The transcriptional landscape of Shh medulloblastoma

Autor: Patryk Skowron, Hamza Farooq, Florence M. G. Cavalli, A. Sorana Morrissy, Michelle Ly, Liam D. Hendrikse, Evan Y. Wang, Haig Djambazian, Helen Zhu, Karen L. Mungall, Quang M. Trinh, Tina Zheng, Shizhong Dai, Ana S. Guerreiro Stucklin, Maria C. Vladoiu, Vernon Fong, Borja L. Holgado, Carolina Nor, Xiaochong Wu, Diala Abd-Rabbo, Pierre Bérubé, Yu Chang Wang, Betty Luu, Raul A. Suarez, Avesta Rastan, Aaron H. Gillmor, John J. Y. Lee, Xiao Yun Zhang, Craig Daniels, Peter Dirks, David Malkin, Eric Bouffet, Uri Tabori, James Loukides, François P. Doz, Franck Bourdeaut, Olivier O. Delattre, Julien Masliah-Planchon, Olivier Ayrault, Seung-Ki Kim, David Meyronet, Wieslawa A. Grajkowska, Carlos G. Carlotti, Carmen de Torres, Jaume Mora, Charles G. Eberhart, Erwin G. Van Meir, Toshihiro Kumabe, Pim J. French, Johan M. Kros, Nada Jabado, Boleslaw Lach, Ian F. Pollack, Ronald L. Hamilton, Amulya A. Nageswara Rao, Caterina Giannini, James M. Olson, László Bognár, Almos Klekner, Karel Zitterbart, Joanna J. Phillips, Reid C. Thompson, Michael K. Cooper, Joshua B. Rubin, Linda M. Liau, Miklós Garami, Peter Hauser, Kay Ka Wai Li, Ho-Keung Ng, Wai Sang Poon, G. Yancey Gillespie, Jennifer A. Chan, Shin Jung, Roger E. McLendon, Eric M. Thompson, David Zagzag, Rajeev Vibhakar, Young Shin Ra, Maria Luisa Garre, Ulrich Schüller, Tomoko Shofuda, Claudia C. Faria, Enrique López-Aguilar, Gelareh Zadeh, Chi-Chung Hui, Vijay Ramaswamy, Swneke D. Bailey, Steven J. Jones, Andrew J. Mungall, Richard A. Moore, John A. Calarco, Lincoln D. Stein, Gary D. Bader, Jüri Reimand, Jiannis Ragoussis, William A. Weiss, Marco A. Marra, Hiromichi Suzuki, Michael D. Taylor

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)

Sonic Hedgehog medulloblastoma (Shh-MB) comprises four subtypes each with distinct clinical traits. Here the authors characterize the genome, transcriptome, and methylome of Shh-MB subtypes, revealing a complex fusion landscape and the molecular conv

Externí odkaz: https://doaj.org/article/091429a4162845e7a18371f487596c6f

Failure of human rhombic lip differentiation underlies medulloblastoma formation

Autor: Liam D. Hendrikse, Parthiv Haldipur, Olivier Saulnier, Jake Millman, Alexandria H. Sjoboen, Anders W. Erickson, Winnie Ong, Victor Gordon, Ludivine Coudière-Morrison, Audrey L. Mercier, Mohammad Shokouhian, Raúl A. Suárez, Michelle Ly, Stephanie Borlase, David S. Scott, Maria C. Vladoiu, Hamza Farooq, Olga Sirbu, Takuma Nakashima, Shohei Nambu, Yusuke Funakoshi, Alec Bahcheli, J. Javier Diaz-Mejia, Joseph Golser, Kathleen Bach, Tram Phuong-Bao, Patryk Skowron, Evan Y. Wang, Sachin A. Kumar, Polina Balin, Abhirami Visvanathan, John J. Y. Lee, Ramy Ayoub, Xin Chen, Xiaodi Chen, Karen L. Mungall, Betty Luu, Pierre Bérubé, Yu C. Wang, Stefan M. Pfister, Seung-Ki Kim, Olivier Delattre, Franck Bourdeaut, François Doz, Julien Masliah-Planchon, Wieslawa A. Grajkowska, James Loukides, Peter Dirks, Michelle Fèvre-Montange, Anne Jouvet, Pim J. French, Johan M. Kros, Karel Zitterbart, Swneke D. Bailey, Charles G. Eberhart, Amulya A. N. Rao, Caterina Giannini, James M. Olson, Miklós Garami, Peter Hauser, Joanna J. Phillips, Young S. Ra, Carmen de Torres, Jaume Mora, Kay K. W. Li, Ho-Keung Ng, Wai S. Poon, Ian F. Pollack, Enrique López-Aguilar, G. Yancey Gillespie, Timothy E. Van Meter, Tomoko Shofuda, Rajeev Vibhakar, Reid C. Thompson, Michael K. Cooper, Joshua B. Rubin, Toshihiro Kumabe, Shin Jung, Boleslaw Lach, Achille Iolascon, Veronica Ferrucci, Pasqualino de Antonellis, Massimo Zollo, Giuseppe Cinalli, Shenandoah Robinson, Duncan S. Stearns, Erwin G. Van Meir, Paola Porrati, Gaetano Finocchiaro, Maura Massimino, Carlos G. Carlotti, Claudia C. Faria, Martine F. Roussel, Frederick Boop, Jennifer A. Chan, Kimberly A. Aldinger, Ferechte Razavi, Evelina Silvestri, Roger E. McLendon, Eric M. Thompson, Marc Ansari, Maria L. Garre, Fernando Chico, Pilar Eguía, Mario Pérezpeña, A. Sorana Morrissy, Florence M. G. Cavalli, Xiaochong Wu, Craig Daniels, Jeremy N. Rich, Steven J. M. Jones, Richard A. Moore, Marco A. Marra, Xi Huang, Jüri Reimand, Poul H. Sorensen, Robert J. Wechsler-Reya, William A. Weiss, Trevor J. Pugh, Livia Garzia, Claudia L. Kleinman, Lincoln D. Stein, Nada Jabado, David Malkin, Olivier Ayrault, Jeffrey A. Golden, David W. Ellison, Brad Doble, Vijay Ramaswamy, Tamra E. Werbowetski-Ogilvie, Hiromichi Suzuki, Kathleen J. Millen, Michael D. Taylor

Publikováno v: Nature, 609(7929), 1021-1028. Nature Publishing Group
Nature

Medulloblastoma (MB) comprises a group of heterogeneous paediatric embryonal neoplasms of the hindbrain with strong links to early development of the hindbrain 1–4. Mutations that activate Sonic hedgehog signalling lead to Sonic hedgehog MB in the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66ec0922f019d862bd9bb29cccaa1865
https://doi.org/10.1038/s41586-022-05215-w

Supplementary Tables 1-6 from Pyrvinium Targets CD133 in Human Glioblastoma Brain Tumor–Initiating Cells

Autor: Sheila K. Singh, John A. Hassell, Mickie Bhatia, Bradley W. Doble, Naresh K. Murty, Kesava Reddy, John P. Provias, Boleslaw Lach, Thusyanth Vijayakumar, Neha Garg, David Bakhshinyan, Mohini Singh, Sara M. Nolte, Minomi Subapanditha, Nicole McFarlane, Maleeha A. Qazi, Sujeivan Mahendram, Branavan Manoranjan, Parvez Vora, Robin Hallett, Chitra Venugopal

Supplementary Tables 1-6. Supplementary Table 1: Clinico-pathological demographics of CD133high and CD133low GBM; Supplementary Table 2: Positive and negative correlation probe sets present in CD133-signature; Supplementary Table 3: Drug targets acqu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de78838d7c2f0c5240df40b3287c5a4a
https://doi.org/10.1158/1078-0432.22461183

Supplementary Figures 1-6 from Pyrvinium Targets CD133 in Human Glioblastoma Brain Tumor–Initiating Cells

Autor: Sheila K. Singh, John A. Hassell, Mickie Bhatia, Bradley W. Doble, Naresh K. Murty, Kesava Reddy, John P. Provias, Boleslaw Lach, Thusyanth Vijayakumar, Neha Garg, David Bakhshinyan, Mohini Singh, Sara M. Nolte, Minomi Subapanditha, Nicole McFarlane, Maleeha A. Qazi, Sujeivan Mahendram, Branavan Manoranjan, Parvez Vora, Robin Hallett, Chitra Venugopal

Supplementary Figures 1-6. Supplementary Figure 1: CD133 correlates patient outcome with GIC selfrenewal and proliferative capacities in human GBM; Supplementary Figure 2: Gene Set Enrichment Analysis (GSEA) results for embryonic stem cell gene sets

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::681815f4a53c686ab94a8ae9200b1e5d
https://doi.org/10.1158/1078-0432.22461186.v1

Supplementary Figure 1 from Spinal Myxopapillary Ependymomas Demonstrate a Warburg Phenotype

Autor: Michael D. Taylor, Gelareh Zadeh, Nada Jabado, Joanna J. Philips, Tarik Tihan, Melike Pekmezci, Andrey Korshunov, Stefan M. Pfister, James T. Rutka, Sidney Croul, Cynthia Hawkins, Abhijit Guha, William A. Weiss, Nalin Gupta, Boleslaw Lach, Wieslawa Grajkowska, Luca Massimi, Marina Ryzhova, Yuan Thompson, Marc Remke, Vijay Ramaswamy, Mark Barszczyk, Kory Zayne, Nadia Hill, Hendrik Witt, David J. Shih, Xin Wang, Kelsey C. Bertrand, Sameer Agnihotri, Stephen C. Mack

Supplementary Figure 1. Unsupervised consensus hierarchical clustering and non-negative matrix factorization of 35 spinal ependymoma gene expression signatures from a rank 2 to 4 classification.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ae68881f82b2111ca9327944cee8943
https://doi.org/10.1158/1078-0432.22457351.v1