Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Bomina Park"'
Autor:
Nathan R. Jensen, Nathan Lambert-Cheatham, Gabriella D. Hartman, Anbukkarasi Muniyandi, Bomina Park, Kamakshi Sishtla, Timothy W. Corson
Publikováno v:
MethodsX, Vol 9, Iss , Pp 101809- (2022)
Laser-induced choroidal neovascularization (L-CNV) in murine models is a standard method for assessing therapies, genetics, and mechanisms relevant to the blinding eye disease neovascular or “wet” age-related macular degeneration. The ex vivo eva
Externí odkaz:
https://doaj.org/article/639f29d7190e46a5a20f4295d3c85dcb
Autor:
Bomina Park, Sheik Pran Babu Sardar Pasha, Kamakshi L. Sishtla, Gabriella D. Hartman, Xiaoping Qi, Michael E. Boulton, Timothy W. Corson
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 24, p 15595 (2022)
Neovascular or “wet” age-related macular degeneration (nAMD) is a leading cause of blindness among older adults. Choroidal neovascularization (CNV) is a major pathological feature of nAMD, in which abnormal new blood vessel growth from the choroi
Externí odkaz:
https://doaj.org/article/5d54890081f24830bb1ca1c2f5618936
Publikováno v:
STAR Protocols, Vol 2, Iss 2, Pp 100533- (2021)
Summary: Mitochondrial metabolism is a critical mechanism that is deregulated in numerous retinal diseases. Here, we elaborate a protocol to quantify oxygen consumption rate as a measure of mitochondrial respiration directly from mouse retinal tissue
Externí odkaz:
https://doaj.org/article/7db06dd5cc054caf93be94225e64f0e8
Publikováno v:
iScience, Vol 23, Iss 8, Pp 101391- (2020)
Summary: The relationship between heme metabolism and angiogenesis is poorly understood. The final synthesis of heme occurs in mitochondria, where ferrochelatase (FECH) inserts Fe2+ into protoporphyrin IX to produce proto-heme IX. We previously showe
Externí odkaz:
https://doaj.org/article/51f589a3e765499d896aebc14bf2a78d
Autor:
Bomina Park, Timothy W. Corson
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
Ocular diseases cause visual impairment and blindness, imposing a devastating impact on quality of life and a substantial societal economic burden. Many such diseases lack universally effective pharmacotherapies. Therefore, understanding the mediator
Externí odkaz:
https://doaj.org/article/f92bc332a60d4816aa44fc71fe4b33d8
Publikováno v:
Molecules, Vol 25, Iss 15, p 3468 (2020)
Under healthy conditions, the cornea is an avascular structure which allows for transparency and optimal visual acuity. Its avascular nature is maintained by a balance of proangiogenic and antiangiogenic factors. An imbalance of these factors can res
Externí odkaz:
https://doaj.org/article/4384f12bb60c4ad3bd08a614ab0260be
Autor:
Timothy W. Corson, Bomina Park, Stephanie Merrigan, Breandán N. Kennedy, Zaheer Ali, Lasse Jensen
Publikováno v:
Oncotarget. 11:493-509
Aberrant ocular angiogenesis can underpin vision loss in leading causes of blindness, including neovascular age-related macular degeneration and proliferative diabetic retinopathy. Current pharmacological interventions require repeated invasive admin
Autor:
Elizabeth A. Swallow, Bomina Park
Publikováno v:
Academic Medicine. 97:951-952
Publikováno v:
STAR Protocols
STAR Protocols, Vol 2, Iss 2, Pp 100533-(2021)
STAR Protocols, Vol 2, Iss 2, Pp 100533-(2021)
Summary Mitochondrial metabolism is a critical mechanism that is deregulated in numerous retinal diseases. Here, we elaborate a protocol to quantify oxygen consumption rate as a measure of mitochondrial respiration directly from mouse retinal tissue
Autor:
Kamakshi Sishtla, Nathan Lambert-Cheatham, Bit Lee, Duk Hee Han, Jaehui Park, Sheik Pran Babu Sardar Pasha, Sanha Lee, Sangil Kwon, Anbukkarasi Muniyandi, Bomina Park, Noa Odell, Sydney Waller, Il Yeong Park, Soo Jae Lee, Seung-Yong Seo, Timothy W. Corson
Publikováno v:
Cell Chem Biol
Activity of the heme synthesis enzyme ferrochelatase (FECH) is implicated in multiple diseases. In particular, it is a mediator of neovascularization in the eye and thus an appealing therapeutic target for preventing blindness. However, no drug-like