Stepwise in vitro screening of MMV pathogen box compounds against Plasmodium falciparum to identify potent antimalarial candidates

Autor: Mbye, Haddijatou, Bojang, Fatoumata, Jaiteh, Fatou Kene, Jawara, Aminata, Njie, Bekai, Correa, Simon, D'Alessandro, Umberto, Amambua-Ngwa, Alfred

Publikováno v: In International Journal for Parasitology: Drugs and Drug Resistance August 2023 22:81-87

Transcriptome analysis reveals molecular targets of erythrocyte invasion phenotype diversity in natural Plasmodium falciparum isolates from Cameroon.

Autor: Ngoh, Ines A., Mane, Karim, Manneh, Jarra, Bojang, Fatoumata, Jawara, Aminata S., Akenji, Theresia N., Anong, Damian N., D’Alessandro, Umberto, Amambua-Ngwa, Alfred

Publikováno v: Frontiers in Parasitology; 2024, p1-13, 13p

Tolerance of Gambian Plasmodium falciparum to Dihydroartemisinin and Lumefantrine detected by Ex vivo Parasite Survival Rate Assay

Autor: Mbye, Haddijatou, Bojang, Fatoumata, Jawara, Aminata Seedy, Njie, Bekai, Mohammed, Nuredin Ibrahim, Okebe, Joseph, D'Alessandro, Umberto, Amambua-Ngwa, Alfred

Monitoring of Plasmodium falciparum sensitivity to antimalarial drugs in Africa is vital for malaria elimination. However, the commonly used ex vivo/in vitro 50% inhibitory concentration (IC50) test gives inconsistent results for several antimalarial

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Tolerance of Gambian Plasmodium falciparum to Dihydroartemisinin and Lumefantrine Detected by Ex Vivo Parasite Survival Rate Assay.

Autor: Mbye H; West African Centre for Cell Biology of Infectious Pathogens, Department of Biochemistry, Cell and Molecular Biology, University of Ghana, Legon, Ghana.; MRC Unit The Gambia at London School of Hygiene and Tropical Medicine, Fajara, The Gambia., Bojang F; MRC Unit The Gambia at London School of Hygiene and Tropical Medicine, Fajara, The Gambia., Jawara AS; MRC Unit The Gambia at London School of Hygiene and Tropical Medicine, Fajara, The Gambia., Njie B; MRC Unit The Gambia at London School of Hygiene and Tropical Medicine, Fajara, The Gambia., Mohammed NI; MRC Unit The Gambia at London School of Hygiene and Tropical Medicine, Fajara, The Gambia., Okebe J; Department of International Public Health, Liverpool School of Tropical Medicine, United Kingdom., D'Alessandro U; MRC Unit The Gambia at London School of Hygiene and Tropical Medicine, Fajara, The Gambia.; London School of Hygiene and Tropical Medicine, London, United Kingdom., Amambua-Ngwa A; MRC Unit The Gambia at London School of Hygiene and Tropical Medicine, Fajara, The Gambia angwa@mrc.gm.; London School of Hygiene and Tropical Medicine, London, United Kingdom.

Publikováno v: Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2020 Dec 16; Vol. 65 (1). Date of Electronic Publication: 2020 Dec 16 (Print Publication: 2020).