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Tofacitinib inhibits CD4 T cell polarisation to Th1 during priming thereby leading to clinical impact in a model of experimental arthritis

Autor: Bejad, Marija, Bonilha, Caio S., McInnes, Iain B., Garside, Paul, Benson, Robert A.

Objectives: Janus kinases (JAK) are key cell membrane orientated tyrosine kinases that regulate inflammatory responses by transducing signals received by cytokine receptors that directly influence the polarisation and function of Th cells. Tofacitini

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b11420a699d0d1dd3f233b5ae9b57349
https://eprints.gla.ac.uk/248468/3/248468.pdf

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Targeting the Annexin A1-FPR2/ALX pathway for host-directed therapy in dengue disease.

Autor: Vasconcelos Costa, Vivian, Sugimoto, Michelle A., Hubner, Josy, Bonilha, Caio S., Martins Queiroz-Junior, Celso, Gonçalves-Pereira, Marcela Helena, Jianmin Chen, Gobbetti, Thomas, Olinto Libanio Rodrigues, Gisele, Bambirra, Jordana L., Passos, Ingredy B., Machado Lopes, Carla Elizabeth, Moreira, Thaiane P., Bonjour, Kennedy, Melo, Rossana C. N., Oliveira, Milton A. P., Andrade, Marcus Vinicius M., Pires Sousa, Lirlândia, Souza, Danielle Gloria, da Costa Santiago, Helton

Publikováno v: eLife; 3/28/2022, p1-24, 24p

Tofacitinib inhibits CD4 T cell polarisation to Th1 during priming thereby leading to clinical impact in a model of experimental arthritis.

Autor: Bedaj M; Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, Sir Graeme Davies Building, University of Glasgow, UK., Bonilha CS; Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, Sir Graeme Davies Building, University of Glasgow, UK., McInnes IB; Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, Sir Graeme Davies Building, University of Glasgow, UK., Garside P; Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, Sir Graeme Davies Building, University of Glasgow, UK. paul.garside@glasgow.ac.uk., Benson RA; Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, Sir Graeme Davies Building, University of Glasgow, and Research and Development Department, Antibody Analytics Ltd, Newhouse, Lanarkshire, UK.Research and Development Department, Antibody Analytics Ltd, Newhouse, Lanarkshire, U.K.

Publikováno v: Clinical and experimental rheumatology [Clin Exp Rheumatol] 2022 Jul; Vol. 40 (7), pp. 1313-1323. Date of Electronic Publication: 2021 Sep 07.