi, Konstantin; Hall, Sean; Dalli, Jesmond; Colas, Romain A; Ghanta, Sailaja; Ith, Bonna; Coronata, Anna; Fredenburgh, Laura E; Baron, Rebecca M; Choi, Augustine M K; Serhan, Charles N; Liu, Xiaoli; Perrella, Mark A (2016). Carbon Monoxide Improves Efficacy of Mesenchymal Stromal Cells During Sepsis by Production of Specialized Proresolving Lipid Mediators. Critical care medicine, 44(12), e1236-e1245. Lippincott Williams & Wilkins 10.1097/CCM.0000000000001999
Critical Care Medicine

Supplemental Digital Content is available in the text.
Objectives: Mesenchymal stromal cells are being investigated as a cell-based therapy for a number of disease processes, with promising results in animal models of systemic inflammation and s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b64ffe66b65e6a9f4fb3bbca56246372
https://doi.org/10.1097/ccm.0000000000001999

Mesenchymal Stromal Cells Improve Survival During Sepsis in the Absence of Heme Oxygenase-1: The Importance of Neutrophils

Autor: Xiaoli Liu, James A. Lederer, Bonna Ith, Sean Hall, Mark A. Perrella, Robert F. Padera, Zhihong Wang, Konstantin Tsoyi

Publikováno v: Stem Cells. 31:397-407

The use of mesenchymal stromal cells (MSCs) for treatment of bacterial infections, including systemic processes like sepsis, is an evolving field of investigation. This study was designed to investigate the potential use of MSCs, harvested from compa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21c8e0983cbc48e68e4f92f0782c78a7
https://doi.org/10.1002/stem.1270

Increased Neointima Formation in Cysteine-Rich Protein 2–Deficient Mice in Response to Vascular Injury

Autor: Alan Tseng, Shaw-Fang Yet, Matthew D. Layne, Bonna Ith, Daniel I. Simon, Jiao Wei, Zhiping Chen, Xiaoli Liu, Terri E. Gorman

Publikováno v: Circulation Research. 97:1323-1331

In response to arterial injury, medial vascular smooth muscle cells (VSMCs) proliferate and migrate into the intima, contributing to the development of occlusive vascular disease. The LIM protein cysteine-rich protein (CRP) 2 associates with the acti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff3e49cf24b56334734c1682e4eaa5b3
https://doi.org/10.1161/01.res.0000194331.76925.5c