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Agonist Activation of F-Actin-Mediated Eosinophil Shape Change and Mediator Release Is Dependent on Rac2

Autor: Lian Willetts, Redwan Moqbel, John D. Kim, Paige Lacy, Nives Zimmermann, Bon Lam, Marc E. Rothenberg, Andrea N. Lo, Emily I. MacLean

Publikováno v: International Archives of Allergy and Immunology. 156:137-147

Background: Tissue recruitment and activation of eosinophils contribute to allergic symptoms by causing airway hyperresponsiveness and inflammation. Shape changes and mediator release in eosinophils may be regulated by mammalian Rho-related guanosine

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::259f62ab1a409b28127bb0d7abdf43e1
https://doi.org/10.1159/000322597

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First Reported Case of a Brodie Abscess in the Hand

Autor: Bon Lam, Jennifer Matthews, Jill P. Stone

Publikováno v: Plastic Surgery Case Studies. 3:2513826X1775109

Brodie abscess is an uncommon form of osteomyelitis. Diagnosis can be difficult due to the insidious onset of symptoms and radiographic features that closely resemble more common pathology. The present report describes a patient with a Brodie abscess

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::693df9f817f29807e573a56a1cbaa42a
https://doi.org/10.1177/2513826x17751095

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Abstract LB-166: Cabozantinib (cabo) + abiraterone (abi) combination therapy in castration resistant prostate cancer (CRPC): preclinical evaluation and interim results of an investigator-sponsored phase 1 clinical study

Autor: Xiaodong Wang, Andrew Wick, Philip W. Kantoff, Amanda Fredericks, Christopher Sweeney, Bon Lam, Katherine Zukotynski

Publikováno v: Cancer Research. 73:LB-166

Introduction: Abi (CYP17A1 and lyase inhibitor) and cabo (multi-targeted receptor tyrosine kinase inhibitor including MET and VEGFR2) have complementary mechanisms of action and both have significant single agent activity in CRPC. Cabo decreases evid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9d0e7aee1e9d268d61abda89a253bfcd
https://doi.org/10.1158/1538-7445.am2013-lb-166

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Mutations affecting levels of tetrahydrofolate interconversion enzymes in Saccharomyces cerevisiae

Autor: Keng-Bon Lam, Elizabeth W. Jones

Publikováno v: Molecular and General Genetics MGG. 123:209-218

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::101ad4aabad476e060e918617f90bc2e
https://doi.org/10.1007/bf00271239

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Mutations affecting levels of tetrahydrofolate interconversion enzymes in Saccharomyces cerevisiae. I. Enzyme levels in ade3-41 and ADE15, a dominant adenine auxotroph

Autor: Elizabeth W. Jones, Keng-Bon Lam

Publikováno v: Moleculargeneral genetics : MGG. 123(3)

The ADE15 mutation causes a requirement for adenine. It is dominant to its wild type allele as measured by growth of the heterozygous diploid. The mutation results in altered levels of three tetrahydrofolate interconversion enzymes. The presence of a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9774fcf0612d3e41e9aa90df5dde3b55
https://pubmed.ncbi.nlm.nih.gov/4147243

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