Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Bojan Doljak"'
Publikováno v:
Acta Chimica Slovenica, Vol 64, Iss 1, Pp 1-14 (2017)
Mutagenic impurities (MIs) are of serious concern for pharmaceutical industry, regulatory agencies and public health. The first guideline addressing the control of genotoxic impurities (GTIs) dates back to 2006. Since then there have been several upd
Externí odkaz:
https://doaj.org/article/155084f116a64215bd221bae614d4bc5
Autor:
Urša Pečar Fonović, Zala Jevnikar, Matija Rojnik, Bojan Doljak, Marko Fonović, Polona Jamnik, Janko Kos
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e53918 (2013)
Cathepsin X has been reported to be a tumor promotion factor in various types of cancer; however, the molecular mechanisms linking its activity with malignant processes are not understood. Here we present profilin 1, a known tumor suppressor, as a ta
Externí odkaz:
https://doaj.org/article/0fbd64b2e4e04857af9d3559d0c795d3
Publikováno v:
Organic Process Research & Development. 22:125-135
The nature of the starting material (SM) and the presence of (potentially) mutagenic impurities (PMIs) can correlate strongly, since many syntheses involve the use of potentially mutagenic electrophilic (alkylating) agents as SMs. Since the regulator
Autor:
Astrid Satler, Renata Toplak Časar, Bojan Doljak, Nevenka Kragelj Lapanja, Borut Zupančič, Sabina Jurca, Damir Orkič, Matjaž Uštar
Publikováno v:
Organic Process Research & Development. 19:1524-1530
Determination of theoretical purge factors for the evaluation of risk of carryover of potential mutagenic impurities (MIs) into the final active pharmaceutical ingredient (API) has been discussed as a possible approach to demonstrate efficient purifi
Autor:
Bojan Doljak, Urša Pečar Fonović, Anja Pišlar, Tanja Jakoš, Janko Kos, Ana Mitrović, Stanislav Gobec, Boris Brus, Simon Žakelj, Jure Stojan, Jurij Trontelj, Damijan Knez
Publikováno v:
Scientific Reports
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Cathepsin X is a cysteine peptidase involved in the progression of cancer and neurodegenerative diseases. Targeting this enzyme with selective inhibitors opens a new possibility for intervention in several therapeutic areas. In this study triazole-ba
Publikováno v:
Acta Chimica Slovenica, Vol 64, Iss 1, Pp 1-14 (2017)
Acta chimica slovenica
Acta chimica slovenica
Mutagenic impurities (MIs) are of serious concern for pharmaceutical industry, regulatory agencies and public health. The first guideline addressing the control of genotoxic impurities (GTIs) dates back to 2006. Since then there have been several upd
Autor:
Vesna Hodnik, Aleš Premzl, Bojana Mirković, Zala Jevnikar, Bojan Doljak, Janko Kos, Gregor Anderluh
Publikováno v:
FEBS Journal. 276:4739-4751
Cathepsin B (EC 3.4.22.1) is a lysosomal cysteine protease with both endopeptidase and exopeptidase activity. The former is associated with the degradation of the extracellular matrix proteins, which is a process required for tumour cell invasion and
Publikováno v:
Phytotherapy Research. 23:874-877
Lipids are important components in human nutrition; however, their increased intake contributes to the development of obesity and can lead to multiple long-term complications. Pancreatic lipase (triacylglycerol acylhydrolase, EC 3.1.1.3) is a key enz
Publikováno v:
Connective Tissue Research. 49:193-196
Cysteine cathepsins participate in extracellular matrix (ECM) degradation and remodelling and thus influence important cellular processes such as cell transformation and differentiation, motility, adhesion, invasion, angiogenesis, and metastasis. Als
Autor:
V. Lucchini, Marina Zacchigna, Bojan Doljak, Giuseppe Procida, Marko Anderluh, Francesca Cateni
Two new triterpene acids (1, 2), together with a complex mixture of lecithins (3), were isolated from the fungus Gloeophyllum odoratum. Their structures were elucidated on the basis of extensive spectroscopic analyses. The extract of Gloeophyllum odo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d80c9679191d0cd7d3f97a94e3469baa
https://hdl.handle.net/11368/2831713
https://hdl.handle.net/11368/2831713