Synthesis of Dihydropyridine Spirocycles by Semi-Pinacol-Driven Dearomatization of Pyridines.

Autor: Abell JC; School of Chemistry, University of Bristol, Cantock's Close, BristolBS8 1TS, U.K., Bold CP; School of Chemistry, University of Bristol, Cantock's Close, BristolBS8 1TS, U.K., Vicens L; School of Chemistry, University of Bristol, Cantock's Close, BristolBS8 1TS, U.K., Jentsch T; School of Chemistry, University of Bristol, Cantock's Close, BristolBS8 1TS, U.K., Velasco N; School of Chemistry, University of Bristol, Cantock's Close, BristolBS8 1TS, U.K., Tyler JL; School of Chemistry, University of Bristol, Cantock's Close, BristolBS8 1TS, U.K., Straker RN; UCB Pharma, 208 Bath Road, SloughSL1 3WE, U.K., Noble A; School of Chemistry, University of Bristol, Cantock's Close, BristolBS8 1TS, U.K., Aggarwal VK; School of Chemistry, University of Bristol, Cantock's Close, BristolBS8 1TS, U.K.

Publikováno v: Organic letters [Org Lett] 2023 Jan 20; Vol. 25 (2), pp. 400-404. Date of Electronic Publication: 2023 Jan 10.

Synthesis of Morpholine-Based Analogues of (-)-Zampanolide and Their Biological Activity.

Autor: Bold CP; Department of Chemistry and Applied Biosciences, Institute of Pharmaceutical Sciences, ETH Zurich HCI H405, Vladimir-Prelog-Weg 4, 8093, Zürich, Switzerland., Gut M; Department of Chemistry and Applied Biosciences, Institute of Pharmaceutical Sciences, ETH Zurich HCI H405, Vladimir-Prelog-Weg 4, 8093, Zürich, Switzerland., Schürmann J; Department of Chemistry and Applied Biosciences, Institute of Pharmaceutical Sciences, ETH Zurich HCI H405, Vladimir-Prelog-Weg 4, 8093, Zürich, Switzerland., Lucena-Agell D; Centro de Investigaciones Biolόgicas Margarita Salas, Consejo Superior de Investigaciones Científicas, Ramiro de Maeztu 9, 28040, Madrid, Spain., Gertsch J; Department of Chemistry and Applied Biosciences, Institute of Biochemistry and Molecular Medicine, University of Bern, Bühlstrasse 28, 3012, Bern, Switzerland., Díaz JF; Centro de Investigaciones Biolόgicas Margarita Salas, Consejo Superior de Investigaciones Científicas, Ramiro de Maeztu 9, 28040, Madrid, Spain., Altmann KH; Department of Chemistry and Applied Biosciences, Institute of Pharmaceutical Sciences, ETH Zurich HCI H405, Vladimir-Prelog-Weg 4, 8093, Zürich, Switzerland.

Publikováno v: Chemistry (Weinheim an der Bergstrasse, Germany) [Chemistry] 2021 Apr 01; Vol. 27 (19), pp. 5936-5943. Date of Electronic Publication: 2021 Mar 03.

Synthesis of Photoswitchable Δ ⁹ -Tetrahydrocannabinol Derivatives Enables Optical Control of Cannabinoid Receptor 1 Signaling.

Autor: Westphal MV; Laboratorium für Organische Chemie, Eidgenössische Technische Hochschule Zürich , Vladimir-Prelog-Weg 3, 8093 Zürich, Switzerland., Schafroth MA; Laboratorium für Organische Chemie, Eidgenössische Technische Hochschule Zürich , Vladimir-Prelog-Weg 3, 8093 Zürich, Switzerland., Sarott RC; Laboratorium für Organische Chemie, Eidgenössische Technische Hochschule Zürich , Vladimir-Prelog-Weg 3, 8093 Zürich, Switzerland., Imhof MA; Laboratorium für Organische Chemie, Eidgenössische Technische Hochschule Zürich , Vladimir-Prelog-Weg 3, 8093 Zürich, Switzerland., Bold CP; Laboratorium für Organische Chemie, Eidgenössische Technische Hochschule Zürich , Vladimir-Prelog-Weg 3, 8093 Zürich, Switzerland., Leippe P; Department of Chemistry and Center for Integrated Protein Science, Ludwig Maximilians University Munich , Butenandtstraße 5-13, 81377 Munich, Germany., Dhopeshwarkar A; Department of Psychological and Brain Sciences and the Gill Center, Indiana University , Bloomington, Indiana 47405, United States., Grandner JM; Department of Biological Sciences and Department of Chemistry, Bridge Institute, University of Southern California , Los Angeles, California 90089, United States., Katritch V; Department of Biological Sciences and Department of Chemistry, Bridge Institute, University of Southern California , Los Angeles, California 90089, United States., Mackie K; Department of Psychological and Brain Sciences and the Gill Center, Indiana University , Bloomington, Indiana 47405, United States., Trauner D; Department of Chemistry and Center for Integrated Protein Science, Ludwig Maximilians University Munich , Butenandtstraße 5-13, 81377 Munich, Germany.; Department of Chemistry, New York University , 100 Washington Square East, New York, New York 10003-6699, United States., Carreira EM; Laboratorium für Organische Chemie, Eidgenössische Technische Hochschule Zürich , Vladimir-Prelog-Weg 3, 8093 Zürich, Switzerland., Frank JA; Department of Chemistry and Center for Integrated Protein Science, Ludwig Maximilians University Munich , Butenandtstraße 5-13, 81377 Munich, Germany.

Publikováno v: Journal of the American Chemical Society [J Am Chem Soc] 2017 Dec 20; Vol. 139 (50), pp. 18206-18212. Date of Electronic Publication: 2017 Dec 12.