The multikinase inhibitor Sorafenib displays significant antiproliferative effects and induces apoptosis via caspase 3, 7 and PARP in B- and T-lymphoblastic cells

Autor: Boldt Sonja, Fuellen Georg, Glass Aenne, Etro Daniela, Lange Sandra, Amoroso Francesca, Sawitzky Mandy, Ruck Sabine, Dahlhaus Meike, Schult Catrin, Wolkenhauer Olaf, Neri Luca, Freund Mathias, Junghanss Christian

Publikováno v: BMC Cancer, Vol 10, Iss 1, p 560 (2010)

Abstract Background Targeted therapy approaches have been successfully introduced into the treatment of several cancers. The multikinase inhibitor Sorafenib has antitumor activity in solid tumors and its effects on acute lymphoblastic leukemia (ALL)

Externí odkaz: https://doaj.org/article/951288d6987341d8b4297d10f4e64910

Gene Expression Analysis in Human Peripheral Blood Lymphocytes for Biodosimetric Applications after Low and High Dose Gamma-Irradiation

Autor: Knops, Katja, Boldt, Sonja, Wolkenhauer, Olaf, Kriehuber, Ralf

Publikováno v: 39th Annual Meeting of the European Radiation Research Society, ERRS, Vietri sul Mare, Italy, 2012-10-15-2012-10-19

Introduction: In case of a large-scale radiation accident with involvement of individuals without physical dosimeters it is important to identify individuals who have received a moderate to high radiation dose to ensure proper medical care. As curren

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3364::0771f887647b72e62f2a217ff5155752
https://hdl.handle.net/2128/15903

WHOLE GENOME EXPRESSION ANALYSIS IN HUMAN JURKAT CELLS AFTER EXPOSURE TO I-123-IODODEOXYURIDINE, γ-RAYS AND α-PARTICLES

Autor: Unverricht, Marcus, Boldt, Sonja, Giesen, Ulrich, Pomplun, Ekkehard, Wolkenhauer, Olaf, Kriehuber, Ralf

Publikováno v: 14. Jahrestagung der Gesellschaft für biologische Strahlenforschung, GBS, Rheinbach, Germany, 2011-09-13-2011-09-16
7th International Symposium on Physical, Molecular, Cellular and Medical Aspects of Auger Processes 2011, Jülich, Germany, 2011-08-24-2011-08-26

Introduction: In order to develop a gene expression profile-based method for biodosimetry purposes we used the human p53-deficient T-lymphoma Jurkat cell line to study whether gene signatures exist allowing the discrimination of radiation quality as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::30a07176f3fdb3a6a48ff921227908ea
https://hdl.handle.net/2128/16250

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.