Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Bolormaa Baljinnyam"'
Autor:
Wenjing Yan, Yongwang Zhong, Xin Hu, Tuan Xu, Yinghua Zhang, Stephen Kales, Yanyan Qu, Daniel C. Talley, Bolormaa Baljinnyam, Christopher A. LeClair, Anton Simeonov, Brian M. Polster, Ruili Huang, Yihong Ye, Ganesha Rai, Mark J. Henderson, Dingyin Tao, Shengyun Fang
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract UBA1 is the primary E1 ubiquitin-activating enzyme responsible for generation of activated ubiquitin required for ubiquitination, a process that regulates stability and function of numerous proteins. Decreased or insufficient ubiquitination
Externí odkaz:
https://doaj.org/article/f3f674c5f7b14cfbb5a8b35c4adc9a3f
Autor:
Shelby D. Foor, Kalvis Brangulis, Anil K. Shakya, Vipin S. Rana, Sandhya Bista, Chrysoula Kitsou, Michael Ronzetti, Adit B. Alreja, Sara B. Linden, Amanda S. Altieri, Bolormaa Baljinnyam, Inara Akopjana, Daniel C. Nelson, Anton Simeonov, Osnat Herzberg, Melissa J. Caimano, Utpal Pal
Publikováno v:
mBio, Vol 14, Iss 5 (2023)
ABSTRACT Borrelia burgdorferi, the pathogen of Lyme disease, encodes many conserved proteins of unknown structure or function, including ones that serve essential roles in microbial infectivity. One such protein is BB0238, which folds into a two-doma
Externí odkaz:
https://doaj.org/article/41e800ac2ac0401a9b693dae646e6521
Autor:
Samar Sayedyahossein, Jessica Smith, Elena Barnaeva, Zhigang Li, Jun Choe, Michael Ronzetti, Christopher Dextras, Xin Hu, Juan Marugan, Noel Southall, Bolormaa Baljinnyam, Louise Thines, Andy D. Tran, Marc Ferrer, David B. Sacks
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-15 (2022)
Abstract The small GTPase Cdc42 is an integral component of the cytoskeleton, and its dysregulation leads to pathophysiological conditions, such as cancer. Binding of Cdc42 to the scaffold protein IQGAP1 stabilizes Cdc42 in its active form. The inter
Externí odkaz:
https://doaj.org/article/1a21390492ac417fa1c9c755b05598aa
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Externí odkaz:
https://doaj.org/article/0cf2d44e6d4247f28a0f68a09f5b30fe
Autor:
Michael H. Ronzetti, Bolormaa Baljinnyam, Zina Itkin, Sankalp Jain, Ganesha Rai, Alexey V. Zakharov, Utpal Pal, Anton Simeonov
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Differential scanning fluorimetry is a rapid and economical biophysical technique used to monitor perturbations to protein structure during a thermal gradient, most often by detecting protein unfolding events through an environment-sensitive fluoroph
Externí odkaz:
https://doaj.org/article/8a9e5288eb2147ec8735b9b744e9c86d
Autor:
Kelly A Manthei, Shyh-Ming Yang, Bolormaa Baljinnyam, Louise Chang, Alisa Glukhova, Wenmin Yuan, Lita A Freeman, David J Maloney, Anna Schwendeman, Alan T Remaley, Ajit Jadhav, John JG Tesmer
Publikováno v:
eLife, Vol 7 (2018)
Lecithin:cholesterol acyltransferase (LCAT) and LCAT-activating compounds are being investigated as treatments for coronary heart disease (CHD) and familial LCAT deficiency (FLD). Herein we report the crystal structure of human LCAT in complex with a
Externí odkaz:
https://doaj.org/article/e39ef85950bb4a8db30d83b97e4ee9fa
Publikováno v:
PLoS ONE, Vol 7, Iss 1, p e29455 (2012)
R-spondins (Rspos) comprise a family of four secreted proteins that have important roles in cell proliferation, cell fate determination and organogenesis. Rspos typically exert their effects by potentiating the Wnt/β-catenin signaling pathway. To sy
Externí odkaz:
https://doaj.org/article/faf4cc5649524d3cad2f338e973e3bc9
Autor:
Kevin J. Frankowski, Samarjit Patnaik, Chen Wang, Noel Southall, Dipannita Dutta, Soumitta De, Dandan Li, Christopher Dextras, Yi-Han Lin, Marthe Bryant-Connah, Danielle Davis, Feijun Wang, Leah M. Wachsmuth, Pranav Shah, Jordan Williams, Md Kabir, Edward Zhu, Bolormaa Baljinnyam, Amy Wang, Xin Xu, John Norton, Marc Ferrer, Steve Titus, Anton Simeonov, Wei Zheng, Lesley A. Mathews Griner, Ajit Jadhav, Jeffrey Aubé, Mark J. Henderson, Udo Rudloff, Frank J. Schoenen, Sui Huang, Juan J. Marugan
Publikováno v:
J Med Chem
The perinucleolar compartment (PNC) is a dynamic subnuclear body found at the periphery of the nucleolus. The PNC is enriched with RNA transcripts and RNA-binding proteins, reflecting different states of genome organization. PNC prevalence positively
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77cb0efba8b4e86b0d112961571f1a63
https://doi.org/10.1021/acs.jmedchem.2c00204
https://doi.org/10.1021/acs.jmedchem.2c00204
Autor:
Vipin S. Rana, Chrysoula Kitsou, Shraboni Dutta, Michael H. Ronzetti, Min Zhang, Quentin Bernard, Alexis A. Smith, Julen Tomás-Cortázar, Xiuli Yang, Ming-Jie Wu, Oleksandra Kepple, Weizhong Li, Jennifer E. Dwyer, Jaqueline Matias, Bolormaa Baljinnyam, Jonathan D. Oliver, Nallakkandi Rajeevan, Joao H F Pedra, Sukanya Narasimhan, Yan Wang, Ulrike Munderloh, Erol Fikrig, Anton Simeonov, Juan Anguita, Utpal Pal
Publikováno v:
Science. 379
Ancestral signaling pathways serve critical roles in metazoan development, physiology, and immunity. We report an evolutionary interspecies communication pathway involving a central Ixodes scapularis tick receptor termed Dome1, which acquired a mamma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cdb3c00cd79e58462333434ad827df7e
https://doi.org/10.1126/science.abl3837
https://doi.org/10.1126/science.abl3837
Autor:
Wei Zheng, Jun Choe, Ganesha Rai, Catherine Z. Chen, Alexey V. Zakharov, Matthew D. Hall, Miao Xu, Bolormaa Baljinnyam, Sankalp Jain, Daniel C. Talley, Quinlin M Hanson, Wei Zhu, Min Shen, Xin Hu, Anton Simeonov
Publikováno v:
ACS Pharmacology & Translational Science. 4:1675-1688
The National Center for Advancing Translational Sciences (NCATS) has been actively generating SARS-CoV-2 high-throughput screening data and disseminates it through the OpenData Portal (https://opendata.ncats.nih.gov/covid19/). Here, we provide a hybr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::de4193f0567c7e2ad60a071f22dd1a9d
https://doi.org/10.1021/acsptsci.1c00176
https://doi.org/10.1021/acsptsci.1c00176