Heme biosynthesis by the malarial parasite - Import of delta-aminolevulinate dehydrase from the host red cell

Autor: Bonday, ZQ, Taketani, S, Gupta, PD, Padmanaban, G

Publikováno v: IndraStra Global.

The mouse and human malarial parasites, Plasmodium berghei and Plasmodium falciparum, respectively, synthesize heme de novo following the standard pathway observed in animals despite the availability of large amounts of heme, derived from red cell he

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=issn23813652::027c577b07ff296e93adb0b357970aea
http://eprints.iisc.ac.in/19307/1/Heme.pdf

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PRMT5 inhibition disrupts splicing and stemness in glioblastoma.

Autor: Sachamitr P; Developmental and Stem Cell Biology Program and Arthur and Sonia Labatt Brain Tumor Research Centre, The Hospital for Sick Children, Toronto, ON, Canada.; Structural Genomics Consortium, University of Toronto, Toronto, ON, Canada., Ho JC; Structural Genomics Consortium, University of Toronto, Toronto, ON, Canada., Ciamponi FE; Center for Molecular Biology and Genetic Engineering, University of Campinas (UNICAMP), Campinas, Brazil.; The Structural Genomics Consortium, University of Campinas (UNICAMP), Campinas, Brazil., Ba-Alawi W; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada., Coutinho FJ; Developmental and Stem Cell Biology Program and Arthur and Sonia Labatt Brain Tumor Research Centre, The Hospital for Sick Children, Toronto, ON, Canada., Guilhamon P; Developmental and Stem Cell Biology Program and Arthur and Sonia Labatt Brain Tumor Research Centre, The Hospital for Sick Children, Toronto, ON, Canada.; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada., Kushida MM; Developmental and Stem Cell Biology Program and Arthur and Sonia Labatt Brain Tumor Research Centre, The Hospital for Sick Children, Toronto, ON, Canada., Cavalli FMG; Developmental and Stem Cell Biology Program and Arthur and Sonia Labatt Brain Tumor Research Centre, The Hospital for Sick Children, Toronto, ON, Canada., Lee L; Developmental and Stem Cell Biology Program and Arthur and Sonia Labatt Brain Tumor Research Centre, The Hospital for Sick Children, Toronto, ON, Canada., Rastegar N; Developmental and Stem Cell Biology Program and Arthur and Sonia Labatt Brain Tumor Research Centre, The Hospital for Sick Children, Toronto, ON, Canada., Vu V; Structural Genomics Consortium, University of Toronto, Toronto, ON, Canada.; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada., Sánchez-Osuna M; Institute for Research in Immunology and Cancer, Université de Montréal, Montreal, QC, Canada., Coulombe-Huntington J; Institute for Research in Immunology and Cancer, Université de Montréal, Montreal, QC, Canada., Kanshin E; Institute for Research in Immunology and Cancer, Université de Montréal, Montreal, QC, Canada., Whetstone H; Developmental and Stem Cell Biology Program and Arthur and Sonia Labatt Brain Tumor Research Centre, The Hospital for Sick Children, Toronto, ON, Canada., Durand M; RNomics Platform, Université de Sherbrooke, Sherbrooke, QC, Canada., Thibault P; RNomics Platform, Université de Sherbrooke, Sherbrooke, QC, Canada., Hart K; Structural Genomics Consortium, University of Toronto, Toronto, ON, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada., Mangos M; Structural Genomics Consortium, University of Toronto, Toronto, ON, Canada., Veyhl J; Structural Genomics Consortium, University of Toronto, Toronto, ON, Canada., Chen W; Structural Genomics Consortium, University of Toronto, Toronto, ON, Canada., Tran N; Structural Genomics Consortium, University of Toronto, Toronto, ON, Canada., Duong BC; Structural Genomics Consortium, University of Toronto, Toronto, ON, Canada., Aman AM; Ontario Institute for Cancer Research, Toronto, ON, Canada., Che X; Developmental and Stem Cell Biology Program and Arthur and Sonia Labatt Brain Tumor Research Centre, The Hospital for Sick Children, Toronto, ON, Canada., Lan X; Developmental and Stem Cell Biology Program and Arthur and Sonia Labatt Brain Tumor Research Centre, The Hospital for Sick Children, Toronto, ON, Canada., Whitley O; The Donnelly Centre, University of Toronto, Toronto, ON, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada., Zaslaver O; The Donnelly Centre, University of Toronto, Toronto, ON, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada., Barsyte-Lovejoy D; Structural Genomics Consortium, University of Toronto, Toronto, ON, Canada.; Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, Canada., Richards LM; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada., Restall I; Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.; Department of Cell Biology and Anatomy, University of Calgary, Calgary, AB, Canada., Caudy A; The Donnelly Centre, University of Toronto, Toronto, ON, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada.; Maple Flavored Solutions, LLC, Stony Brook, NY, USA., Röst HL; The Donnelly Centre, University of Toronto, Toronto, ON, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada., Bonday ZQ; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN, USA., Bernstein M; Division of Neurosurgery, Department of Surgery, University of Toronto, Toronto, ON, Canada.; Division of Neurosurgery, Toronto Western Hospital, University Health Network, Toronto, ON, Canada., Das S; Division of Neurosurgery, Department of Surgery, University of Toronto, Toronto, ON, Canada.; Division of Neurosurgery, Department of Surgery, St. Michael's Hospital, Toronto, ON, Canada.; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada., Cusimano MD; Division of Neurosurgery, Department of Surgery, St. Michael's Hospital, Toronto, ON, Canada., Spears J; Division of Neurosurgery, Department of Surgery, University of Toronto, Toronto, ON, Canada.; Department of Medical Imaging, St. Michael's Hospital, University of Toronto, Toronto, ON, Canada., Bader GD; The Donnelly Centre, University of Toronto, Toronto, ON, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada., Pugh TJ; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada.; Ontario Institute for Cancer Research, Toronto, ON, Canada., Tyers M; Institute for Research in Immunology and Cancer, Université de Montréal, Montreal, QC, Canada., Lupien M; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada.; Ontario Institute for Cancer Research, Toronto, ON, Canada., Haibe-Kains B; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada.; Ontario Institute for Cancer Research, Toronto, ON, Canada.; Department of Computer Science, University of Toronto, Toronto, ON, Canada.; Vector Institute, Toronto, ON, Canada., Artee Luchman H; Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.; Department of Cell Biology and Anatomy, University of Calgary, Calgary, AB, Canada.; Clark H. Smith Brain Tumor Centre, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada., Weiss S; Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.; Department of Cell Biology and Anatomy, University of Calgary, Calgary, AB, Canada.; Clark H. Smith Brain Tumor Centre, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada., Massirer KB; Center for Molecular Biology and Genetic Engineering, University of Campinas (UNICAMP), Campinas, Brazil.; The Structural Genomics Consortium, University of Campinas (UNICAMP), Campinas, Brazil., Prinos P; Structural Genomics Consortium, University of Toronto, Toronto, ON, Canada. takis.prinos@utoronto.ca., Arrowsmith CH; Structural Genomics Consortium, University of Toronto, Toronto, ON, Canada. cheryl.arrowsmith@uhnresearch.ca.; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada. cheryl.arrowsmith@uhnresearch.ca.; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada. cheryl.arrowsmith@uhnresearch.ca., Dirks PB; Developmental and Stem Cell Biology Program and Arthur and Sonia Labatt Brain Tumor Research Centre, The Hospital for Sick Children, Toronto, ON, Canada. peter.dirks@sickkids.ca.; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada. peter.dirks@sickkids.ca.; Division of Neurosurgery, Department of Surgery, University of Toronto, Toronto, ON, Canada. peter.dirks@sickkids.ca.; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada. peter.dirks@sickkids.ca.; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada. peter.dirks@sickkids.ca.; Division of Neurosurgery, The Hospital for Sick Children, Toronto, ON, Canada. peter.dirks@sickkids.ca.

Publikováno v: Nature communications [Nat Commun] 2021 Feb 12; Vol. 12 (1), pp. 979. Date of Electronic Publication: 2021 Feb 12.

Regulation of constitutive and alternative splicing by PRMT5 reveals a role for Mdm4 pre-mRNA in sensing defects in the spliceosomal machinery.

Autor: Bezzi M; Division of Cancer Genetics and Therapeutics, Laboratory of Chromatin, Epigenetics, and Differentiation, Institute of Molecular and Cell Biology (IMCB), A*STAR (Agency for Science, Technology, and Research), Singapore 138673, Singapore;, Teo SX, Muller J, Mok WC, Sahu SK, Vardy LA, Bonday ZQ, Guccione E

Publikováno v: Genes & development [Genes Dev] 2013 Sep 01; Vol. 27 (17), pp. 1903-16.