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Modified C-type natriuretic peptide normalizes tumor vasculature, reinvigorates antitumor immunity, and improves solid tumor therapies.

Autor: Lu Z; Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Verginadis I; Department of Radiation Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Kumazoe M; Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, Fukuoka 819-0395, Japan., Castillo GM; PharmaIN Corp., Bothell, WA 98011, USA., Yao Y; PharmaIN Corp., Bothell, WA 98011, USA., Guerra RE; PharmaIN Corp., Bothell, WA 98011, USA., Bicher S; Department of Radiation Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., You M; Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., McClung G; Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Qiu R; Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Xiao Z; Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Miao Z; Department of Biology, School of Arts & Sciences, University of Pennsylvania, Philadelphia, PA 19104, USA., George SS; Institute for Biomedical Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Beiting DP; Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Nojiri T; Department of General Thoracic Surgery, Higashiosaka City Medical Center, Higashiosaka 578-8588, Japan., Tanaka Y; Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, Fukuoka 819-0395, Japan., Fujimura Y; Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, Fukuoka 819-0395, Japan., Onda H; Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, Fukuoka 819-0395, Japan., Hatakeyama Y; Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, Fukuoka 819-0395, Japan., Nishimoto-Ashfield A; PharmaIN Corp., Bothell, WA 98011, USA., Bykova K; PharmaIN Corp., Bothell, WA 98011, USA., Guo W; Department of Biology, School of Arts & Sciences, University of Pennsylvania, Philadelphia, PA 19104, USA., Fan Y; Department of Radiation Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Buynov NM; PharmaIN Corp., Bothell, WA 98011, USA., Diehl JA; Department of Biochemistry, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA., Stanger BZ; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Tachibana H; Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, Fukuoka 819-0395, Japan., Gade TP; Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Puré E; Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Koumenis C; Department of Radiation Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Bolotin EM; PharmaIN Corp., Bothell, WA 98011, USA., Fuchs SY; Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

Publikováno v: Science translational medicine [Sci Transl Med] 2024 Aug 21; Vol. 16 (761), pp. eadn0904. Date of Electronic Publication: 2024 Aug 21.

Omeprazole and PGC-formulated heparin binding epidermal growth factor normalizes fasting blood glucose and suppresses insulitis in multiple low dose streptozotocin diabetes model.

Autor: Castillo GM; PharmaIN Corporation, 19805 North Creek Parkway, Suite 200, Bothell, Washington, 98011, USA, gcastillo@pharmain.com., Nishimoto-Ashfield A, Banerjee AA, Landolfi JA, Lyubimov AV, Bolotin EM

Publikováno v: Pharmaceutical research [Pharm Res] 2013 Nov; Vol. 30 (11), pp. 2843-54. Date of Electronic Publication: 2013 Jun 21.