Mechanisms of antiviral action and toxicities of ipecac alkaloids: Emetine and dehydroemetine exhibit anti-coronaviral activities at non-cardiotoxic concentrations.

Autor: Sidorenko VS; Department of Pharmacological Sciences, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY 11794, USA., Cohen I; Department of Physiology, Renaissance School of Medicine, Stony Brook University, Stony Brook, New York 11794, USA., Dorjee K; Division of Infectious Diseases, John Hopkins School of Medicine, Baltimore, Maryland 21205, USA., Minetti CA; Department of Chemistry and Chemical Biology, Rutgers - The State University of New Jersey, Piscataway, New Jersey 08854, USA., Remeta DP; Department of Chemistry and Chemical Biology, Rutgers - The State University of New Jersey, Piscataway, New Jersey 08854, USA., Gao J; Department of Physiology, Renaissance School of Medicine, Stony Brook University, Stony Brook, New York 11794, USA., Potapova I; Department of Physiology, Renaissance School of Medicine, Stony Brook University, Stony Brook, New York 11794, USA., Wang HZ; Department of Physiology, Renaissance School of Medicine, Stony Brook University, Stony Brook, New York 11794, USA., Hearing J; Department of Microbiology and Immunology, Renaissance School of Medicine, Stony Brook University, Stony Brook, New York 11794, USA., Yen WY; Department of Microbiology and Immunology, Renaissance School of Medicine, Stony Brook University, Stony Brook, New York 11794, USA., Kim HK; Department of Microbiology and Immunology, Renaissance School of Medicine, Stony Brook University, Stony Brook, New York 11794, USA., Hashimoto K; Department of Pharmacological Sciences, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY 11794, USA., Moriya M; Department of Pharmacological Sciences, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY 11794, USA., Dickman KG; Department of Pharmacological Sciences, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY 11794, USA; Department of Medicine, Renaissance School of Medicine, Stony Brook University, Stony Brook, New York 11794, USA., Yin X; Department of Pharmacological Sciences, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY 11794, USA., Garcia-Diaz M; Department of Pharmacological Sciences, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY 11794, USA., Chennamshetti R; Department of Pharmacological Sciences, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY 11794, USA., Bonala R; Department of Pharmacological Sciences, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY 11794, USA., Johnson F; Department of Pharmacological Sciences, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY 11794, USA; Department of Chemistry, Stony Brook University, Stony Brook, New York 11794, USA., Waldeck AL; Department of Pharmacological Sciences, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY 11794, USA; Department of Pharmacy, Stony Brook University Hospital, Stony Brook, New York 11794, USA., Gupta R; ChemMaster International Inc., Happauge, New York 11788, USA., Li C; Chemistry Service Unit of Shanghai Haoyuan Chemexpress Co., Ltd., Shanghai, PR China 201203., Breslauer KJ; Department of Chemistry and Chemical Biology, Rutgers - The State University of New Jersey, Piscataway, New Jersey 08854, USA; Rutgers Cancer Institute of New Jersey, New Brunswick, NJ 08901, USA., Grollman AP; Department of Pharmacological Sciences, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY 11794, USA; Department of Medicine, Renaissance School of Medicine, Stony Brook University, Stony Brook, New York 11794, USA., Rosenquist TA; Department of Pharmacological Sciences, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY 11794, USA. Electronic address: thomas.rosenquist@stonybrook.edu.

Publikováno v: Virus research [Virus Res] 2024 Mar; Vol. 341, pp. 199322. Date of Electronic Publication: 2024 Jan 19.

Enhanced thermal stability enables human mismatch-specific thymine–DNA glycosylase to catalyse futile DNA repair.

Autor: Manapkyzy, Diana^1,2 (AUTHOR), Joldybayeva, Botagoz^1,2 (AUTHOR), Ishchenko, Alexander A.³ (AUTHOR), Matkarimov, Bakhyt T.⁴ (AUTHOR), Zharkov, Dmitry O.^5,6 (AUTHOR), Taipakova, Sabira^1,2,4 (AUTHOR) sabira.taipakova@gmail.com, Saparbaev, Murat K.³ (AUTHOR) murat.saparbaev@gustaveroussy.fr

Publikováno v: PLoS ONE. 10/18/2024, Vol. 19 Issue 10, p1-32. 32p.

A Multi-Spectroscopic and Molecular Docking Analysis of the Biophysical Interaction between Food Polyphenols, Urolithins, and Human Serum Albumin.

Autor: Zelenović, Nevena¹ (AUTHOR) nevenazelenovic@gmail.com, Ristić, Predrag² (AUTHOR) predrag@chem.bg.ac.rs, Polović, Natalija² (AUTHOR) polovicn@chem.bg.ac.rs, Todorović, Tamara² (AUTHOR) tamarat@chem.bg.ac.rs, Kojadinović, Milica³ (AUTHOR) milica.kojadinovic.imr@gmail.com, Popović, Milica² (AUTHOR) la_bioquimica@chem.bg.ac.rs

Publikováno v: Molecules. Sep2024, Vol. 29 Issue 18, p4474. 23p.

Bioactivation mechanisms of N-hydroxyaristolactams: Nitroreduction metabolites of aristolochic acids.

Autor: Okuno Y; Department of Applied Chemistry and Biochemistry, National Institute of Technology, Wakayama College, 77 Noshima, Nada, Gobo-shi, Wakayama, 644-0023, Japan.; Department of Material Science and Engineering, Material Science and Engineering, Wakayama National College of Technology, Gobo-shi, Wakayama, 644-0023, Japan., Bonala R; Department of Pharmacological Sciences, Stony Brook University, Stony Brook, New York, 11794, USA., Attaluri S; Department of Pharmacological Sciences, Stony Brook University, Stony Brook, New York, 11794, USA., Johnson F; Department of Pharmacological Sciences, Stony Brook University, Stony Brook, New York, 11794, USA.; Department of Chemistry, Stony Brook University, Stony Brook, New York, 11794, USA., Grollman AP; Department of Pharmacological Sciences, Stony Brook University, Stony Brook, New York, 11794, USA.; Department of Medicine, Stony Brook University, Stony Brook, New York, 11794, USA., Sidorenko VS; Department of Pharmacological Sciences, Stony Brook University, Stony Brook, New York, 11794, USA., Oda Y; Institute of Life and Environmental Sciences, Osaka Shin-Ai College, 6-2-28 Tsurumi, Tsurumi-ku, Osaka, 538-0053, Japan.

Publikováno v: Environmental and molecular mutagenesis [Environ Mol Mutagen] 2019 Dec; Vol. 60 (9), pp. 792-806. Date of Electronic Publication: 2019 Aug 16.

Bioactivation of the tobacco carcinogens 4-aminobiphenyl (4-ABP) and 2-amino-9H-pyrido[2,3-b]indole (AαC) in human bladder RT4 cells.

Autor: Bellamri M; Masonic Cancer Center and Department of Medicinal Chemistry, Cancer and Cardiovascular Research Building, University of Minnesota, 2231 6th Street, Minneapolis, MN, 55455, USA., Yao L; Masonic Cancer Center and Department of Medicinal Chemistry, Cancer and Cardiovascular Research Building, University of Minnesota, 2231 6th Street, Minneapolis, MN, 55455, USA., Bonala R; Department of Pharmacological Sciences, Stony Brook University, Stony Brook, NY, 11794, USA., Johnson F; Department of Pharmacological Sciences, Stony Brook University, Stony Brook, NY, 11794, USA.; Department of Chemistry, Stony Brook University, Stony Brook, NY, 11794, USA., Von Weymarn LB; Department of Biochemistry, Molecular Biology and Biophysics and Masonic Cancer Center, University of Minnesota, Minneapolis, MN, 55455, USA., Turesky RJ; Masonic Cancer Center and Department of Medicinal Chemistry, Cancer and Cardiovascular Research Building, University of Minnesota, 2231 6th Street, Minneapolis, MN, 55455, USA. Rturesky@umn.edu.

Publikováno v: Archives of toxicology [Arch Toxicol] 2019 Jul; Vol. 93 (7), pp. 1893-1902. Date of Electronic Publication: 2019 Jun 15.