Influence of age and co-medication on dolutegravir glucuronidation in paediatric patients.

Autor: Jacobs TG; Department of Pharmacy, Research Institute for Medical Innovation, Radboud University Medical Center, Nijmegen, The Netherlands., Waalewijn H; Department of Pharmacy, Research Institute for Medical Innovation, Radboud University Medical Center, Nijmegen, The Netherlands.; Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa., Houlden L; Medical Research Council Clinical Trials Unit, University College London, London, UK., Bollen PDJ; Department of Pharmacy, Research Institute for Medical Innovation, Radboud University Medical Center, Nijmegen, The Netherlands.; Hospital Gelderse Vallei, Ede, The Netherlands., Nanduudu A; Joint Clinical Research Centre, Kampala, Uganda., Nambi E; Joint Clinical Research Centre, Kampala, Uganda., Cassim H; Perinatal HIV Research Unit, University of the Witwatersrand, Johannesburg, South Africa., Lugemwa A; Joint Clinical Research Centre, Mbarara, Uganda., Makumbi S; Joint Clinical Research Centre, Mbarara, Uganda., Monkiewicz LN; Medical Research Council Clinical Trials Unit, University College London, London, UK., Shakeshaft C; Medical Research Council Clinical Trials Unit, University College London, London, UK., Bamford A; Medical Research Council Clinical Trials Unit, University College London, London, UK., Archary M; Durban International Clinical Research Site, Durban, South Africa., Musuro G; University of Zimbabwe Clinical Research Centre, Harare, Zimbabwe., Chidziva E; University of Zimbabwe Clinical Research Centre, Harare, Zimbabwe., Mujuru HA; University of Zimbabwe Clinical Research Centre, Harare, Zimbabwe., Bwakura-Dangarembizi M; University of Zimbabwe Clinical Research Centre, Harare, Zimbabwe., Chabala C; Department of Paediatrics and Child Health, School of Medicine, University of Zambia, Lusaka, Zambia.; Children's Hospital, University Teaching Hospitals, Lusaka, Zambia., Turkova A; Medical Research Council Clinical Trials Unit, University College London, London, UK., Gibb DM; Medical Research Council Clinical Trials Unit, University College London, London, UK., Cotton MF; Family Centre for Research with Ubuntu, Stellenbosch University, Cape Town, South Africa., Aarnoutse R; Department of Pharmacy, Research Institute for Medical Innovation, Radboud University Medical Center, Nijmegen, The Netherlands., Burger DM; Department of Pharmacy, Research Institute for Medical Innovation, Radboud University Medical Center, Nijmegen, The Netherlands., Colbers A; Department of Pharmacy, Research Institute for Medical Innovation, Radboud University Medical Center, Nijmegen, The Netherlands.

Publikováno v: British journal of clinical pharmacology [Br J Clin Pharmacol] 2024 Nov; Vol. 90 (11), pp. 2947-2952. Date of Electronic Publication: 2024 Sep 03.

Dolutegravir dosing for children with HIV weighing less than 20 kg: pharmacokinetic and safety substudies nested in the open-label, multicentre, randomised, non-inferiority ODYSSEY trial.

Autor: Waalewijn H; Department of Pharmacy, Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, Netherlands., Chan MK; Medical Research Council Clinical Trials Unit at University College London, University College London, London, UK., Bollen PDJ; Department of Pharmacy, Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, Netherlands., Mujuru HA; University of Zimbabwe Clinical Research Centre, Harare, Zimbabwe., Makumbi S; Joint Clinical Research Centre, Mbarara, Uganda., Kekitiinwa AR; Baylor College of Medicine Children's Foundation, Kampala, Uganda., Kaudha E; Joint Clinical Research Centre, Kampala, Uganda., Sarfati T; Medical Research Council Clinical Trials Unit at University College London, University College London, London, UK., Musoro G; University of Zimbabwe Clinical Research Centre, Harare, Zimbabwe., Nanduudu A; Joint Clinical Research Centre, Kampala, Uganda., Lugemwa A; Joint Clinical Research Centre, Mbarara, Uganda., Amuge P; Baylor College of Medicine Children's Foundation, Kampala, Uganda., Moore CL; Medical Research Council Clinical Trials Unit at University College London, University College London, London, UK., Rojo P; University Hospital October 12, Madrid, Spain., Giaquinto C; Department for Woman's and Child's Health, University of Padova, Padova, Italy., Colbers A; Department of Pharmacy, Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, Netherlands. Electronic address: angela.colbers@radboudumc.nl., Gibb DM; Medical Research Council Clinical Trials Unit at University College London, University College London, London, UK., Ford D; Medical Research Council Clinical Trials Unit at University College London, University College London, London, UK., Turkova A; Medical Research Council Clinical Trials Unit at University College London, University College London, London, UK., Burger DM; Department of Pharmacy, Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, Netherlands.

Publikováno v: The lancet. HIV [Lancet HIV] 2022 May; Vol. 9 (5), pp. e341-e352. Date of Electronic Publication: 2022 Feb 18.

Simplified dolutegravir dosing for children with HIV weighing 20 kg or more: pharmacokinetic and safety substudies of the multicentre, randomised ODYSSEY trial.

Autor: Bollen PDJ; Department of Pharmacy, Radboud Institute for Health Sciences, Radboud university medical center, Nijmegen, Netherlands., Moore CL; Medical Research Council Clinical Trials Unit, University College London, London, UK., Mujuru HA; University of Zimbabwe Clinical Research Centre, Harare, Zimbabwe., Makumbi S; Joint Clinical Research Centre, Mbarara, Uganda., Kekitiinwa AR; Baylor College of Medicine Children's Foundation, Kampala, Uganda., Kaudha E; Joint Clinical Research Centre, Kampala, Uganda., Parker A; Medical Research Council Clinical Trials Unit, University College London, London, UK., Musoro G; University of Zimbabwe Clinical Research Centre, Harare, Zimbabwe., Nanduudu A; Joint Clinical Research Centre, Kampala, Uganda., Lugemwa A; Joint Clinical Research Centre, Mbarara, Uganda., Amuge P; Baylor College of Medicine Children's Foundation, Kampala, Uganda., Hakim JG; University of Zimbabwe Clinical Research Centre, Harare, Zimbabwe., Rojo P; Hospital 12 de Octubre, Madrid, Spain., Giaquinto C; University of Padova, Padova, Italy., Colbers A; Department of Pharmacy, Radboud Institute for Health Sciences, Radboud university medical center, Nijmegen, Netherlands. Electronic address: angela.colbers@radboudumc.nl., Gibb DM; Medical Research Council Clinical Trials Unit, University College London, London, UK., Ford D; Medical Research Council Clinical Trials Unit, University College London, London, UK., Turkova A; Medical Research Council Clinical Trials Unit, University College London, London, UK., Burger DM; Department of Pharmacy, Radboud Institute for Health Sciences, Radboud university medical center, Nijmegen, Netherlands.

Publikováno v: The lancet. HIV [Lancet HIV] 2020 Aug; Vol. 7 (8), pp. e533-e544.

Development and validation of an UPLC-MS/MS bioanalytical method for simultaneous quantification of the antiretroviral drugs dolutegravir, elvitegravir, raltegravir, nevirapine and etravirine in human plasma.

Autor: Bollen PDJ; Department of Pharmacy, Radboud Institute for Health Sciences (RIHS), Radboud University Medical Center, Nijmegen, the Netherlands. Electronic address: Pauline.bollen@radboudumc.nl., de Graaff-Teulen MJA; Department of Pharmacy, Radboud Institute for Health Sciences (RIHS), Radboud University Medical Center, Nijmegen, the Netherlands., Schalkwijk S; Department of Pharmacy, Radboud Institute for Health Sciences (RIHS), Radboud University Medical Center, Nijmegen, the Netherlands., van Erp NP; Department of Pharmacy, Radboud Institute for Health Sciences (RIHS), Radboud University Medical Center, Nijmegen, the Netherlands., Burger DM; Department of Pharmacy, Radboud Institute for Health Sciences (RIHS), Radboud University Medical Center, Nijmegen, the Netherlands.

Publikováno v: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences [J Chromatogr B Analyt Technol Biomed Life Sci] 2019 Jan 15; Vol. 1105, pp. 76-84. Date of Electronic Publication: 2018 Dec 10.

Pharmacokinetics of Generic Pediatric Dolutegravir Dispersible Tablet in Thai Young Children Living With HIV Weighing Below Twenty Kilograms.

Autor: Rungsapphaiboon, Athiporn, Wacharachaisurapol, Noppadol, Anugulruengkitt, Suvaporn, Sirikutt, Pugpen, Tawan, Monta, Saisaengjan, Chutima, Yossawadee Na Nakorn, Paiboon, Nantika, Songtaweesin, Wipaporn Natalie, Tawon, Yardpiroon, Cressey, Tim R., Puthanakit, Thanyawee, Phasomsap, Chayapa

Publikováno v: Pediatric Infectious Disease Journal; Aug2024, Vol. 43 Issue 8, p789-794, 6p