Výsledky vyhledávání - "Bonita L. Blake"

Directed Evolution of a Novel Adeno-associated Virus (AAV) Vector That Crosses the Seizure-compromised Blood–Brain Barrier (BBB)

Autor: Steven J, Gray, Bonita L, Blake, Hugh E, Criswell, Sarah C, Nicolson, R Jude, Samulski, Thomas J, McCown, Wuping, Li

Publikováno v: Molecular Therapy. 18:570-578

DNA shuffling and directed evolution were employed to develop a novel adeno-associated virus (AAV) vector capable of crossing the seizure-compromised blood–brain barrier (BBB) and transducing cells in the brain. Capsid DNA from AAV serotypes 1–6,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69ee72d786761ad4f52c7ae018699657
https://doi.org/10.1038/mt.2009.292

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Changes in apical dendritic structure correlate with sustained ERK1/2 phosphorylation in medial prefrontal cortex of a rat model of dopamine D1receptor agonist sensitization

Autor: George R. Breese, Sophia T. Papadeas, Christopher Halloran, Thomas J. McCown, Bonita L. Blake

Publikováno v: The Journal of Comparative Neurology. 511:271-285

Rats lesioned with 6-hydroxydopamine (6-OHDA) as neonates exhibit behavioral and neurochemical abnormalities in adulthood that mimic Lesch-Nyhan disease, schizophrenia and other developmental disorders of frontostriatal circuit dysfunction. In these

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8b6a07b7b6d94fb2490f54eb04ea9e4
https://doi.org/10.1002/cne.21835

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Nifedipine Suppresses Self-Injurious Behaviors in Animals

Autor: Kiyoshi Egami, Hyder A. Jinnah, Amber M. Muehlmann, Bonita L. Blake, George R. Breese, Darragh P. Devine

Publikováno v: Developmental Neuroscience. 29:241-250

Self-injurious behavior is a common problem in many developmental disorders. The neurobiology of this behavior is not well understood, but the differing behavioral manifestations and associations with different disorders suggest that the underlying b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51b44bf781fc69eef537d22d1d218721
https://doi.org/10.1159/000096414

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Functional Selectivity of Dopamine Receptor Agonists. II. Actions of Dihydrexidine in D2LReceptor-Transfected MN9D Cells and Pituitary Lactotrophs

Autor: Karen L. O'Malley, Jason D. Kilts, Gerry S. Oxford, Cindy P. Lawler, David E. Nichols, Bonita L. Blake, Elaine G. Arrington, Hilary S. Connery, Mechelle M. Lewis, Richard D. Todd, Richard B. Mailman

Publikováno v: Journal of Pharmacology and Experimental Therapeutics. 301:1179-1189

D(2)-like dopamine receptors mediate functional changes via activation of inhibitory G proteins, including those that affect adenylate cyclase activity, and potassium and calcium channels. Although it is assumed that the binding of a drug to a single

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b339d015b287c237d8d01c0f164aedd9
https://doi.org/10.1124/jpet.301.3.1179

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Gβ Association and Effector Interaction Selectivities of the Divergent Gγ Subunit Gγ13

Autor: Qiubo Lei, T. Kendall Harden, Jennie R. Hillmann, Bonita L. Blake, Michele R. Wing, David P. Siderovski, Cynthia I. Behe, Rebecca A. Morris, Janice Y. Zhou, Richard J. Miller, Douglas A. Bayliss

Publikováno v: Journal of Biological Chemistry. 276:49267-49274

Gγ13 is a divergent member of the Gγ subunit family considered to be a component of the gustducin G-protein heterotrimer involved in bitter and sweet taste reception in taste bud cells. Gγ13 contains a C-terminal asparagine-proline-tryptophan (NPW

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d8e0330e022b45ecb21380214b8bb3ab
https://doi.org/10.1074/jbc.m106565200

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Opposing actions of hippocampus TNFα receptors on limbic seizure susceptibility

Autor: Bonita L. Blake, Marc S. Weinberg, Thomas J. McCown

Publikováno v: Experimental neurology. 247

Resected epileptic tissues exhibit elements of chronic neuroinflammation that include elevated TNFα and increased TNFα receptor activation, but the seizure related consequences of chronic TNFα expression remain unknown. Twenty four hours after acu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58e198347cda619927d7fa1ef56d066f
https://pubmed.ncbi.nlm.nih.gov/23707217

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The influence of epileptic neuropathology and prior peripheral immunity on CNS transduction by rAAV2 and rAAV5

Autor: Bonita L. Blake, Marc S. Weinberg, Thomas J. McCown, Richard Jude Samulski

Adeno-associated virus (AAV) provides a promising platform for clinical treatment of neurological disorders owing to its established efficacy and lack of apparent pathogenicity. To use viral vectors in treating neurological disease, however, transduc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::271d034e7f95f5c8ac249cc1f0777e23

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The role of dopamine receptors in the neurobehavioral syndrome provoked by activation of L-type calcium channels in rodents

Autor: Xueliang Fan, Suhail Kasim, George R. Breese, Ellen J. Hess, Elena H. Chartoff, Hyder A. Jinnah, Bonita L. Blake, Kiyoshi Egami

Publikováno v: Developmental neuroscience. 28(6)

In rodents, activation of L-type calcium channels with ±BayK 8644 causes an unusual behavioral syndrome that includes dystonia and self-biting. Prior studies have linked both of these behaviors to dysfunction of dopaminergic transmission in the stri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2d4496d622aa0a9c7a13adeaa045fa0
https://pubmed.ncbi.nlm.nih.gov/17028428

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