Influence of age and co-medication on dolutegravir glucuronidation in paediatric patients.

Autor: Jacobs TG; Department of Pharmacy, Research Institute for Medical Innovation, Radboud University Medical Center, Nijmegen, The Netherlands., Waalewijn H; Department of Pharmacy, Research Institute for Medical Innovation, Radboud University Medical Center, Nijmegen, The Netherlands.; Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa., Houlden L; Medical Research Council Clinical Trials Unit, University College London, London, UK., Bollen PDJ; Department of Pharmacy, Research Institute for Medical Innovation, Radboud University Medical Center, Nijmegen, The Netherlands.; Hospital Gelderse Vallei, Ede, The Netherlands., Nanduudu A; Joint Clinical Research Centre, Kampala, Uganda., Nambi E; Joint Clinical Research Centre, Kampala, Uganda., Cassim H; Perinatal HIV Research Unit, University of the Witwatersrand, Johannesburg, South Africa., Lugemwa A; Joint Clinical Research Centre, Mbarara, Uganda., Makumbi S; Joint Clinical Research Centre, Mbarara, Uganda., Monkiewicz LN; Medical Research Council Clinical Trials Unit, University College London, London, UK., Shakeshaft C; Medical Research Council Clinical Trials Unit, University College London, London, UK., Bamford A; Medical Research Council Clinical Trials Unit, University College London, London, UK., Archary M; Durban International Clinical Research Site, Durban, South Africa., Musuro G; University of Zimbabwe Clinical Research Centre, Harare, Zimbabwe., Chidziva E; University of Zimbabwe Clinical Research Centre, Harare, Zimbabwe., Mujuru HA; University of Zimbabwe Clinical Research Centre, Harare, Zimbabwe., Bwakura-Dangarembizi M; University of Zimbabwe Clinical Research Centre, Harare, Zimbabwe., Chabala C; Department of Paediatrics and Child Health, School of Medicine, University of Zambia, Lusaka, Zambia.; Children's Hospital, University Teaching Hospitals, Lusaka, Zambia., Turkova A; Medical Research Council Clinical Trials Unit, University College London, London, UK., Gibb DM; Medical Research Council Clinical Trials Unit, University College London, London, UK., Cotton MF; Family Centre for Research with Ubuntu, Stellenbosch University, Cape Town, South Africa., Aarnoutse R; Department of Pharmacy, Research Institute for Medical Innovation, Radboud University Medical Center, Nijmegen, The Netherlands., Burger DM; Department of Pharmacy, Research Institute for Medical Innovation, Radboud University Medical Center, Nijmegen, The Netherlands., Colbers A; Department of Pharmacy, Research Institute for Medical Innovation, Radboud University Medical Center, Nijmegen, The Netherlands.

Publikováno v: British journal of clinical pharmacology [Br J Clin Pharmacol] 2024 Nov; Vol. 90 (11), pp. 2947-2952. Date of Electronic Publication: 2024 Sep 03.

The dolutegravir/valproic acid drug-drug interaction is primarily based on protein displacement.

Autor: Bollen PDJ; Department of Pharmacy, Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, The Netherlands., Prins HAB; Department of Medical Microbiology and Infectious Diseases, Erasmus Medical Center, Rotterdam, The Netherlands., Colbers A; Department of Pharmacy, Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, The Netherlands., Velthoven-Graafland K; Department of Pharmacy, Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, The Netherlands., Rijnders BJA; Department of Medical Microbiology and Infectious Diseases, Erasmus Medical Center, Rotterdam, The Netherlands., de Vries-Sluijs TEMS; Department of Medical Microbiology and Infectious Diseases, Erasmus Medical Center, Rotterdam, The Netherlands., van Nood E; Department of Medical Microbiology and Infectious Diseases, Erasmus Medical Center, Rotterdam, The Netherlands., Nouwen J; Department of Medical Microbiology and Infectious Diseases, Erasmus Medical Center, Rotterdam, The Netherlands., Bax H; Department of Medical Microbiology and Infectious Diseases, Erasmus Medical Center, Rotterdam, The Netherlands., de Mendonca Melo M; Department of Medical Microbiology and Infectious Diseases, Erasmus Medical Center, Rotterdam, The Netherlands., Verbon A; Department of Medical Microbiology and Infectious Diseases, Erasmus Medical Center, Rotterdam, The Netherlands., Burger DM; Department of Pharmacy, Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, The Netherlands., Rokx C; Department of Medical Microbiology and Infectious Diseases, Erasmus Medical Center, Rotterdam, The Netherlands.

Publikováno v: The Journal of antimicrobial chemotherapy [J Antimicrob Chemother] 2021 Apr 13; Vol. 76 (5), pp. 1273-1276.

Development and validation of an UPLC-MS/MS bioanalytical method for simultaneous quantification of the antiretroviral drugs dolutegravir, elvitegravir, raltegravir, nevirapine and etravirine in human plasma.

Autor: Bollen PDJ; Department of Pharmacy, Radboud Institute for Health Sciences (RIHS), Radboud University Medical Center, Nijmegen, the Netherlands. Electronic address: Pauline.bollen@radboudumc.nl., de Graaff-Teulen MJA; Department of Pharmacy, Radboud Institute for Health Sciences (RIHS), Radboud University Medical Center, Nijmegen, the Netherlands., Schalkwijk S; Department of Pharmacy, Radboud Institute for Health Sciences (RIHS), Radboud University Medical Center, Nijmegen, the Netherlands., van Erp NP; Department of Pharmacy, Radboud Institute for Health Sciences (RIHS), Radboud University Medical Center, Nijmegen, the Netherlands., Burger DM; Department of Pharmacy, Radboud Institute for Health Sciences (RIHS), Radboud University Medical Center, Nijmegen, the Netherlands.

Publikováno v: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences [J Chromatogr B Analyt Technol Biomed Life Sci] 2019 Jan 15; Vol. 1105, pp. 76-84. Date of Electronic Publication: 2018 Dec 10.