Structure-Activity Relationship of Inositol Thiophosphate Analogs as Allosteric Activators of Clostridioides difficile Toxin B.

Autor: Cummer R; Department of Pharmacology and Therapeutics, McGill University, Québec H3G 1Y6, Canada., Grosjean F; Department of Pharmacology and Therapeutics, McGill University, Québec H3G 1Y6, Canada., Bolteau R; Department of Pharmacology and Therapeutics, McGill University, Québec H3G 1Y6, Canada., Vasegh SE; Department of Pharmacology and Therapeutics, McGill University, Québec H3G 1Y6, Canada., Veyron S; Department of Pharmacology and Therapeutics, McGill University, Québec H3G 1Y6, Canada., Keogh L; Department of Pharmacology and Therapeutics, McGill University, Québec H3G 1Y6, Canada., Trempe JF; Department of Pharmacology and Therapeutics, McGill University, Québec H3G 1Y6, Canada., Castagner B; Department of Pharmacology and Therapeutics, McGill University, Québec H3G 1Y6, Canada.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2024 Sep 26; Vol. 67 (18), pp. 16576-16597. Date of Electronic Publication: 2024 Sep 10.

High ligand efficiency quinazoline compounds as novel A 2A adenosine receptor antagonists.

Autor: Bolteau R; Univ. Lille, Inserm, CHU Lille, U1172, LilNCog - Lille Neuroscience & Cognition, F-59000, Lille, France., Duroux R; Univ. Lille, Inserm, CHU Lille, U1172, LilNCog - Lille Neuroscience & Cognition, F-59000, Lille, France., Laversin A; Univ. Lille, Inserm, CHU Lille, U1172, LilNCog - Lille Neuroscience & Cognition, F-59000, Lille, France., Vreulz B; Univ. Lille, Inserm, CHU Lille, U1172, LilNCog - Lille Neuroscience & Cognition, F-59000, Lille, France., Shiriaeva A; Department of Chemistry, University of Southern California, Los Angeles, CA, USA., Stauch B; Bridge Institute, USC Michelson Center for Convergent Biosciences, University of Southern Califorinia, Los Angeles, CA, USA; Department of Chemistry, University of Southern California, Los Angeles, CA, USA., Han GW; Bridge Institute, USC Michelson Center for Convergent Biosciences, University of Southern Califorinia, Los Angeles, CA, USA; Department of Chemistry, University of Southern California, Los Angeles, CA, USA., Cherezov V; Bridge Institute, USC Michelson Center for Convergent Biosciences, University of Southern Califorinia, Los Angeles, CA, USA; Department of Chemistry, University of Southern California, Los Angeles, CA, USA., Renault N; Univ. Lille, Inserm, U995 - LIRIC - Lille Inflammation Research International Center, ICPAL, 3 rue du Professeur Laguesse, BP-83, F-59006, Lille, France., Barczyk A; Univ. Lille, Inserm, U995 - LIRIC - Lille Inflammation Research International Center, ICPAL, 3 rue du Professeur Laguesse, BP-83, F-59006, Lille, France., Ravez S; Univ. Lille, Inserm, CHU Lille, U1172, LilNCog - Lille Neuroscience & Cognition, F-59000, Lille, France., Coevoet M; Univ. Lille, Inserm, CHU Lille, U1172, LilNCog - Lille Neuroscience & Cognition, F-59000, Lille, France., Melnyk P; Univ. Lille, Inserm, CHU Lille, U1172, LilNCog - Lille Neuroscience & Cognition, F-59000, Lille, France., Liberelle M; Univ. Lille, Inserm, CHU Lille, U1172, LilNCog - Lille Neuroscience & Cognition, F-59000, Lille, France. Electronic address: maxime.liberelle@univ-lille.fr., Yous S; Univ. Lille, Inserm, CHU Lille, U1172, LilNCog - Lille Neuroscience & Cognition, F-59000, Lille, France.

Publikováno v: European journal of medicinal chemistry [Eur J Med Chem] 2022 Nov 05; Vol. 241, pp. 114620. Date of Electronic Publication: 2022 Jul 22.

Quinazoline and phthalazine derivatives as novel melatonin receptor ligands analogues of agomelatine.

Autor: Bolteau R; Univ. Lille, Inserm, CHU Lille, UMR-S1172 - JPArc - Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer, F-59000, Lille, France., Descamps F; Univ. Lille, Inserm, CHU Lille, UMR-S1172 - JPArc - Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer, F-59000, Lille, France., Ettaoussi M; Univ. Lille, Inserm, CHU Lille, UMR-S1172 - JPArc - Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer, F-59000, Lille, France. Electronic address: m.ettaoussi@yahoo.fr., Caignard DH; PEX Biotechnologie Chimie & Biologie, Institut de Recherches Servier, 78290, Croissy sur Seine, France; Institut de Recherches Internationales Servier, 92150, Suresnes, France., Delagrange P; PEX Biotechnologie Chimie & Biologie, Institut de Recherches Servier, 78290, Croissy sur Seine, France., Melnyk P; Univ. Lille, Inserm, CHU Lille, UMR-S1172 - JPArc - Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer, F-59000, Lille, France., Yous S; Univ. Lille, Inserm, CHU Lille, UMR-S1172 - JPArc - Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer, F-59000, Lille, France. Electronic address: said.yous@univ-lille2.fr.

Publikováno v: European journal of medicinal chemistry [Eur J Med Chem] 2020 Mar 01; Vol. 189, pp. 112078. Date of Electronic Publication: 2020 Jan 22.

Selenylated Imidazo [1,2- a ]pyridine Induces Apoptosis and Oxidative Stress in 2D and 3D Models of Colon Cancer Cells.

Autor: Gomes, Giovana Bicudo¹ (AUTHOR) giovana.bicudo@ufms.br, Zubieta, Claudia Stutz¹ (AUTHOR) claudia.stutz@gmail.com, Guilhermi, Jhefferson dos Santos² (AUTHOR) jheffersonguilhermi@discente.ufg.br, Toffoli-Kadri, Mônica Cristina¹ (AUTHOR) monica.kadri@ufms.br, Beatriz, Adilson³ (AUTHOR) adilson.beatriz@ufms.br, Rafique, Jamal^2,3 (AUTHOR) jamal.rafique@ufms.br, Parisotto, Eduardo Benedetti¹ (AUTHOR) eduardo.parisotto@ufms.br, Saba, Sumbal² (AUTHOR) sumbalsaba@ufg.br, Perdomo, Renata Trentin¹ (AUTHOR) sumbalsaba@ufg.br

Publikováno v: Pharmaceuticals (14248247). Jun2023, Vol. 16 Issue 6, p814. 15p.

Recent developments in the green synthesis of biologically relevant cinnolines and phthalazines.

Autor: Mekheimer, Ramadan Ahmed, Abd-Elmonem, Mohamed, Abou Elsebaa, Mohamed, Nazmy, Maiiada Hassan, Sadek, Kamal Usef

Publikováno v: Physical Sciences Reviews; Oct2023, Vol. 8 Issue 10, p3183-3267, 85p