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Improvement of dissolution of poorly soluble drugs by solid deposition on a super disintegrant .2. The choice of super disintegrants and effect of granulation

Autor: Bolhuis, GK, Zuurman, K, teWierik, GHP

Publikováno v: European Journal of Pharmaceutical Sciences, 5(2), 63-69. ELSEVIER SCIENCE BV

It is demonstrated that the dissolution from capsules and tablets of poorly soluble, hydrophobic drugs can be strongly improved by solid deposition of the drug upon hydrophilic, strongly swelling carriers like the super disintegrants sodium starch gl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::47f7156766c1a218abf5d356699ae21c
https://research.rug.nl/en/publications/37ff969c-b319-414f-bb49-5fd35b59f0ad

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The effect of viscoelasticity and tabletting speed on consolidation and relaxation of a viscoelastic material

Autor: Maarschalk, KV, Vromans, H, Bolhuis, GK, Lerk, CF

Publikováno v: European Journal of Pharmaceutics and Biopharmaceutics, 42(1), 49-55. ELSEVIER SCIENCE BV

This paper evalutes the applicability of Dynamic Mechanical Analysis (DMA) as a tool to explain consolidation and relaxation behaviour of a viscoelastic powder compressed at different speeds. From the DMA-data it is concluded that the material become

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::4f8411d34b36fb2894bc68df90978a73
https://research.rug.nl/en/publications/85728e54-7481-41db-8009-802038bd3474

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EFFECT OF BINDER ON THE RELATIONSHIP BETWEEN BULK-DENSITY AND COMPACTIBILITY OF LACTOSE GRANULATIONS

Autor: ZUURMAN, K, BOLHUIS, GK, VROMANS, H

Publikováno v: International Journal of Pharmaceutics, 119(1), 65-69. Elsevier Bedrijfsinformatie b.v.

The effect of a binder on the relationship between the bulk density and compactibility of lactose granulations was studied by comparing binderless granules with granules containing hydroxypropylcellulose. Granulations were prepared from different gra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::5d6fdb4c5dc0160e30860656262df703
https://research.rug.nl/en/publications/69e5356a-54d4-4488-beea-782bef216e18

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THE RELATIONSHIP BETWEEN BULK-DENSITY AND COMPACTIBILITY OF LACTOSE GRANULATIONS

Autor: ZUURMAN, K, RIEPMA, KA, BOLHUIS, GK, VROMANS, H, LERK, CF

Publikováno v: International Journal of Pharmaceutics, 102(1-3), 1-9. Elsevier Bedrijfsinformatie b.v.

The relationship between the bulk density and the compactibility of lactose granulations was studied. The granulations were prepared from different alpha-lactose monohydrate and roller dried beta-lactose powders by wet granulation, using different te

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::eebb74888c718a250f099a751f1d1deb
https://research.rug.nl/en/publications/718209da-0c7c-4779-8a37-78d441b06d04

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CONSOLIDATION AND COMPACTION OF POWDER MIXTURES .3. BINARY-MIXTURES OF DIFFERENT PARTICLE-SIZE FRACTIONS OF DIFFERENT TYPES OF CRYSTALLINE LACTOSE

Autor: RIEPMA, KA, ZUURMAN, K, BOLHUIS, GK, DEBOER, AH, LERK, CF

Publikováno v: International Journal of Pharmaceutics, 85(1-3), 121-128. Elsevier Bedrijfsinformatie b.v.

Tablets were compacted from a coarse fraction (250-315 mum), a fine fraction (32-45 mum) and from binary blends of a coarse and a fine fraction of different types of crystalline lactose. The results showed differences in consolidation and compaction

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::74d5fbce3283111d1be3b9ab1602613b
https://research.rug.nl/en/publications/b6975674-0803-449a-bc73-847ffbb49c53

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CONSOLIDATION AND COMPACTION OF POWDER MIXTURES .2. BINARY-MIXTURES OF DIFFERENT PARTICLE-SIZE FRACTIONS OF ALPHA-LACTOSE MONOHYDRATE

Autor: RIEPMA, KA, VEENSTRA, J, DEBOER, AH, BOLHUIS, GK, ZUURMAN, K, LERK, CF, VROMANS, H

Publikováno v: International Journal of Pharmaceutics, 76(1-2), 9-15. Elsevier Bedrijfsinformatie b.v.

Binary mixtures of different particle size fractions of alpha-lactose monohydrate were compacted into tablets. The results showed decreased crushing strengths and decreased internal specific surface areas of the tablets as compared with the values ca

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::dad15d30400ae121db84f895eeb720ec
https://research.rug.nl/en/publications/5068dbd8-5de9-407d-b9e5-ca52abd5c77e

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CONSOLIDATION AND COMPACTION OF POWDER MIXTURES .1. BINARY-MIXTURES OF SAME PARTICLE-SIZE FRACTIONS OF DIFFERENT TYPES OF CRYSTALLINE LACTOSE

Autor: RIEPMA, KA, LERK, CF, DEBOER, AH, BOLHUIS, GK, KUSSENDRAGER, KD

Publikováno v: International Journal of Pharmaceutics, 66(1-3), 47-52. Elsevier Bedrijfsinformatie b.v.

Binary powder mixtures of four different types of crystalline lactose: alpha-lactose monohydrate, anhydrous alpha-lactose, roller-dried beta-lactose and crystalline beta-lactose, were compressed into tablets. The results showed a proportional interco

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::cb97f5f45b2fd6ffc80787458544506a
https://research.rug.nl/en/publications/7fb5e971-845e-4ddb-aedb-f803370fa073

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