Cell-free plasma telomere length correlated with the risk of cardiovascular events using machine learning classifiers

Autor: Mengjun Dai, Kangbo Li, Mesud Sacirovic, Claudia Zemmrich, Oliver Ritter, Peter Bramlage, Anja Bondke Persson, Eva Buschmann, Ivo Buschmann, Philipp Hillmeister

Publikováno v: Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)

Abstract This retrospective study explored the association between circulating cell-free plasma telomere length (cf-TL) and coronary artery disease (CAD) and heart failure (HF). Data from 518 participants were collected, including clinical and labora

Externí odkaz: https://doaj.org/article/c753d46b6db245fbb150fe2af4e9497e

Rivaroxaban vs Vitamin K Antagonist in Patients With Atrial Fibrillation and Advanced Chronic Kidney Disease

Autor: Laetitia, Albano, Catherine, Albert, Joachim, Alexandre, Ayham, Al-Zoebi, Cedric, Annweiler, Johann, Auer, Sanjeet, Balgobin, Joachim, Beige, Ahmed, Berami, Jean-Baptiste, Berneau, Patrick, Biggar, Ralf, Birkemeyer, Christina, Bondke, Renate, Bonin-Schnabel, Hendrik, Bonnemeier, Marc, Bouiller, Anne-Sophie, Boureau, Johannes, Brachmann, Jörg, Brosche, Sebastien, Caudmont, Guillaume, Cayla, Vianney, Charpy, Joel, Constans, Jean-Baptiste, Dally, Guillaume, De Geeter, Fédéric, Debelle, Eric, Decoulx, Nicolas, Delarche, Georg, Delle Karth, Pascal, Delsart, Michael, Derndorfer, Laurent, Desprets, Jean-Guillaume, Dillinger, Camille, Dubart, Katrin, Eberhard, Sabine, Eichinger-Hasenauer, Volker, Eissing, Christiane, Erley, Jean-Baptiste, Esteve, Emile, Ferrari, Virginie, Fossey-Diaz, Stéphane, Fromentin, Karim, Gallouj, Estelle, Gandjbakhch, Anne-Sophie, Garnier, Laure, Gilis, Bertrand, Gondouin, Franziska, Grundmann, Isabelle, Gueffet, Sebastian, Haaß, Didier, Haguenhauer, Thierry, Hannedouche, Georg, Häusler Karl, Gerd-Ulrich, Heinz, Philipp, Herold, Klaus, Hertting, Etienne, Hoffer, Joachim, Hoyer, Burkhard, Hügl, Sybille, Jänsch, Georges, Jean-Louis, Michael, Jeserich, Werner, Jung, Samuel, Kassis, Bernd-Thomas, Kellner, Marcus, Ketteler, Thomas, Kielstein Jan, René, Koning, Fabian, Krämer, Jean-Marie, Krzesinski, Ulrich, Lammers, Jean-Marie, Lefebvre, Eric, Legrand, Matthias, Leschke, Bernhard-Paul, Lodde, Christian, Maalouli, Christian, Mahnkopf, Sebastien, Mailliez, Jacques, Mansourati, Eloi, Marijon, Christian, Meyer, Detlev, Moll, Gilles, Montalescot, Serge, Motte, Vincent, Mouquet, Krassen, Nedeltchev, Anna, Neykova, Jörg, Nothroff, Raphael, Poyet, Roland, Prondzinsky, Ursula, Rauch-Kröhnert, Frank, Richard, Werner, Rieker, Andrea, Rocco, Thomas, Rostock, Daniel, Scherr, Axel, Schlitt, Hans, Schmidt-Gürtler, Norbert, Schön, Johannes, Schwab, Carsten, Schwencke, Peter, Schwimmbeck, G, Schwinger Robert H., Andreas, Schwittay, Igor, Sibon, Ulrike, Spengler, Alexander, Stadelmann, Clemens, Steinwender, Reinhard, Stöhring, Jean-Claude, Stolear, Guillaume, Taldir, Jean-Michel, Tartière, Serge, Treille, Pierre, Tremolieres, Zead, Tubail, Xavier, Warling, Morgane, Wetzstein, Adrian, Zaman, Claudia, Zemmrich, Kreutz, Reinhold, Deray, Gilbert, Floege, Jürgen, Gwechenberger, Marianne, Hahn, Kai, Luft, Andreas R., Persson, Pontus, Axthelm, Christoph, Beer, Juerg Hans, Bergler-Klein, Jutta, Lellouche, Nicolas, Taggeselle, Jens, Coleman, Craig I., Beyer-Westendorf, Jan

Publikováno v: In JACC: Advances February 2024 3(2)

Autophagy-related genes analysis reveals potential biomarkers for prediction of the impaired walking capacity of peripheral arterial disease

Autor: Mengjun Dai, Kangbo Li, Mesud Sacirovic, Claudia Zemmrich, Eva Buschmann, Oliver Ritter, Peter Bramlage, Anja Bondke Persson, Ivo Buschmann, Philipp Hillmeister

Publikováno v: BMC Medicine, Vol 21, Iss 1, Pp 1-18 (2023)

Abstract Background The role of autophagy and autophagy-related genes in peripheral arterial disease (PAD) remains unknown and may be of diagnostic and prognostic value. The aim of this study is to investigate the relationship between autophagy and P

Externí odkaz: https://doaj.org/article/a608b37b436c4f8782f788c47c8c78ed

Cell-free plasma telomere length correlated with the risk of cardiovascular events using machine learning classifiers.

Autor: Dai, Mengjun, Li, Kangbo, Sacirovic, Mesud, Zemmrich, Claudia, Ritter, Oliver, Bramlage, Peter, Persson, Anja Bondke, Buschmann, Eva, Buschmann, Ivo, Hillmeister, Philipp

Publikováno v: Scientific Reports; 12/5/2024, Vol. 14 Issue 1, p1-11, 11p

Design and synthesis of selective CDK7 inhibitors

Autor: Bondke, Alexander

Cyclin-dependent protein kinases (CDKs) have a central role in the regulation of cell proliferation, apoptosis and gene expression. CDK7, in particular, not only regulates the activation of the cell cycle kinases CDK1, CDK2, CDK4 and CDK6, but is als

Externí odkaz: http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.702760