Intestinal Stem Cell Pool Regulation in Drosophila

Autor: Yinhua Jin, Parthive H. Patel, Alexander Kohlmaier, Bojana Pavlovic, Chenge Zhang, Bruce A. Edgar

Publikováno v: Stem Cell Reports, Vol 8, Iss 6, Pp 1479-1487 (2017)

Intestinal epithelial renewal is mediated by intestinal stem cells (ISCs) that exist in a state of neutral drift, wherein individual ISC lineages are regularly lost and born but ISC numbers remain constant. To test whether an active mechanism maintai

Externí odkaz: https://doaj.org/article/60ba1a9a486e4aba9b9b31b6b2ec3b19

Damage sensing by a Nox-Ask1-MKK3-p38 signaling pathway mediates regeneration in the adult Drosophila midgut

Autor: Aurelio A. Teleman, Bojana Pavlovic, Michael Kardorff, Clothilde Pénalva, Anja Thiel, Bruce A. Edgar, Parthive H. Patel, Marianne Roca

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Patel, P H, Pénalva, C, Kardorff, M, Roca, M, Pavlović, B, Thiel, A, Teleman, A A & Edgar, B A 2019, ' Damage sensing by a Nox-Ask1-MKK3-p38 signaling pathway mediates regeneration in the adult Drosophila midgut ', Nature Communications, vol. 10, no. 1, 4365 (2019) . https://doi.org/10.1038/s41467-019-12336-w
Nature Communications
Patel, P H, Pénalva, C, Kardorff, M, Roca, M, Pavlović, B, Thiel, A, Teleman, A A & Edgar, B A 2019, ' Damage sensing by a Nox-Ask1-MKK3-p38 signaling pathway mediates regeneration in the adult Drosophila midgut ', Nature Communications, vol. 10, 4365 (2019) . https://doi.org/10.1038/s41467-019-12336-w

Epithelia are exposed to diverse types of stress and damage from pathogens and the environment, and respond by regenerating. Yet, the proximal mechanisms that sense epithelial damage remain poorly understood. Here we report that p38 signaling is acti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5f1115784816edbeedc25467d5e79e7
http://link.springer.com/article/10.1038/s41467-019-12336-w

Author response: Systematic functional analysis of rab GTPases reveals limits of neuronal robustness to environmental challenges in flies

Autor: Friederike Elisabeth Kohrs, F Ridvan Kiral, Heike Wolfenberg, Thomas F. Mathejczyk, Ilsa-Maria Daumann, Eugene Jennifer Jin, Shih-Ching Lin, Filip Port, P. Robin Hiesinger, Gerit A. Linneweber, Chih-Chiang Chan, Michael Boutros, Bojana Pavlovic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ac6e2b95bad4c9bdc75b60aa63dcecc6
https://doi.org/10.7554/elife.59594.sa2

Author response: A large-scale resource for tissue-specific CRISPR mutagenesis in Drosophila

Autor: Laura Lange, Fillip Port, Kristin Rädecke, Amy Hess, Jana Frei, Mona Stricker, Lukas Voos, Bojana Pavlovic, Nora Langner, Roberta Malamud, Florian Heigwer, Jun Zhou, Katharina Kern, Lukas Schmitt, Erica Valentini, Michael Boutros, Claudia Strein, Celine Beyersdörffer, Benedikt Rauscher

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fe1b13c77ba3f4437f1dec7a5dc4490d
https://doi.org/10.7554/elife.53865.sa2

A large-scale resource for tissue-specific CRISPR mutagenesis in Drosophila

Autor: Bojana Pavlovic, Amy Hess, Kristin Rädecke, Fillip Port, Erica Valentini, Katharina Kern, Lukas Voos, Florian Heigwer, Celine Beyersdörffer, Lukas Schmitt, Jana Frei, Benedikt Rauscher, Claudia Strein, Roberta Malamud, Mona Stricker, Jun Zhou, Michael Boutros

SUMMARYGenetic screens are powerful tools for the functional annotation of genomes. In the context of multicellular organisms, interrogation of gene function is greatly facilitated by methods that allow spatial and temporal control of gene abrogation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a21e6ba6691db0a5ea320d5a5eefa41