Genome-wide association analysis provides insights into the molecular etiology of dilated cardiomyopathy.

Autor: Zheng SL; National Heart and Lung Institute, Imperial College London, London, UK.; MRC Laboratory of Medical Sciences, London, UK.; Royal Brompton & Harefield Hospitals, Guy's and St. Thomas' NHS Foundation Trust, London, UK., Henry A; Institute of Cardiovascular Science, University College London, London, UK.; Institute of Health Informatics, University College London, London, UK., Cannie D; Institute of Cardiovascular Science, University College London, London, UK.; Barts Heart Centre, St Bartholomew's Hospital, London, UK., Lee M; National Heart and Lung Institute, Imperial College London, London, UK., Miller D; Division of Biosciences, University College London, London, UK., McGurk KA; National Heart and Lung Institute, Imperial College London, London, UK.; MRC Laboratory of Medical Sciences, London, UK.; Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA., Bond I; Institute of Cardiovascular Science, University College London, London, UK., Xu X; National Heart and Lung Institute, Imperial College London, London, UK.; MRC Laboratory of Medical Sciences, London, UK., Issa H; Institute of Health Informatics, University College London, London, UK., Francis C; National Heart and Lung Institute, Imperial College London, London, UK.; Royal Brompton & Harefield Hospitals, Guy's and St. Thomas' NHS Foundation Trust, London, UK., De Marvao A; National Heart and Lung Institute, Imperial College London, London, UK.; MRC Laboratory of Medical Sciences, London, UK.; Royal Brompton & Harefield Hospitals, Guy's and St. Thomas' NHS Foundation Trust, London, UK., Theotokis PI; National Heart and Lung Institute, Imperial College London, London, UK.; MRC Laboratory of Medical Sciences, London, UK.; Royal Brompton & Harefield Hospitals, Guy's and St. Thomas' NHS Foundation Trust, London, UK., Buchan RJ; National Heart and Lung Institute, Imperial College London, London, UK.; MRC Laboratory of Medical Sciences, London, UK.; Royal Brompton & Harefield Hospitals, Guy's and St. Thomas' NHS Foundation Trust, London, UK., Speed D; Quantitative Genetics and Genomics, Aarhus University, Aarhus, Denmark., Abner E; Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia., Adams L; Geisinger Health System, Danville, PA, USA., Aragam KG; Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA.; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA., Ärnlöv J; Department of Neurobiology, Care Sciences and Society/Section of Family Medicine and Primary Care, Karolinska Institutet, Stockholm, Sweden.; School of Health and Social Sciences, Dalarna University, Falun, Sweden., Raja AA; Department of Cardiology, The Heart Centre, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark., Backman JD; Analytical Genetics, Regeneron Genetics Center, Tarrytown, NY, USA., Baksi J; Royal Brompton & Harefield Hospitals, Guy's and St. Thomas' NHS Foundation Trust, London, UK., Barton PJR; National Heart and Lung Institute, Imperial College London, London, UK.; MRC Laboratory of Medical Sciences, London, UK.; Royal Brompton & Harefield Hospitals, Guy's and St. Thomas' NHS Foundation Trust, London, UK., Biddinger KJ; Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA.; Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA., Boersma E; Erasmus MC, Cardiovascular Institute, Thorax Center, Department of Cardiology, Utrecht, the Netherlands., Brandimarto J; Penn Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Brunak S; Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Bundgaard H; Department of Cardiology, The Heart Centre, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark., Carey DJ; Department of Molecular and Functional Genomics, Geisinger, Danville, PA, USA., Charron P; Sorbonne Research Unit on Cardiovascular Disorders, Metabolism and Nutrition, Team Genomics & Pathophysiology of Cardiovascular Diseases, ICAN Institute for Cardiometabolism and Nutrition, Paris, France.; APHP, Department of Genetics, Pitié-Salpêtrière Hospital, Paris, France., Cook JP; Department of Biostatistics, University of Liverpool, Liverpool, UK., Cook SA; National Heart and Lung Institute, Imperial College London, London, UK.; MRC Laboratory of Medical Sciences, London, UK.; Royal Brompton & Harefield Hospitals, Guy's and St. Thomas' NHS Foundation Trust, London, UK., Denaxas S; Institute of Health Informatics, University College London, London, UK.; Health Data Research UK, University College London, London, UK.; British Heart Foundation Data Science Centre, London, UK.; The National Institute for Health Research University College London Hospitals Biomedical Research Centre, University College London, London, UK., Deleuze JF; Centre National de Recherche en Génomique Humaine (CNRGH), Institut de Biologie François Jacob, CEA, Université Paris-Saclay, Evry, France.; Laboratory of Excellence GENMED (Medical Genomics), Paris, France.; Centre d'Etude du Polymorphisme Humain, Fondation Jean Dausset, Paris, France., Doney AS; Division of Molecular & Clinical Medicine, University of Dundee, Ninewells Hospital and Medical School, Dundee, UK., Elliott P; Institute of Cardiovascular Science, University College London, London, UK.; Barts Heart Centre, St Bartholomew's Hospital, London, UK., Erikstrup C; Department of Clinical Immunology, Aarhus University Hospital, Aarhus, Denmark.; Deparment of Clinical Medicine, Aarhus University Hospital, Aarhus, Denmark., Esko T; Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia.; Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA., Farber-Eger EH; Vanderbilt Institute for Clinical and Translational Research, Vanderbilt University Medical Center, Nashville, TN, USA., Finan C; Institute of Cardiovascular Science, University College London, London, UK., Garnier S; Sorbonne Research Unit on Cardiovascular Disorders, Metabolism and Nutrition, Team Genomics & Pathophysiology of Cardiovascular Diseases, ICAN Institute for Cardiometabolism and Nutrition, Paris, France., Ghouse J; Department of Cardiology, The Heart Centre, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark., Giedraitis V; Department of Public Health and Caring Sciences, Geriatrics, Uppsala, Sweden., Guðbjartsson DF; deCODE genetics/Amgen Inc., Reykjavik, Iceland.; School of Engineering and Natural Sciences, University of Iceland, Reykjavik, Iceland., Haggerty CM; Department of Molecular and Functional Genomics, Geisinger, Danville, PA, USA., Halliday BP; National Heart and Lung Institute, Imperial College London, London, UK.; Royal Brompton & Harefield Hospitals, Guy's and St. Thomas' NHS Foundation Trust, London, UK., Helgadottir A; deCODE genetics/Amgen Inc., Reykjavik, Iceland., Hemingway H; Institute of Health Informatics, University College London, London, UK.; Health Data Research UK, University College London, London, UK., Hillege HL; Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands., Kardys I; Erasmus MC, Cardiovascular Institute, Thorax Center, Department of Cardiology, Utrecht, the Netherlands., Lind L; Department of Medical Sciences, Uppsala University, Uppsala, Sweden., Lindgren CM; Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Big Data Institute at the Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford, UK.; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK., Lowery BD; Vanderbilt Institute for Clinical and Translational Research, Vanderbilt University Medical Center, Nashville, TN, USA., Manisty C; Institute of Cardiovascular Science, University College London, London, UK.; Barts Heart Centre, St Bartholomew's Hospital, London, UK., Margulies KB; Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Moon JC; Institute of Cardiovascular Science, University College London, London, UK.; Barts Heart Centre, St Bartholomew's Hospital, London, UK., Mordi IR; Division of Molecular & Clinical Medicine, University of Dundee, Ninewells Hospital and Medical School, Dundee, UK., Morley MP; Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Morris AD; Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK., Morris AP; Centre for Genetics and Genomics Versus Arthritis, Centre for Musculoskeletal Research, University of Manchester, Manchester, UK., Morton L; Cardiovascular Research, Regeneron Pharmaceuticals, Tarrytown, NY, USA., Noursadeghi M; Research Department of Infection, Division of Infection and Immunity, University College London, London, UK., Ostrowski SR; Department of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen University Hospital, Copenhagen, Denmark., Owens AT; Penn Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Palmer CNA; Division of Population Health and Genomics, University of Dundee, Ninewells Hospital and Medical School, Dundee, UK., Pantazis A; Royal Brompton & Harefield Hospitals, Guy's and St. Thomas' NHS Foundation Trust, London, UK., Pedersen OBV; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen University Hospital, Copenhagen, Denmark.; Department of Clinical Immunology, Zealand University Hospital, Køge, Denmark., Prasad SK; National Heart and Lung Institute, Imperial College London, London, UK.; Royal Brompton & Harefield Hospitals, Guy's and St. Thomas' NHS Foundation Trust, London, UK., Shekhar A; Cardiovascular Research, Regeneron Pharmaceuticals, Tarrytown, NY, USA., Smelser DT; Department of Molecular and Functional Genomics, Geisinger, Danville, PA, USA., Srinivasan S; Division of Population Health and Genomics, University of Dundee, Ninewells Hospital and Medical School, Dundee, UK., Stefansson K; deCODE genetics/Amgen Inc., Reykjavik, Iceland.; Department of Medicine, University of Iceland, Reykjavik, Iceland., Sveinbjörnsson G; deCODE genetics/Amgen Inc., Reykjavik, Iceland., Syrris P; Institute of Cardiovascular Science, University College London, London, UK., Tammesoo ML; Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia., Tayal U; National Heart and Lung Institute, Imperial College London, London, UK.; Royal Brompton & Harefield Hospitals, Guy's and St. Thomas' NHS Foundation Trust, London, UK., Teder-Laving M; Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia., Thorgeirsson G; deCODE genetics/Amgen Inc., Reykjavik, Iceland.; Department of Medicine, University of Iceland, Reykjavik, Iceland., Thorsteinsdottir U; deCODE genetics/Amgen Inc., Reykjavik, Iceland.; Department of Medicine, University of Iceland, Reykjavik, Iceland., Tragante V; deCODE genetics/Amgen Inc., Reykjavik, Iceland., Trégouët DA; Laboratory of Excellence GENMED (Medical Genomics), Paris, France.; Univ. Bordeaux, INSERM, BPH, Bordeaux, France., Treibel TA; Institute of Cardiovascular Science, University College London, London, UK.; Barts Heart Centre, St Bartholomew's Hospital, London, UK., Ullum H; Statens Serum Institut, Copenhagen, Denmark., Valdes AM; Injury, Recovery and Inflammation Sciences, School of Medicine, University of Nottingham, Nottingham, UK., van Setten J; Department of Cardiology, University Medical Center Utrecht, Utrecht, the Netherlands., van Vugt M; Department of Cardiology, University Medical Center Utrecht, Utrecht, the Netherlands., Veluchamy A; Division of Population Health and Genomics, University of Dundee, Ninewells Hospital and Medical School, Dundee, UK., Verschuren WMM; Department Life Course, Lifestyle and Health, Centre for Prevention, Lifestyle and Health, National Institute for Public Health and the Environment, Bilthoven, the Netherlands.; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands., Villard E; Sorbonne Research Unit on Cardiovascular Disorders, Metabolism and Nutrition, Team Genomics & Pathophysiology of Cardiovascular Diseases, ICAN Institute for Cardiometabolism and Nutrition, Paris, France., Yang Y; Penn Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Asselbergs FW; Institute of Cardiovascular Science, University College London, London, UK.; The National Institute for Health Research University College London Hospitals Biomedical Research Centre, University College London, London, UK.; Department of Cardiology, Amsterdam University Medical Centers, Amsterdam, the Netherlands., Cappola TP; Penn Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Dube MP; Montreal Heart Institute, Montreal Heart Institute, Montreal, Quebec, Canada.; Faculty of Medicine, Université de Montréal, Montreal, Quebec, Canada., Dunn ME; Cardiovascular Research, Regeneron Pharmaceuticals, Tarrytown, NY, USA., Ellinor PT; Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Cardiac Arrhythmia Service and Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA., Hingorani AD; Institute of Cardiovascular Science, University College London, London, UK., Lang CC; Division of Molecular & Clinical Medicine, University of Dundee, Ninewells Hospital and Medical School, Dundee, UK.; Tuanku Muhriz Chair, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia., Samani NJ; Department of Cardiovascular Sciences, University of Leicester and NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK., Shah SH; Department of Medicine, Division of Cardiology, Duke University Medical Center, Durham, NC, USA.; Duke Clinical Research Institute, Durham, NC, USA.; Duke Molecular Physiology Institute, Durham, NC, USA., Smith JG; Department of Cardiology, Clinical Sciences, Lund University and Skåne University Hospital, Lund, Sweden.; Department of Molecular and Clinical Medicine, Institute of Medicine, Gothenburg University and Sahlgrenska University Hospital, Gothenburg, Sweden.; Wallenberg Center for Molecular Medicine and Lund University Diabetes Center, Lund University, Lund, Sweden., Vasan RS; National Heart, Lung, and Blood Institute's and Boston University's Framingham Heart Study, Framingham, MA, USA.; Sections of Cardiology, Preventive Medicine and Epidemiology, Department of Medicine, Boston University Schools of Medicine and Public Health, Boston, MA, USA., O'Regan DP; MRC Laboratory of Medical Sciences, London, UK., Holm H; deCODE genetics/Amgen Inc., Reykjavik, Iceland., Noseda M; National Heart and Lung Institute, Imperial College London, London, UK., Wells Q; Division of Cardiovascular Medicine, Vanderbilt University, Nashville, TN, USA., Ware JS; National Heart and Lung Institute, Imperial College London, London, UK. j.ware@imperial.ac.uk.; MRC Laboratory of Medical Sciences, London, UK. j.ware@imperial.ac.uk.; Royal Brompton & Harefield Hospitals, Guy's and St. Thomas' NHS Foundation Trust, London, UK. j.ware@imperial.ac.uk.; Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA. j.ware@imperial.ac.uk., Lumbers RT; Institute of Health Informatics, University College London, London, UK. t.lumbers@ucl.ac.uk.; Health Data Research UK, University College London, London, UK. t.lumbers@ucl.ac.uk.; British Heart Foundation Data Science Centre, London, UK. t.lumbers@ucl.ac.uk.

Publikováno v: Nature genetics [Nat Genet] 2024 Nov 21. Date of Electronic Publication: 2024 Nov 21.