Zobrazeno 1 - 5
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pro vyhledávání: '"Bojan Garic"'
Intensive urbanization and global warming are impacting the health and well-being of urban population. Nevertheless, urban environments with different design will have different micro and local climate conditions. Therefore, the application of parame
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c9e8766b48963c62e647c66a5a85154b
https://doi.org/10.5194/ems2022-300
https://doi.org/10.5194/ems2022-300
Publikováno v:
Journal of Biological Chemistry. 285:33898-33905
Kv2.1 channels, which are expressed in brain, heart, pancreas, and other organs and tissues, are important targets for drug design. Flecainide and propafenone are known to block Kv2.1 channels more potently than other Kv channels. Here, we sought to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f9f21233fa55ff27f067e96716f92e4
https://doi.org/10.1074/jbc.m110.159897
https://doi.org/10.1074/jbc.m110.159897
Autor:
Bojan Garic, Cedrick Mahieux, Boris S. Zhorov, Silke B. Bodendiek, Pavel I. Zimin, Heike Wulff
Publikováno v:
Molecular Pharmacology. 78:588-599
Voltage-gated potassium channels (Kv) are targets for drugs of large chemical diversity. Although hydrophobic cations block Kv channels with Hill coefficients of 1, uncharged electron-rich (cationophilic) molecules often display Hill coefficients of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d209ec1360a387e2a71e855cf9c238ea
https://doi.org/10.1124/mol.110.064014
https://doi.org/10.1124/mol.110.064014
Publikováno v:
Biophysical Journal. 96(3)
Kv1.3 is widely regarded as an attractive drug target for the treatment of effector memory T cell-mediated autoimmune diseases such as multiple sclerosis, type-1 diabetes and psoriasis. Schmitz et al. (2005) identified 5-(4-phenoxybutoxy)psoralen (PA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e8388b181503e177565858496ede13c
Publikováno v:
Biophysical Journal. (3):115a
Potassium channels are targets for medically important drugs of large chemical diversity. While classical hydrophilic cations like tetraethylammonium block Kv channels with a stoichiometry of 1:1, many uncharged lipophilic (neutral) compounds exhibit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e11cfeed05584d4b82adfc29b470725e