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Heightened NLRP3 inflammasome activation is associated with aging and CMML diseases severity

Autor: Andina, Nicola, de Meuron, Louise, Schnegg-Kaufmann, Annatina Sarah, Ansermet, Camille, Bombaci, Giuseppe, Keller, Nino, Porret, Naomi, Angelillo-Scherrer, Anne, Bonadies, Nicolas, Allam, Ramanjaneyulu

Publikováno v: Andina, Nicola; de Meuron, Louise; Schnegg-Kaufmann, Annatina Sarah; Ansermet, Camille; Bombaci, Giuseppe; Keller, Nino; Porret, Naomi; Angelillo-Scherrer, Anne; Bonadies, Nicolas; Allam, Ramanjaneyulu (31 January 2022). Heightened NLRP3 inflammasome activation is associated with aging and CMML diseases severity (bioRxiv). Cold Spring Harbor Laboratory 10.1101/2022.01.27.477992

Aging causes chronic low-grade inflammation known as inflamm-aging. It is a risk factor for chronic myelomonocytic leukemia (CMML), a hematological malignancy that is most prevalent in older people. Recent studies suggest a critical role for the NLRP

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea8ff91a6423e690c17e6dcdfdf348f3

Publisher Correction: Translation efficiency driven by CNOT3 subunit of the CCR4-NOT complex promotes leukemogenesis.

Autor: Ghashghaei, Maryam, Liu, Yilin, Ettles, James, Bombaci, Giuseppe, Ramkumar, Niveditha, Liu, Zongmin, Escano, Leo, Miko, Sandra Spencer, Kim, Yerin, Waldron, Joseph A., Do, Kim, MacPherson, Kyle, Yuen, Katie A., Taibi, Thilelli, Yue, Marty, Arsalan, Aaremish, Jin, Zhen, Edin, Glenn, Karsan, Aly, Morin, Gregg B.

Publikováno v: Nature Communications; 10/7/2024, Vol. 15 Issue 1, p1-1, 1p

LRR protein RNH1 dampens the inflammasome activation and is associated with adverse clinical outcomes in COVID-19 patients

Autor: Bombaci, Giuseppe, Sarangdhar, Mayuresh Anant, Andina, Nicola, Tardivel, Aubry Bernard Maurice, Chi-Wang Yu, Eric, Mackie, Gillian M., Pugh, Matthew, Ozan, Vedat Burak, Banz, Yara, Spinetti, Thibaud, Hirzel, C��dric, Youd, Esther, Schefold, Joerg C., Taylor, Graham, Gazdhar, Amiq, Bonadies, Nicolas, Angelillo-Scherrer, Anne, Schneider, Pascal, Maslowski, Kendle M., Allam, Ramanjaneyulu

Publikováno v: Bombaci, Giuseppe; Sarangdhar, Mayuresh Anant; Andina, Nicola; Tardivel, Aubry Bernard Maurice; Chi-Wang Yu, Eric; Mackie, Gillian M.; Pugh, Matthew; Ozan, Vedat Burak; Banz, Yara; Spinetti, Thibaud; Hirzel, Cédric; Youd, Esther; Schefold, Joerg C.; Taylor, Graham; Gazdhar, Amiq; Bonadies, Nicolas; Angelillo-Scherrer, Anne; Schneider, Pascal; Maslowski, Kendle M. and Allam, Ramanjaneyulu (26 August 2021). LRR protein RNH1 dampens the inflammasome activation and is associated with adverse clinical outcomes in COVID-19 patients (In Press) (bioRxiv). Cold Spring Harbor Laboratory 10.1101/2021.04.12.438219

Inflammasomes are cytosolic innate immune sensors of pathogen infection and cellular damage that induce caspase-1 mediated inflammation upon activation. Although inflammation is protective, uncontrolled excessive inflammation can cause inflammatory d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3b8f21ecf123d61ff8e5a3f861078bf