Pharmacogenomics of clinical response to Natalizumab in multiple sclerosis: a genome-wide multi-centric association study.

Autor: Clarelli F; Laboratory of Human Genetics of Neurological Disorders, IRCCS San Raffaele Scientific Institute, Via Olgettina 60, Milan, Italy., Corona A; Laboratory of Precision Medicine of Neurological Diseases, Department of Health Science, University of Milan, Milan, Italy.; CRC 'Aldo Ravelli' for Experimental Brain Therapeutics, Department of Health Science, University of Milan, Milan, Italy., Pääkkönen K; Institute for Molecular Medicine Finland (FIMM), University of FI Helsinki, Helsinki, Finland., Sorosina M; Laboratory of Human Genetics of Neurological Disorders, IRCCS San Raffaele Scientific Institute, Via Olgettina 60, Milan, Italy., Zollo A; Laboratory of Precision Medicine of Neurological Diseases, Department of Health Science, University of Milan, Milan, Italy.; CRC 'Aldo Ravelli' for Experimental Brain Therapeutics, Department of Health Science, University of Milan, Milan, Italy., Piehl F; The Karolinska Neuroimmunology & Multiple Sclerosis Centre, Department of Clinical Neuroscience, Karolinska Institutet, Center for Molecular Medicine, Karolinska University Hospital, Visionsgatan 18, 171 76, Stockholm, Sweden., Olsson T; The Karolinska Neuroimmunology & Multiple Sclerosis Centre, Department of Clinical Neuroscience, Karolinska Institutet, Center for Molecular Medicine, Karolinska University Hospital, Visionsgatan 18, 171 76, Stockholm, Sweden., Stridh P; The Karolinska Neuroimmunology & Multiple Sclerosis Centre, Department of Clinical Neuroscience, Karolinska Institutet, Center for Molecular Medicine, Karolinska University Hospital, Visionsgatan 18, 171 76, Stockholm, Sweden., Jagodic M; The Karolinska Neuroimmunology & Multiple Sclerosis Centre, Department of Clinical Neuroscience, Karolinska Institutet, Center for Molecular Medicine, Karolinska University Hospital, Visionsgatan 18, 171 76, Stockholm, Sweden., Hemmer B; Department of Neurology, School of Medicine, Technical University of Munich, Klinikum Rechts Der Isar, Ismaninger Str. 22, Munich, Germany.; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany., Gasperi C; Department of Neurology, School of Medicine, Technical University of Munich, Klinikum Rechts Der Isar, Ismaninger Str. 22, Munich, Germany., Harroud A; Department of Neurology and Neurosurgery, McGill University, Montréal, QC, Canada., Shchetynsky K; The Karolinska Neuroimmunology & Multiple Sclerosis Centre, Department of Clinical Neuroscience, Karolinska Institutet, Center for Molecular Medicine, Karolinska University Hospital, Visionsgatan 18, 171 76, Stockholm, Sweden., Mingione A; Laboratory of Precision Medicine of Neurological Diseases, Department of Health Science, University of Milan, Milan, Italy.; CRC 'Aldo Ravelli' for Experimental Brain Therapeutics, Department of Health Science, University of Milan, Milan, Italy., Mascia E; Laboratory of Human Genetics of Neurological Disorders, IRCCS San Raffaele Scientific Institute, Via Olgettina 60, Milan, Italy., Misra K; Laboratory of Human Genetics of Neurological Disorders, IRCCS San Raffaele Scientific Institute, Via Olgettina 60, Milan, Italy., Giordano A; Laboratory of Human Genetics of Neurological Disorders, IRCCS San Raffaele Scientific Institute, Via Olgettina 60, Milan, Italy.; Neurology Unit, IRCCS San Raffaele Scientific Institute, Via Olgettina 60, 20132, Milan, Italy., Mazzieri MLT; Laboratory of Precision Medicine of Neurological Diseases, Department of Health Science, University of Milan, Milan, Italy.; CRC 'Aldo Ravelli' for Experimental Brain Therapeutics, Department of Health Science, University of Milan, Milan, Italy., Priori A; CRC 'Aldo Ravelli' for Experimental Brain Therapeutics, Department of Health Science, University of Milan, Milan, Italy.; Clinical Neurology Unit, Azienda Socio-Sanitaria Territoriale Santi Paolo E Carlo and Department of Health Sciences, University of Milan, Milan, Italy., Saarela J; Institute for Molecular Medicine Finland (FIMM), University of FI Helsinki, Helsinki, Finland., Kockum I; The Karolinska Neuroimmunology & Multiple Sclerosis Centre, Department of Clinical Neuroscience, Karolinska Institutet, Center for Molecular Medicine, Karolinska University Hospital, Visionsgatan 18, 171 76, Stockholm, Sweden., Filippi M; Neurology Unit, IRCCS San Raffaele Scientific Institute, Via Olgettina 60, 20132, Milan, Italy.; Neurorehabilitation Unit, IRCCS San Raffaele Scientific Institute, Via Olgettina 48, Milan, Italy.; Neurophysiology Service, IRCCS San Raffaele Scientific Institute, Via Olgettina 60, Milan, Italy.; Neuroimaging Research Unit, Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Via Olgettina 60, Milan, Italy.; Vita-Salute San Raffaele University, Via Olgettina, 60, Milan, Italy., Esposito F; Laboratory of Human Genetics of Neurological Disorders, IRCCS San Raffaele Scientific Institute, Via Olgettina 60, Milan, Italy. esposito.federica@hsr.it.; Neurology Unit, IRCCS San Raffaele Scientific Institute, Via Olgettina 60, 20132, Milan, Italy. esposito.federica@hsr.it., Boneschi FGM; Laboratory of Precision Medicine of Neurological Diseases, Department of Health Science, University of Milan, Milan, Italy. filippo.martinelli@unimi.it.; CRC 'Aldo Ravelli' for Experimental Brain Therapeutics, Department of Health Science, University of Milan, Milan, Italy. filippo.martinelli@unimi.it.; Clinical Neurology Unit, Azienda Socio-Sanitaria Territoriale Santi Paolo E Carlo and Department of Health Sciences, University of Milan, Milan, Italy. filippo.martinelli@unimi.it.

Publikováno v: Journal of neurology [J Neurol] 2024 Nov; Vol. 271 (11), pp. 7250-7263. Date of Electronic Publication: 2024 Sep 12.