Water in peripheral TM-interfaces of Orai1-channels triggers pore opening.

Autor: Hopl V; Institute of Biophysics, JKU Life Science Center, Johannes Kepler University Linz, Linz, Austria., Tiffner A; Institute of Biophysics, JKU Life Science Center, Johannes Kepler University Linz, Linz, Austria.; Institute for Physiology and Pathophysiology, Johannes Kepler University Linz, Linz, Austria., Wutscher A; Institute of Biophysics, JKU Life Science Center, Johannes Kepler University Linz, Linz, Austria., Sallinger M; Institute of Biophysics, JKU Life Science Center, Johannes Kepler University Linz, Linz, Austria., Grabmayr H; Institute of Biophysics, JKU Life Science Center, Johannes Kepler University Linz, Linz, Austria., Prantl M; Institute of Biophysics, JKU Life Science Center, Johannes Kepler University Linz, Linz, Austria., Fröhlich M; Institute of Biophysics, JKU Life Science Center, Johannes Kepler University Linz, Linz, Austria., Söllner J; Institute of Biophysics, JKU Life Science Center, Johannes Kepler University Linz, Linz, Austria., Weiß S; Institute of Biophysics, JKU Life Science Center, Johannes Kepler University Linz, Linz, Austria., Najjar H; Institute of Biophysics, JKU Life Science Center, Johannes Kepler University Linz, Linz, Austria., Nazarenko Y; Institute of Biophysics, JKU Life Science Center, Johannes Kepler University Linz, Linz, Austria., Harant S; Institute of Biophysics, JKU Life Science Center, Johannes Kepler University Linz, Linz, Austria., Kriško N; Institute of Biophysics, JKU Life Science Center, Johannes Kepler University Linz, Linz, Austria., Fahrner M; Institute of Biophysics, JKU Life Science Center, Johannes Kepler University Linz, Linz, Austria., Humer C; Institute of Biophysics, JKU Life Science Center, Johannes Kepler University Linz, Linz, Austria., Höglinger C; Institute of Biophysics, JKU Life Science Center, Johannes Kepler University Linz, Linz, Austria., Krobath H; Institute of Theoretical Physics, Johannes Kepler University Linz, Linz, Austria., Bonhenry D; Department of Physics and Materials Science, University of Luxembourg, Luxembourg City, Luxembourg. daniel.bonhenry@gmail.com., Derler I; Institute of Biophysics, JKU Life Science Center, Johannes Kepler University Linz, Linz, Austria. isabella.derler@jku.at.

Publikováno v: Communications biology [Commun Biol] 2024 Nov 16; Vol. 7 (1), pp. 1522. Date of Electronic Publication: 2024 Nov 16.

Essential role of N-terminal SAM regions in STIM1 multimerization and function.

Autor: Sallinger M; Institute of Biophysics, Johannes Kepler University Linz, Linz 4040, Austria., Humer C; Institute of Biophysics, Johannes Kepler University Linz, Linz 4040, Austria., Ong HL; Secretory Physiology Section, National Institute of Dental and Craniofacial Research, NIH, Bethesda, MD 20892., Narayanasamy S; Secretory Physiology Section, National Institute of Dental and Craniofacial Research, NIH, Bethesda, MD 20892., Lin QT; Department of Physiology and Pharmacology, Western University, London, ON N6A5C1, Canada., Fahrner M; Institute of Biophysics, Johannes Kepler University Linz, Linz 4040, Austria., Grabmayr H; Institute of Biophysics, Johannes Kepler University Linz, Linz 4040, Austria., Berlansky S; Institute of Biophysics, Johannes Kepler University Linz, Linz 4040, Austria., Choi S; Secretory Physiology Section, National Institute of Dental and Craniofacial Research, NIH, Bethesda, MD 20892., Schmidt T; Department of Medical Physics and Biophysics, Medical University of Graz, Graz 8010, Austria., Maltan L; Institute of Biophysics, Johannes Kepler University Linz, Linz 4040, Austria., Atzgerstorfer L; Institute of Biophysics, Johannes Kepler University Linz, Linz 4040, Austria., Niederwieser M; Department of Medical Physics and Biophysics, Medical University of Graz, Graz 8010, Austria., Frischauf I; Institute of Biophysics, Johannes Kepler University Linz, Linz 4040, Austria., Romanin C; Institute of Biophysics, Johannes Kepler University Linz, Linz 4040, Austria., Stathopulos PB; Department of Physiology and Pharmacology, Western University, London, ON N6A5C1, Canada., Ambudkar I; Secretory Physiology Section, National Institute of Dental and Craniofacial Research, NIH, Bethesda, MD 20892., Leitner R; Institute of Biophysics, Johannes Kepler University Linz, Linz 4040, Austria., Bonhenry D; Department of Physics and Materials Science, Faculty of Science, Technology and Medicine, University of Luxembourg, Esch-sur-Alzette L1511, Luxembourg., Schindl R; Department of Medical Physics and Biophysics, Medical University of Graz, Graz 8010, Austria.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2024 May 21; Vol. 121 (21), pp. e2318874121. Date of Electronic Publication: 2024 May 16.

Emerging signs of Alzheimer‐like tau hyperphosphorylation and neuroinflammation in the brain post recovery from COVID‐19.

Autor: Qi, Xuetao^1,2 (AUTHOR), Yuan, Shulu¹ (AUTHOR), Ding, Jiuyang^3,4,5 (AUTHOR), Sun, Weiqi¹ (AUTHOR), Shi, Yajiao¹ (AUTHOR), Xing, Yuanwei¹ (AUTHOR), Liu, Zilong¹ (AUTHOR), Yao, Yun^1,2 (AUTHOR), Fu, Su^1,2 (AUTHOR), Sun, Baofei³ (AUTHOR), Qi, Xiaolan⁴ (AUTHOR), Xia, Bing⁵ (AUTHOR), Liu, Fengyu^1,2 (AUTHOR), Yi, Ming^1,2 (AUTHOR), Mao, Jian⁶ (AUTHOR), Wan, You^1,2,6 (AUTHOR) ywan@hsc.pku.edu.cn, Zheng, Jie^1,2,6 (AUTHOR) zhengjiie@hsc.pku.edu.cn

Publikováno v: Aging Cell. Nov2024, Vol. 23 Issue 11, p1-6. 6p.

Twisting gating residues in the Orai pore.

Autor: Bonhenry D; Center for Nanobiology and Structural Biology, Institute of Microbiology, Academy of Sciences of the Czech Republic, CZ-373 33, Nove Hrady, Czech Republic., Schober R; Institute of Biophysics, JKU Life Science Center, Johannes Kepler University Linz, A-4020, Linz, Austria., Schindl R; Gottfried Schatz Research Center, Medical University of Graz, A-8010, Graz, Austria. Electronic address: rainer.schindl@medunigraz.at.

Publikováno v: Cell calcium [Cell Calcium] 2021 Jan; Vol. 93, pp. 102323. Date of Electronic Publication: 2020 Dec 02.

Blockage of Store-Operated Ca ²⁺ Influx by Synta66 is Mediated by Direct Inhibition of the Ca ²⁺ Selective Orai1 Pore.

Autor: Waldherr L; Gottfried Schatz Research Centre, Medical University of Graz, A-8010 Graz, Austria., Tiffner A; Institute of Biophysics, JKU Life Science Centre, Johannes Kepler University Linz, A-4020 Linz, Austria., Mishra D; Centre for Nanobiology and Structural Biology, Academy of Sciences of the Czech Republic, 373 33 Nové Hrady, Czech Republic., Sallinger M; Institute of Biophysics, JKU Life Science Centre, Johannes Kepler University Linz, A-4020 Linz, Austria., Schober R; Gottfried Schatz Research Centre, Medical University of Graz, A-8010 Graz, Austria.; Institute of Biophysics, JKU Life Science Centre, Johannes Kepler University Linz, A-4020 Linz, Austria., Frischauf I; Institute of Biophysics, JKU Life Science Centre, Johannes Kepler University Linz, A-4020 Linz, Austria., Schmidt T; Gottfried Schatz Research Centre, Medical University of Graz, A-8010 Graz, Austria., Handl V; Department of Neurosurgery, Medical University of Graz, A-8010 Graz, Austria., Sagmeister P; Institute of Chemistry, University of Graz, Heinrichstraße 28, A-8010 Graz, Austria., Köckinger M; Institute of Chemistry, University of Graz, Heinrichstraße 28, A-8010 Graz, Austria., Derler I; Institute of Biophysics, JKU Life Science Centre, Johannes Kepler University Linz, A-4020 Linz, Austria., Üçal M; Department of Neurosurgery, Medical University of Graz, A-8010 Graz, Austria., Bonhenry D; Centre for Nanobiology and Structural Biology, Academy of Sciences of the Czech Republic, 373 33 Nové Hrady, Czech Republic., Patz S; Department of Neurosurgery, Medical University of Graz, A-8010 Graz, Austria., Schindl R; Gottfried Schatz Research Centre, Medical University of Graz, A-8010 Graz, Austria.; Institute of Biophysics, JKU Life Science Centre, Johannes Kepler University Linz, A-4020 Linz, Austria.

Publikováno v: Cancers [Cancers (Basel)] 2020 Oct 06; Vol. 12 (10). Date of Electronic Publication: 2020 Oct 06.