Effect of a Strategy of Comprehensive Vasodilation vs Usual Care on Mortality and Heart Failure Rehospitalization Among Patients With Acute Heart Failure

Autor: Nikola, Kozhuharov, Assen, Goudev, Dayana, Flores, Micha T, Maeder, Joan, Walter, Samyut, Shrestha, Danielle Menosi, Gualandro, Mucio Tavares, de Oliveira Junior, Zaid, Sabti, Beat, Müller, Markus, Noveanu, Thenral, Socrates, Ronny, Ziller, Antoni, Bayés-Genís, Alessandro, Sionis, Patrick, Simon, Eleni, Michou, Samuel, Gujer, Tommaso, Gori, Philip, Wenzel, Otmar, Pfister, David, Conen, Ioannis, Kapos, Richard, Kobza, Hans, Rickli, Tobias, Breidthardt, Thomas, Münzel, Paul, Erne, Christian, Mueller, Micha, Maeder, Mucio, Tavares de Oliveira, Bojidar, Dimov, Sabine, Hartwiger, Nisha, Arenja, Bettina, Glatz, Natascha, Herr, Rahel, Isenrich, Tamina, Mosimann, Raphael, Twerenbold, Jasper, Boeddinghaus, Thomas, Nestelberger, Christian, Puelacher, Michael, Freese, Janine, Vögele, Kathrin, Meissner, Jasmin, Martin, Ivo, Strebel, Desiree, Wussler, Carmela, Schumacher, Stefan, Osswald, Fabian, Vogt, Jonas, Hilti, Sara, Barata, Deborah, Schneider, Jonas, Schwarz, Brigitte, Fitze, Katharina, Rentsch, Aline, Bossa, Sergio, Jallad, Alexandre, Soeiro, Dimitar, Georgiev, Thomas, Jansen, Gabriele, Gebel, Matthias, Bossard, Michael, Christ

Publikováno v: JAMA. 322:2292

Importance Short-term infusions of single vasodilators, usually given in a fixed dose, have not improved outcomes in patients with acute heart failure (AHF). Objective To evaluate the effect of a strategy that emphasized early intensive and sustained

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f62e22d8d3fbf14054e8a0b60ce4ee9a
https://doi.org/10.1001/jama.2019.18598

Effect of a Strategy of Comprehensive Vasodilation vs Usual Care on Mortality and Heart Failure Rehospitalization Among Patients With Acute Heart Failure: The GALACTIC Randomized Clinical Trial.

Autor: Kozhuharov N; Department of Cardiology and Cardiovascular Research Institute Basel (CRIB), University Hospital Basel, University of Basel, Basel, Switzerland.; GREAT Research Network, Rome, Italy., Goudev A; Queen Ioanna University Hospital Sofia, Department of Cardiology, Medical University of Sofia, Sofia, Bulgaria., Flores D; Department of Cardiology and Cardiovascular Research Institute Basel (CRIB), University Hospital Basel, University of Basel, Basel, Switzerland.; GREAT Research Network, Rome, Italy., Maeder MT; Department of Cardiology, Kantonsspital St Gallen, St Gallen, Switzerland., Walter J; Department of Cardiology and Cardiovascular Research Institute Basel (CRIB), University Hospital Basel, University of Basel, Basel, Switzerland.; GREAT Research Network, Rome, Italy.; Department of Internal Medicine, University Hospital Basel, University of Basel, Basel, Switzerland., Shrestha S; Department of Cardiology and Cardiovascular Research Institute Basel (CRIB), University Hospital Basel, University of Basel, Basel, Switzerland.; GREAT Research Network, Rome, Italy.; Department of Internal Medicine, University Hospital Basel, University of Basel, Basel, Switzerland., Gualandro DM; Department of Cardiology and Cardiovascular Research Institute Basel (CRIB), University Hospital Basel, University of Basel, Basel, Switzerland.; GREAT Research Network, Rome, Italy.; Heart Institute (INCOR), University of Sao Paulo Medical School, Sao Paulo, Brazil., de Oliveira Junior MT; Heart Institute (INCOR), University of Sao Paulo Medical School, Sao Paulo, Brazil., Sabti Z; Department of Cardiology and Cardiovascular Research Institute Basel (CRIB), University Hospital Basel, University of Basel, Basel, Switzerland.; GREAT Research Network, Rome, Italy., Müller B; Department of General Internal and Emergency Medicine, Medical University Clinic of the University of Basel, Kantonsspital Aarau, Aarau, Switzerland., Noveanu M; Department of Cardiology and Cardiovascular Research Institute Basel (CRIB), University Hospital Basel, University of Basel, Basel, Switzerland.; GREAT Research Network, Rome, Italy., Socrates T; Department of Cardiology and Cardiovascular Research Institute Basel (CRIB), University Hospital Basel, University of Basel, Basel, Switzerland.; GREAT Research Network, Rome, Italy.; Medical Outpatient Department, University Hospital Basel, University of Basel, Basel, Switzerland., Ziller R; Department of Cardiology and Cardiovascular Research Institute Basel (CRIB), University Hospital Basel, University of Basel, Basel, Switzerland.; GREAT Research Network, Rome, Italy., Bayés-Genís A; Heart Institute, Hospital Universitari Germans Trias i Pujol, CIBERCV, Department of Medicine, Autonomous University of Barcelona, Barcelona, Spain., Sionis A; Intensive Cardiac Care Unit, Cardiology Department, Hospital de la Santa Creu i Sant Pau, Biomedical Research Institute IIB-Sant Pau, Autonomous University of Barcelona, Barcelona, Spain., Simon P; Clinical Trial Unit, University Hospital Basel, Basel, Switzerland., Michou E; Department of Cardiology and Cardiovascular Research Institute Basel (CRIB), University Hospital Basel, University of Basel, Basel, Switzerland.; GREAT Research Network, Rome, Italy., Gujer S; Department of Cardiology, Luzerner Kantonsspital, Luzern, Switzerland.; Department of Internal Medicine, Kantonsspital Obwalden, Sarnen, Switzerland., Gori T; University Medical Center, Johannes Gutenberg University Mainz, Mainz, Germany., Wenzel P; University Medical Center, Johannes Gutenberg University Mainz, Mainz, Germany., Pfister O; Department of Cardiology and Cardiovascular Research Institute Basel (CRIB), University Hospital Basel, University of Basel, Basel, Switzerland.; GREAT Research Network, Rome, Italy., Conen D; Department of Cardiology and Cardiovascular Research Institute Basel (CRIB), University Hospital Basel, University of Basel, Basel, Switzerland.; GREAT Research Network, Rome, Italy.; Population Health Research Institute, McMaster University, Hamilton, Ontario, Canada., Kapos I; Department of Cardiology, Luzerner Kantonsspital, Luzern, Switzerland.; Department of Cardiology, University Hospital Zurich, Zurich, Switzerland., Kobza R; Department of Cardiology, Luzerner Kantonsspital, Luzern, Switzerland., Rickli H; Department of Cardiology, Kantonsspital St Gallen, St Gallen, Switzerland., Breidthardt T; Department of Cardiology and Cardiovascular Research Institute Basel (CRIB), University Hospital Basel, University of Basel, Basel, Switzerland.; GREAT Research Network, Rome, Italy.; Department of Internal Medicine, University Hospital Basel, University of Basel, Basel, Switzerland., Münzel T; University Medical Center, Johannes Gutenberg University Mainz, Mainz, Germany., Erne P; Department of Cardiology, Luzerner Kantonsspital, Luzern, Switzerland., Mueller C; Department of Cardiology and Cardiovascular Research Institute Basel (CRIB), University Hospital Basel, University of Basel, Basel, Switzerland.; GREAT Research Network, Rome, Italy., Mueller, Erne, Müller, Rickli, Maeder, Tavares de Oliveira Jr, Münzel, Bayés-Genís, Sionis, Goudev, Dimov, Hartwiger, Arenja N, Glatz, Herr, Isenrich, Mosimann, Twerenbold, Boeddinghaus, Nestelberger, Puelacher, Freese, Vögele, Meissner, Martin, Strebel, Wussler, Schumacher, Osswald, Vogt, Hilti, Barata, Schneider, Schwarz, Fitze, Hartwiger, Arenja, Glatz, Herr, Isenrich, Mosimann, Twerenbold, Boeddinghaus, Nestelberger, Puelacher, Freese, Vögele, Meissner, Martin, Strebel, Wussler, Schumacher, Osswald, Vogt, Hilti, Barata, Schneider, Schwarz, Fitze, Arenja, Rentsch, Bossa, Jallad, Soeiro, Georgiev, Jansen, Gebel, Bossard, Christ

Publikováno v: JAMA [JAMA] 2019 Dec 17; Vol. 322 (23), pp. 2292-2302.