Výsledky vyhledávání - "Bonaventure T Ngadjui"

Akademický článek

Virtualizing the p-ANAPL library: a step towards drug discovery from African medicinal plants.

Autor: Fidele Ntie-Kang, Pascal Amoa Onguéné, Ghislain W Fotso, Kerstin Andrae-Marobela, Merhatibeb Bezabih, Jean Claude Ndom, Bonaventure T Ngadjui, Abiodun O Ogundaini, Berhanu M Abegaz, Luc Mbaze Meva'a

Publikováno v: PLoS ONE, Vol 9, Iss 3, p e90655 (2014)

BACKGROUND: Natural products play a key role in drug discovery programs, both serving as drugs and as templates for the synthesis of drugs, even though the quantities and availabilities of samples for screening are often limitted. EXPERIMENTAL APPROA

Externí odkaz: https://doaj.org/article/344722ca87b044abb1c15e003ba5155b

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Akademický článek

Cytotoxicity of the methanol extracts and compounds of Brucea antidysenterica (Simaroubaceae) towards multifactorial drug-resistant human cancer cell lines

Autor: Laetitia M. Youmbi, Yves S. D. Makong, Armelle T. Mbaveng, Simplice B. Tankeo, Ghislain W. Fotso, Bruno L. Ndjakou, Jean D. Wansi, Veronique P. Beng, Norbert Sewald, Bonaventure T. Ngadjui, Thomas Efferth, Victor Kuete

Publikováno v: BMC Complementary Medicine and Therapies, Vol 23, Iss 1, Pp 1-14 (2023)

Abstract Background Cancer remains a global health concern and constitutes an important barrier to increasing life expectancy. Malignant cells rapidly develop drug resistance leading to many clinical therapeutic failures. The importance of medicinal

Externí odkaz: https://doaj.org/article/36d620ea789f4352a7d5b3163427eb97

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Akademický článek

Antibacterial and antibiotic-potentiation activity of the constituents from aerial part of Donella welwitshii (Sapotaceae) against multidrug resistant phenotypes

Autor: Michel-Gael F. Guefack, Marcelle O. Ngangoue, Armelle T. Mbaveng, Paul Nayim, Jenifer R. N. Kuete, Carine M. N. Ngaffo, Godloves F. Chi, Bathelemy Ngameni, Bonaventure T. Ngadjui, Victor Kuete

Publikováno v: BMC Complementary Medicine and Therapies, Vol 22, Iss 1, Pp 1-14 (2022)

Abstract Background The rise of multidrug-resistant (MDR) bacteria is a real public health problem worldwide and is responsible for the increase in hospital infections. Donella welwitschii is a liana or shrub belonging to the family Sapotaceae and tr

Externí odkaz: https://doaj.org/article/d7b7e9f6b11145b6acff19a9af8c4ee2

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Akademický článek

Botanicals from the leaves of Acacia sieberiana had better cytotoxic effects than isolated phytochemicals towards MDR cancer cells lines

Autor: Carine M.N. Ngaffo, Rodrigue S.V. Tchangna, Armelle T. Mbaveng, Justin Kamga, Freya M. Harvey, Bonaventure T. Ngadjui, Christian G. Bochet, Victor Kuete

Publikováno v: Heliyon, Vol 6, Iss 11, Pp e05412- (2020)

The efficiency of cancer chemotherapy is seriously hampered by the development of resistance of neoplastic cells to cytotoxic agents. In the present investigation, the cytotoxicity of the dichloromethane-methanol (1:1) extract of Acacia sieberiana (A

Externí odkaz: https://doaj.org/article/f745dc9732944fc1a20f510332b6d9d5

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Phytochemical analysis and antifungal property of Mallotus oppositifolius (Geiseler) Müll.Arg. (Euphorbiaceae)

Autor: Elisabeth Zeuko’o Menkem, Patrick Valere Tsouh Fokou, Fabrice Fekam Boyom, Bonaventure T. Ngadjui, Vincent Ngouana, Valerie Flore Donfack Donkeng, Ghislain W. Fotso

Publikováno v: International Journal of Biological and Chemical Sciences. 15:414-426

The emergence of resistant fungi to available drugs highlights the need for new antifungal drugs. The present study aimed to evaluate the antifungal activity of the isolated compounds, fractions and crude extract from the leaf of Mallotus oppositifol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9b3a22558eb1481e14573c821353d76c
https://doi.org/10.4314/ijbcs.v15i2.4

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Polythosides A and B, two new triterpenoid saponins from the roots of Acacia polyacantha Willd. (Mimosaceae)

Autor: Yoshihito Shiono, Sandrine Carole Tomfeun Nganou, Jun Yoshida, Bonaventure T. Ngadjui, Bernard Dabole, Yoshiaki Ito, Abdou Tchoukoua

Publikováno v: Phytochemistry Letters. 43:190-195

Two new oleanane-type triterpene saponins, named polythosides A and B (1 and 2), together with a known compound, silphioside E (3), were isolated from the roots of Acacia polyacantha. Their structures were elucidated by analysis of 1D and 2D-NMR expe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a92e19e156bed59592586441aa8c7869
https://doi.org/10.1016/j.phytol.2021.04.007

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Antibacterial and antibiotic-potentiation activities of the hydro-ethanolic extract and protoberberine alkaloids from the stem bark of Enantia chlorantha against multidrug-resistant bacteria expressing active efﬂux pumps

Autor: Michel-Gael F. Guefack, Naomie D.M. Messina, Armelle T. Mbaveng, Paul Nayim, Jenifer Reine N. Kuete, Valaire Y. Matieta, Godloves F. Chi, Bonaventure T. Ngadjui, Victor Kuete

Publikováno v: Journal of ethnopharmacology. 296

Enantia chlorantha is traditionally used to treat various ailments including rickettsia fever, cough and wounds, typhoid fever, infective hepatitis, jaundice, and urinary tract infections.To isolate the antibacterial constituents of the hydro-ethanol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::080a8c981153f487d4fc4d7b86ca2ae6
https://pubmed.ncbi.nlm.nih.gov/35788039

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Synthesis and structural characterization of novel O-substituted phenolic and chalcone derivatives with antioxidant activity

Autor: Bathelemy Ngameni, Erdin Dalkılıç, Arif Daştan, Victor Kuete, Musa Erdoğan, Bonaventure T. Ngadjui

Publikováno v: Journal of Chemical Research. 45:159-165

A series of novel 4- O-alkyltriazolylphenolic derivatives is first synthesized with good to excellent yields via the click reaction of 3-methoxy-4- O-propargylbenzaldehyde or 3-allyl-4- O-propargylacetophenone and aromatic azide derivatives. Next, th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9f2fd47b1c9f06c196b175cc8b38ffcb
https://doi.org/10.1177/1747519820932789

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A phenanthridin-6(5H)-one derivative and a lanostane-type triterpene with antibacterial properties from Anonidium mannii (Oliv). Engl. & Diels (Annonaceae)

Autor: Bonaventure T. Ngadjui, Brice E. N. Wamba, Gomotsang Bojase, Marcelle Oliviane Ngangoue, Victor Kuete, Japheth O. Ombito, Pantaleon Ambassa, Ghislain W. Fotso, Bathelemy Ngameni, Godloves Fru Chi

Publikováno v: Natural Product Research. 35:4041-4050

The chemical investigation of Anonidium mannii root extract by column chromatography techniques led to the isolation of eight compounds among which two previously unreported compounds; a lanostane-type triterpene, lanosta-7,9(11),23-triene-3β,15α-d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd5a3b3353d99a800f437d89cdb9f2b9
https://doi.org/10.1080/14786419.2020.1758094

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