Výsledky vyhledávání - "Bola S, Hanna"

Akademický článek

Combining ibrutinib and checkpoint blockade improves CD8+ T-cell function and control of chronic lymphocytic leukemia in Em-TCL1 mice

Autor: Bola S. Hanna, Haniyeh Yazdanparast, Yasmin Demerdash, Philipp M. Roessner, Ralph Schulz, Peter Lichter, Stephan Stilgenbauer, Martina Seiffert

Publikováno v: Haematologica, Vol 106, Iss 4 (2020)

Ibrutinib is a bruton’s tyrosine kinase (BTK) inhibitor approved for the treatment of multiple B-cell malignancies, including chronic lymphocytic leukemia (CLL). In addition to blocking B-cell receptor signaling and chemokine receptor-mediated path

Externí odkaz: https://doaj.org/article/e1c4b619ea8642018da18ce254fffb71

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Akademický článek

Chd7 is indispensable for mammalian brain development through activation of a neuronal differentiation programme

Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)

Mutations in the chromatin modifier Chd7 have been associated with CHARGE syndrome and other developmental disorders. Here the authors show that Chd7 is required for the activation of genes essential for cerebellar granule cell differentiation, and t

Externí odkaz: https://doaj.org/article/a402443280f6419d867e3b5b78b484b1

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The potential for Treg-enhancing therapies in tissue, in particular skeletal muscle, regeneration

Autor: Bola S Hanna, Omar K Yaghi, P Kent Langston, Diane Mathis

Publikováno v: Clinical and Experimental Immunology. 211:138-148

Summary Foxp3+CD4+ regulatory T cells (Tregs) are famous for their role in maintaining immunological tolerance. With their distinct transcriptomes, growth-factor dependencies and T-cell receptor (TCR) repertoires, Tregs in nonlymphoid tissues, termed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71ad49be0317913ce36edb4f242a73ca
https://doi.org/10.1093/cei/uxac076

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Treg cells require Izumo1R to regulate γδT cell-driven inflammation in the skin

Autor: Payam Zarin, Yulia Shwartz, Adriana Ortiz-Lopez, Bola S. Hanna, Martina Sassone-Corsi, Ya-chieh Hsu, Diane Mathis, Christophe Benoist

Publikováno v: Proceedings of the National Academy of Sciences. 120

Izumo1R is a pseudo-folate receptor with an essential role in mediating tight oocyte/spermatozoa contacts during fertilization. Intriguingly, it is also expressed in CD4 + T lymphocytes, in particular Treg cells under the control of Foxp3. To underst

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f2831a0c2128ef96865da92f71481731
https://doi.org/10.1073/pnas.2221255120

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Akademický článek

Interferon-α2b Treatment for COVID-19 Is Associated with Improvements in Lung Abnormalities

Autor: Qiong Zhou, Michael R. MacArthur, Xinliang He, Xiaoshan Wei, Payam Zarin, Bola S. Hanna, Zi-Hao Wang, Xuan Xiang, Eleanor N. Fish

Publikováno v: Viruses, Vol 13, Iss 1, p 44 (2020)

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection causes coronavirus disease 2019 (COVID-19), a lung disease that may progress to systemic organ involvement and in some cases, death. The identification of the earliest predictors

Externí odkaz: https://doaj.org/article/ff10a612378149eb8d3ec9ecd4af6594

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Akademický článek

Tumor necrosis factor receptor signaling is a driver of chronic lymphocytic leukemia that can be therapeutically targeted by the flavonoid wogonin

Autor: Claudia Dürr, Bola S. Hanna, Angela Schulz, Fabienne Lucas, Manuela Zucknick, Axel Benner, Andrew Clear, Sibylle Ohl, Selcen Öztürk, Thorsten Zenz, Stephan Stilgenbauer, Min Li-Weber, Peter H. Krammer, John G. Gribben, Peter Lichter, Martina Seiffert

Publikováno v: Haematologica, Vol 103, Iss 4 (2018)

Chronic lymphocytic leukemia is a malignancy of mature B cells that strongly depend on microenvironmental factors, and their deprivation has been identified as a promising treatment approach for this incurable disease. Cytokine array screening of 247

Externí odkaz: https://doaj.org/article/7461f3c60f52471c8775596f026ea1d3

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A dynamic atlas of immunocyte migration from the gut

Autor: Silvia Galván-Peña, Yangyang Zhu, Bola S. Hanna, Diane Mathis, Christophe Benoist

SUMMARYDysbiosis in the gut microbiota impacts several systemic diseases. One possible mechanism is the migration of perturbed intestinal immunocytes to extra-intestinal tissues. Combining the Kaede photoconvertible mouse model and single-cell genomi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a656c4f8bcb71222738610a5dc732252
https://doi.org/10.1101/2022.11.16.516757

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Longitudinal analyses of CLL in mice identify leukemia-related clonal changes including a Myc gain predicting poor outcome in patients

Autor: Sascha Dietrich, Irene Gil-Farina, Selcen Öztürk, Marc Zapatka, Peter Lichter, Lavinia Arseni, Manfred Schmidt, Bola S. Hanna, Philipp M. Roessner, Anna Jauch, Stephan Stilgenbauer, Peter-Martin Bruch, Saira Afzal, Yashna Paul, Martina Seiffert, Verena Kalter

Publikováno v: Leukemia

Chronic lymphocytic leukemia (CLL) is a B-cell malignancy mainly occurring at an advanced age with no single major genetic driver. Transgenic expression of TCL1 in B cells leads after a long latency to a CLL-like disease in aged Eµ-TCL1 mice suggest

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be562e2e6a735f38acc00cd848da34c2
http://europepmc.org/articles/PMC8807396

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EOMES is essential for antitumor activity of CD8+ T cells in chronic lymphocytic leukemia

Autor: Ana Izcue, Marie Bordas, Bola S. Hanna, Vicente Chapaprieta, Martina Seiffert, Laura Llaó-Cid, Stephan Stilgenbauer, Philipp M. Roessner, Sascha Dietrich, Selcen Öztürk, José I. Martín-Subero, Tobias Roider, Dolors Colomer

Publikováno v: Leukemia
Leukemia : the Journal of Normal and Malignant Hemopoiese ; Official Journal of the Leukemia Research Fund U.K.
Leukemia : normal and malignant hemopoiesis 35(11), 3152-3162 (2021). doi:10.1038/s41375-021-01198-1

Leukemia : normal and malignant hemopoiesis 35(11), 3152-3162 (2021). doi:10.1038/s41375-021-01198-1
Published by Springer Nature, London

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9b9b72bf2015207654c0bd19358f944
http://europepmc.org/articles/PMC8550953

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