Zobrazeno 1 - 10
of 78
pro vyhledávání: '"Bokkyoo, Jun"'
Autor:
Sonia Do Carmo, Marie-Audrey I. Kautzmann, Surjyadipta Bhattacharjee, Bokkyoo Jun, Carolyn Steinberg, Joshua T. Emmerson, Janice C. Malcolm, Quentin Bonomo, Nicolas G. Bazan, A. Claudio Cuello
Publikováno v:
Journal of Neuroinflammation, Vol 21, Iss 1, Pp 1-21 (2024)
Abstract Background Brain inflammation contributes significantly to the pathophysiology of Alzheimer’s disease, and it is manifested by glial cell activation, increased production of cytokines/chemokines, and a shift in lipid mediators from a pro-h
Externí odkaz:
https://doaj.org/article/fe06cee141254d99843b373e4c10aee1
Autor:
Hernan A. Bazan, Surjyadipta Bhattacharjee, Madigan M. Reid, Bokkyoo Jun, Connor Polk, Madeleine Strain, Linsey A. St Pierre, Neehar Desai, Patrick W. Daly, Jessica A. Cucinello-Ragland, Scott Edwards, Javier Recio, Julio Alvarez-Builla, James J. Cai, Nicolas G. Bazan
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-35 (2024)
Abstract Safe and effective pain management is a critical healthcare and societal need. The potential for acute liver injury from paracetamol (ApAP) overdose; nephrotoxicity and gastrointestinal damage from chronic non-steroidal anti-inflammatory dru
Externí odkaz:
https://doaj.org/article/e955fc7d7b3b4d97b98770099763f826
Autor:
Nicolas G. Bazan, Andre Obenaus, Larissa Khoutorova, Pranab K. Mukherjee, Bokkyoo Jun, Rostyslav Semikov, Ludmila Belayev
Publikováno v:
Biomedicines, Vol 12, Iss 11, p 2555 (2024)
Background: In the United States, traumatic brain injury (TBI) contributes significantly to mortality and morbidity. Elovanoids (ELVs), a novel class of homeostatic lipid mediators we recently discovered and characterized, have demonstrated neuroprot
Externí odkaz:
https://doaj.org/article/01fc51d5ea8644eba3905677b8c18984
Autor:
Ceren Emre, Luis E. Arroyo-García, Khanh V. Do, Bokkyoo Jun, Makiko Ohshima, Silvia Gómez Alcalde, Megan L. Cothern, Silvia Maioli, Per Nilsson, Erik Hjorth, André Fisahn, Nicolas G. Bazan, Marianne Schultzberg
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-15 (2022)
Intranasal administration of pro-resolving lipid mediators improves memory deficits and reduce microglial activation in a mouse model for Alzheimer’s disease, suggesting a future therapy.
Externí odkaz:
https://doaj.org/article/19b3984474bb4b898093a4daa1c00e69
Autor:
Kiyoharu J. Miyagishima, Ruchi Sharma, Malika Nimmagadda, Katharina Clore-Gronenborn, Zoya Qureshy, Davide Ortolan, Devika Bose, Mitra Farnoodian, Congxiao Zhang, Andrew Fausey, Yuri V. Sergeev, Mones Abu-Asab, Bokkyoo Jun, Khanh V. Do, Marie-Audrey Kautzman Guerin, Jorgelina Calandria, Aman George, Bin Guan, Qin Wan, Rachel C. Sharp, Catherine Cukras, Paul A. Sieving, Robert B. Hufnagel, Nicolas G. Bazan, Kathleen Boesze-Battaglia, Sheldon Miller, Kapil Bharti
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-16 (2021)
Miyagishima et al. investigate the pathological mechanisms underlying mutant CTRP5 function in late-onset retinal degeneration (L-ORD). With human iPSC-derived RPE cells, they demonstrate that in L-ORD iRPE, constitutive activation of AMPK disrupts c
Externí odkaz:
https://doaj.org/article/24727da70edd48558b39804aab74c898
Autor:
Ceren Emre, Khanh V. Do, Bokkyoo Jun, Erik Hjorth, Silvia Gómez Alcalde, Marie-Audrey I. Kautzmann, William C. Gordon, Per Nilsson, Nicolas G. Bazan, Marianne Schultzberg
Publikováno v:
Acta Neuropathologica Communications, Vol 9, Iss 1, Pp 1-26 (2021)
Abstract Sustained brain chronic inflammation in Alzheimer’s disease (AD) includes glial cell activation, an increase in cytokines and chemokines, and lipid mediators (LMs), concomitant with decreased pro-homeostatic mediators. The inflammatory res
Externí odkaz:
https://doaj.org/article/ac96393851724d43b1cdd2767bc6342b
Autor:
Jorgelina M. Calandria, Surjyadipta Bhattacharjee, Nicholas J. Maness, Marie-Audrey I. Kautzmann, Aram Asatryan, William C. Gordon, Khanh V. Do, Bokkyoo Jun, Pranab K. Mukherjee, Nicos A. Petasis, Nicolas G. Bazan
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
Abstract The pro-homeostatic lipid mediators elovanoids (ELVs) attenuate cell binding and entrance of the SARS-CoV-2 receptor-binding domain (RBD) as well as of the SARS-CoV-2 virus in human primary alveoli cells in culture. We uncovered that very-lo
Externí odkaz:
https://doaj.org/article/23649788b0954184a9a2a7b9024ba830
Autor:
Aram Asatryan, Jorgelina M. Calandria, Marie-Audrey I. Kautzmann, Bokkyoo Jun, William C. Gordon, Khanh V. Do, Surjyadipta Bhattacharjee, Thang L. Pham, Vicente Bermúdez, Melina Valeria Mateos, Jessica Heap, Nicolas G. Bazan
Publikováno v:
Frontiers in Neuroscience, Vol 16 (2022)
Retinal pigment epithelial (RPE) cells sustain photoreceptor integrity, and when this function is disrupted, retinal degenerations ensue. Herein, we characterize a new cell line from human RPE that we termed ABC. These cells remarkably recapitulate h
Externí odkaz:
https://doaj.org/article/dc801f6830e94c9da53e42e67e678744
Autor:
Elisa Vidal, Bokkyoo Jun, William C. Gordon, Marie-Annick Maire, Lucy Martine, Stéphane Grégoire, Spiro Khoury, Stephanie Cabaret, Olivier Berdeaux, Niyazi Acar, Lionel Bretillon, Nicolas G. Bazan
Publikováno v:
Journal of Lipid Research, Vol 61, Iss 12, Pp 1733-1746 (2020)
Spatial changes of FAs in the retina in response to different dietary n-3 formulations have never been explored, although a diet rich in EPA and DHA is recommended to protect the retina against the effects of aging. In this study, Wistar rats were fe
Externí odkaz:
https://doaj.org/article/d155f70445f7465ca9a5c04c6c472343
Autor:
Yannick Das, Daniëlle Swinkels, Sai Kocherlakota, Stefan Vinckier, Frédéric M. Vaz, Eric Wever, Antoine H. C. van Kampen, Bokkyoo Jun, Khanh V. Do, Lieve Moons, Nicolas G. Bazan, Paul P. Van Veldhoven, Myriam Baes
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Patients lacking multifunctional protein 2 (MFP2), the central enzyme of the peroxisomal β-oxidation pathway, develop retinopathy. This pathway is involved in the metabolism of very long chain (VLCFAs) and polyunsaturated (PUFAs) fatty acids, which
Externí odkaz:
https://doaj.org/article/ac08bb97a2c74487a6bf594697e1540a