SARS-CoV-2 Specific Nanobodies Neutralize Different Variants of Concern and Reduce Virus Load in the Brain of h-ACE2 Transgenic Mice.

Autor: Pavan, María Florencia¹ (AUTHOR) mflorenciapavan@gmail.com, Bok, Marina^2,3 (AUTHOR) bok.marina@inta.gob.ar, Betanzos San Juan, Rafael⁴ (AUTHOR) rafael.betanzossj@gmail.com, Malito, Juan Pablo^2,3 (AUTHOR) malito.juanpablo@inta.gob.ar, Marcoppido, Gisela Ariana⁵ (AUTHOR) marcoppido.gisela@inta.gob.ar, Franco, Diego Rafael⁵ (AUTHOR) franco.diego@inta.gob.ar, Militelo, Daniela Ayelen¹ (AUTHOR) danielamilitello94@gmail.com, Schammas, Juan Manuel³ (AUTHOR), Bari, Sara Elizabeth¹ (AUTHOR) sara.elizabeth.bari@gmail.com, Stone, William⁶ (AUTHOR) wstone97@vt.edu, López, Krisangel⁶ (AUTHOR) klopez5@vt.edu, Porier, Danielle LaBrie⁶ (AUTHOR) danip@vt.edu, Muller, John Anthony⁶ (AUTHOR) jmuller51@vt.edu, Auguste, Albert Jonathan^6,7 (AUTHOR) jauguste@vt.edu, Yuan, Lijuan^7,8 (AUTHOR), Wigdorovitz, Andrés^2,3 (AUTHOR) awigdo@gmail.com, Parreño, Viviana Gladys^2,3,8 (AUTHOR) parreno.viviana@inta.gob.ar, Ibañez, Lorena Itat¹ (AUTHOR) parreno.viviana@inta.gob.ar

Publikováno v: Viruses (1999-4915). Feb2024, Vol. 16 Issue 2, p185. 25p.

Development of an IgY-Based Treatment to Control Bovine Coronavirus Diarrhea in Dairy Calves.

Autor: Bok, Marina^1,2,3 (AUTHOR) bok.marina@inta.gob.ar, Vega, Celina G.^1,2,3 (AUTHOR), Castells, Matias^4,5 (AUTHOR), Colina, Rodney^4,5 (AUTHOR), Wigdorovitz, Andrés^1,2,3 (AUTHOR), Parreño, Viviana^1,2,3 (AUTHOR) bok.marina@inta.gob.ar

Publikováno v: Viruses (1999-4915). Mar2023, Vol. 15 Issue 3, p708. 19p.

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Nanobodies against SARS-CoV-2 reduced virus load in the brain of challenged mice and neutralized Wuhan, Delta and Omicron Variants

Autor: Pavan, María Florencia, Bok, Marina, Juan, Rafael Betanzos San, Malito, Juan Pablo, Marcoppido, Gisela Ariana, Franco, Diego Rafael, Militello, Daniela Ayelen, Schammas, Juan Manuel, Bari, Sara, Stone, William B., López, Krisangel, Porier, Danielle L., Muller, John, Auguste, Albert J., Yuan, Lijuan, Wigdorovitz, Andrés, Parreño, Viviana, Ibañez, Lorena Itatí

Publikováno v: bioRxiv

In this work, we developed llama-derived nanobodies (Nbs) directed to the receptor binding domain (RBD) and other domains of the Spike (S) protein of SARS-CoV-2. Nanobodies were selected after the biopanning of two VHH-libraries, one of which was gen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::12cdc8ba616a81e1abae43319b7d1e21
https://europepmc.org/articles/PMC10054972/

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