Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Bondinell, William E."'
Autor:
Keenan, Richard M., Miller, William H., Barton, Linda S., Bondinell, William E., Cousins, Russell D., Eppley, Daniel F., Hwang, Shing-Mei, Kwon, Chet, Lago, M.Amparo, Nguyen, Thomas T., Smith, Brian R., Uzinskas, Irene N., Yuan, Catherine C.K.
Publikováno v:
In Bioorganic & Medicinal Chemistry Letters 1999 9(13):1801-1806
Autor:
Miller, William H., Bondinell, William E., Cousins, Russell D., Erhard, Karl F., Jakas, Dalia R., Keenan, Richard M., Ku, Thomas W., Newlander, Kenneth A., Ross, Stephen T., Haltiwanger, R.Curtis, Bradbeer, Jeremy, Drake, Fred H., Gowen, Maxine, Hoffman, Sandra J., Hwang, Shing-Mei, James, Ian E., Lark, Michael W., Lechowska, Beata, Rieman, David J., Stroup, George B., Vasko-Moser, Janice A., Zembryki, Denise L., Azzarano, Leonard M., Adams, Paula C., Salyers, Kevin L., Smith, Brian R., Ward, Keith W., Johanson, Kyung O., Huffaman, William F.
Publikováno v:
In Bioorganic & Medicinal Chemistry Letters 1999 9(13):1807-1812
Autor:
Irene N. Uzinskas, Russell D. Cousins, Bondinell William E, Linda S. Barton, M. Amparo Lago, Brian R. Smith, Chet Kwon, Richard M. Keenan, Shing-Mei Hwang, William H. Miller, Catherine C.K. Yuan, Daniel F. Eppley, Thomas T. Nguyen
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 9:1801-1806
A peptide RGD analog containing a novel 2-aminopyridine arginine mimetic was discovered to have good affinity and selectivity for the vitronectin receptor. Incorporation of the 2-aminopyridine arginine mimetic into the 3-oxo-1,4-benzodiazepine-2-acet
Autor:
David J. Rieman, William F. Huffaman, Kevin L. Salyers, Richard M. Keenan, Michael W. Lark, Janice A. Vasko-Moser, Thomas W. Ku, Maxine Gowen, Leonard M. Azzarano, Karl F. Erhard, Stephen T. Ross, Denise Zembryki, Bradbeer Jeremy N, Bondinell William E, Shing-Mei Hwang, William H. Miller, Kenneth A. Newlander, George B. Stroup, Beata Lechowska, Fred H. Drake, Keith W. Ward, Kyung O. Johanson, Brian R. Smith, Paula C. Adams, Ian E. James, R. Curtis Haltiwanger, Russell D. Cousins, Dalia R. Jakas, Sandra J. Hoffman
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 9:1807-1812
A new series of potent nonpeptide vitronectin receptor antagonists, based on a novel carbocyclic Gly-Asp mimetic, has been discovered. A representative of this series, SB 265123 (4), has 100% oral bioavailability in rats, and is orally active in vivo
Autor:
Thomas W. Ku, Dalia R. Jakas, William H. Miller, Valerie A. Reader, James F. Callahan, Catherine C.K. Yuan, Brian R. Smith, Dennis T. Takata, Raul R. Calvo, Thomas T. Nguyen, Bondinell William E, Fadia E. Ali, Russell D. Cousins, S M Hwang, Chet Kwon, Steven T. Ross, Irene N. Uzinskas, David J. Rieman, M. Amparo Lago, Richard M. Keenan
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 8:3165-3170
In a 3-oxo-1,4-benzodiazepine-2-acetic acid series of vitronectin receptor (alpha v beta 3) antagonists containing a benzimidazole as a novel arginine mimetic, we examined the effects of benzimidazole modifications and amide substitutions on both act
Autor:
Joseph W. Venslavsky, Bondinell William E, William F. Huffman, F. E. Ali, T. W. Ku, Karl F. Erhard, Catherine C.K. Yuan
Publikováno v:
Tetrahedron Letters. 38:3131-3134
An alternate enantiospecific synthesis of methyl (S)-7-tert-butoxycarbonyl-2,3,4,5-tetrahydro-4-methyl-3-oxo-1H-1,4-benzodiazepine-2-acetate ( 5 ) is reported. The key step, which involves an intermolecular displacement of the activated aryl fluoride
Autor:
Philip L. Smith, Andrew J. Nichols, Tobias Oregon Yellin, Kenneth A. Newlander, Raul R. Calvo, James Samanen, Irene N. Uzinskas, Bondinell William E, Chao-Pin Lee, Michael W. Parker, Dalia R. Jakas
Publikováno v:
Advanced Drug Delivery Reviews. 23:133-142
A series of potent, high affinity GPIIb/IIIa antagonists were evaluated for intestinal permeability in vitro using rabbit intestinal strips mounted in the Ussing Chamber. In this series of compounds, structural modifications were found to impact inte
Autor:
Angela S. Wong, James F. Callahan, William H. Miller, Catherine C.K. Yuan, Raul R. Calvo, Janice A. Vasko-Moser, Thomas W. Ku, Richard E. Valocik, Dennis T. Takata, Richard M. Keenan, Drake S. Eggleston, Michael F. Parker, Southall Linda Sue, S M Hwang, Paul F. Koster, William F. Huffman, Tobias Oregon Yellin, Chet Kwon, Irene N. Uzinskas, Bondinell William E, Fadia E. Ali, Dalia R. Jakas, Andrew J. Nichols, James Samanen, R. Curtis Haltiwanger, Kenneth A. Newlander
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 6:2481-2486
In an investigation of the contribution of N-1 to the binding, antiaggregatory, and oral activity in 3-oxo-1,4-benzodiazepine-2-acetic acid based GPIIb/IIIa antagonists, a series of 2-benzazepine analogs, wherein N-1 of the 1,4-benzodiazepine nucleus
Autor:
Jeffrey K. Kerns, Widdowson Katherine L, Patricia L. Podolin, Paul M. Keller, Benoit Riflade, Neysa Nevins, Attiq Rahman, Dennis S. Yamashita, Qi Jin, Bondinell William E, Thaddeus A. Tomaszek, Xiaoyang Dong, Laura Mitchell, Hong Nie, Donald C. Carpenter
Publikováno v:
Bioorganicmedicinal chemistry letters. 21(15)
A series of azepanone inhibitors of cathepsin S is described. Selectivity over both cathepsin K and cathepsin L was achieved by varying the P2 substituent. Ultimately, a balanced potency and selectivity profile was achieved in compound 39 possessing
Autor:
F. E. Ali, William F. Huffman, Catherine C.K. Yuan, Joseph W. Venslavsky, Bondinell William E, T. W. Ku, Karl F. Erhard
Publikováno v:
ChemInform. 28
An alternate enantiospecific synthesis of methyl (S)-7-tert-butoxycarbonyl-2,3,4,5-tetrahydro-4-methyl-3-oxo-1H-1,4-benzodiazepine-2-acetate ( 5 ) is reported. The key step, which involves an intermolecular displacement of the activated aryl fluoride