Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Bong Geum Jang"'
Publikováno v:
Redox Biology, Vol 73, Iss , Pp 103180- (2024)
This study unveils a novel role of pyrogallol (PG), a recognized superoxide generator, in inducing beta-amyloid (Aβ) secretion in an Alzheimer's disease (AD) cellular model. Contrary to expectations, the analysis of dihydroethidium fluorescence and
Externí odkaz:
https://doaj.org/article/d8e4a2ee503b4fa686a6849ab85b3b75
Autor:
Bong-Geum Jang, Boyoung Choi, Suyeon Kim, Duk-Shin Lee, Jisun Lee, Young Ho Koh, Sangmee Ahn Jo, Ji-Eun Kim, Tae-Cheon Kang, Min-Ju Kim
Publikováno v:
Cells, Vol 11, Iss 16, p 2585 (2022)
There is currently no effective treatment against Alzheimer’s disease (AD), although many strategies have been applied to reduce beta-amyloid (Aβ) levels. Here, we investigated 2,4-diacetylphloroglucinol (DAPG) effects on Aβ levels and mechanisms
Externí odkaz:
https://doaj.org/article/b4ffc042bc394a27b265e06db9ef224f
Publikováno v:
Journal of Functional Foods, Vol 23, Iss , Pp 124-134 (2016)
Beta-amyloid (Aβ) is a major pathogenic molecule in Alzheimer's disease (AD). The mechanisms of Aβ reduction by resveratrol and its analogues, oxyresveratrol and piceatannol were investigated through examination of amyloid precursor protein (APP) p
Externí odkaz:
https://doaj.org/article/394abe1a2fa64a9ca46810c93e663b51
Publikováno v:
Food and Chemical Toxicology. 152:112185
Resveratrol is a drug candidate used for Alzheimer's disease (AD) and shows beneficial effects in various toxicity and production models, although recent clinical trial data did not show satisfactory results. Here we demonstrated the potential side e
Publikováno v:
Journal of Functional Foods, Vol 23, Iss, Pp 124-134 (2016)
Beta-amyloid (Aβ) is a major pathogenic molecule in Alzheimer's disease (AD). The mechanisms of Aβ reduction by resveratrol and its analogues, oxyresveratrol and piceatannol were investigated through examination of amyloid precursor protein (APP) p
Publikováno v:
Journal of molecular neuroscience : MN. 64(4)
Neuroblastoma cell differentiation is a valuable model for studying therapeutic methods in neuroblastoma and the mechanisms of neuronal differentiation. Here, we used trichostatin A (TSA) and sirtinol, which are inhibitors of cHDACs and sirtuins, res
Publikováno v:
Molecular neurobiology. 53(1)
Parkinson's disease (PD) is a common movement disorder among neurodegenerative diseases, involving neuronal cell death in the substantia nigra of the midbrain. Although mechanisms of cell death in PD have been studied, the exact molecular pathogenesi
Publikováno v:
Neuroreport. 25(16)
Beta-amyloid is a major pathogenic molecule for Alzheimer's disease (AD) and can be aggregated into a soluble oligomer, which is a toxic intermediate, before amyloid fibril formation. Beta-amyloid oligomers are associated closely with early synaptic