Výsledky vyhledávání - "Bojan Bister"

Akademický článek

Physiologically‐Based Pharmacokinetic Modeling Analysis for Quantitative Prediction of Renal Transporter–Mediated Interactions Between Metformin and Cimetidine

Autor: Kotaro Nishiyama, Kota Toshimoto, Wooin Lee, Naoki Ishiguro, Bojan Bister, Yuichi Sugiyama

Publikováno v: CPT: Pharmacometrics & Systems Pharmacology, Vol 8, Iss 6, Pp 396-406 (2019)

Metformin is an important antidiabetic drug and often used as a probe for drug–drug interactions (DDIs) mediated by renal transporters. Despite evidence supporting the inhibition of multidrug and toxin extrusion proteins as the likely DDI mechanism

Externí odkaz: https://doaj.org/article/1d993496b36543679193b295682659e8

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Impact of Direction of Transport on the Evaluation of Substrate Recognition of Mouse Multidrug and Toxin Extrusion Protein 1

Autor: Asami Saito, Tomoko Kito, Naoki Ishiguro, Masahito Takatani, Takashi Kudo, Bojan Bister, Hiroyuki Kusuhara

Publikováno v: Drug Metabolism and Disposition. 51:583-590

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a4bfaf35b9cb3580ceb7d4613b8463dd
https://doi.org/10.1124/dmd.122.001115

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Considerations for Human ADME Strategy and Design Paradigm Shift(s) - An Industry White Paper

Autor: Graeme C. Young, Douglas K. Spracklin, Alexander D. James, Mette G. Hvenegaard, Graeme Scarfe, David S. Wagner, Katrin Georgi, Hanno Schieferstein, Inga Bjornsdottir, Bianca van Groen, Andrea A. Romeo, Kenneth C. Cassidy, Georges Da‐violante, Bojan Bister, Stefan Blech, Ramaswamy Lyer, Simone I. Schulz, Filip Cuyckens, Patricia Moliner

Publikováno v: Clinical pharmacology and therapeutics.

The human absorption, distribution, metabolism, and excretion (hADME) study is the cornerstone of the clinical pharmacology package for small molecule drugs, providing comprehensive information on the rates and routes of disposition and elimination o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a566446fc962ea5d24f6a463ffa80700
https://pubmed.ncbi.nlm.nih.gov/35733280

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Physiologically‐Based Pharmacokinetic Modeling Analysis for Quantitative Prediction of Renal Transporter–Mediated Interactions Between Metformin and Cimetidine

Autor: Kota Toshimoto, Wooin Lee, Naoki Ishiguro, Bojan Bister, Kotaro Nishiyama, Yuichi Sugiyama

Publikováno v: CPT: Pharmacometrics & Systems Pharmacology, Vol 8, Iss 6, Pp 396-406 (2019)
CPT: Pharmacometrics & Systems Pharmacology

Metformin is an important antidiabetic drug and often used as a probe for drug-drug interactions (DDIs) mediated by renal transporters. Despite evidence supporting the inhibition of multidrug and toxin extrusion proteins as the likely DDI mechanism,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf69f911005aaa3603bb44f7669b52dc
https://doaj.org/article/1d993496b36543679193b295682659e8

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Impact of Direction of Transport on the Evaluation of Inhibition Potencies of Multidrug and Toxin Extrusion Protein 1 Inhibitors

Autor: Asami Saito, Masahito Takatani, Hiroyuki Kusuhara, Naoki Ishiguro, Bojan Bister

Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 49(2)

Multidrug and toxin extrusion (MATE) transporters are expressed on the luminal membrane of renal proximal tubule cells and extrude their substrates into the luminal side of the tubules. Inhibition of MATE1 can reduce renal secretory clearance of its

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12b5d195fdf3002bd7948c3d5122d191
https://pubmed.ncbi.nlm.nih.gov/33262224

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A Decade in the MIST: Learnings from Investigations of Drug Metabolites in Drug Development under the 'Metabolites in Safety Testing' Regulatory Guidance

Autor: Cornelis E. C. A. Hop, Swapan Chowdhury, Douglas K. Spracklin, Simone Schadt, Christoph Funk, W. Griffith Humphreys, Angus N. R. Nedderman, Fumihiko Igarashi, Josh Yuan, Chandra Prakash, Frank Runge, Holger Scheible, Mark Kagan, S. Cyrus Khojasteh, Piet Swart, R. Scott Obach, Bojan Bister, Alexander David James, Susanna Tse

Publikováno v: BASE-Bielefeld Academic Search Engine

Since the introduction of metabolites in safety testing (MIST) guidance by the Food and Drug Administration in 2008, major changes have occurred in the experimental methods for the identification and quantification of metabolites, ways to evaluate co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28c0739606a23742034a3be6254e08fa
https://doi.org/10.1124/dmd.117.079848

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Effect of endogenous multidrug resistance 1 and P-glycoprotein expression on anticancer drug resistance in colon cancer cell lines

Autor: Ikumi Tamai, Naoki Ishiguro, Takeo Nakanishi, Ikumi Washio, Bojan Bister

Publikováno v: Biopharmaceuticsdrug disposition. 40(1)

P-glycoprotein (P-gp, multidrug resistance 1 (MDR1)) overexpression confers multidrug resistance to cancer cells, and P-gp in cell lines transfected with MDR1 or selected with chemotherapeutics significantly affect the anticancer drug efficacy. Altho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::808dc7b6f4eedd2a2f2276553f28557f
https://pubmed.ncbi.nlm.nih.gov/30556139

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Efficacy of the highly selective focal adhesion kinase inhibitor BI 853520 in adenocarcinoma xenograft models is linked to a mesenchymal tumor phenotype

Autor: Norbert Schweifer, Norbert Kraut, Gerd Bader, Sapountzis Ioannis, Jürgen Braunger, Irene Waizenegger, Anke Baum, Günther R. Adolf, Ulrich Hirt, Jens Quant, Daniel Gerlach, Bojan Bister, Heinz Stadtmüller, Andreas Zoephel, Ulrike Weyer-Czernilofsky, Christian Haslinger, Pilar Garin-Chesa

Publikováno v: Oncogenesis
Oncogenesis, Vol 7, Iss 2, Pp 1-11 (2018)

Focal adhesion kinase (FAK), a non-receptor tyrosine kinase, has attracted interest as a target for pharmacological intervention in malignant diseases. Here, we describe BI 853520, a novel ATP-competitive inhibitor distinguished by high potency and s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::681e7282894ee5213882f605e9ac268d
https://doi.org/10.1038/s41389-018-0032-z

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The detection of salmochelin and yersiniabactin in uropathogenic strains by a novel hydrolysis-fluorescence-detection (HFD) method

Autor: Günther Winkelmann, Bojan Bister, Klaus Hantke, Marianne Valdebenito, Rolf Reissbrodt

Publikováno v: International Journal of Medical Microbiology. 295:99-107

Escherichia coli strains produce a variety of structurally different siderophores of which enterobactin, aerobactin and yersiniabactin have been reported earlier to occur in strains of extraintestinal infections. In uropathogenic E. coli (UPEC) strai

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::55f60474c638cabadbe9fe1a4a96671a
https://doi.org/10.1016/j.ijmm.2005.02.001

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A Regioselective Tryptophan 5-Halogenase Is Involved in Pyrroindomycin Biosynthesis in Streptomyces rugosporus LL-42D005

Autor: Bojan Bister, Karl-Heinz van Pée, Susanne Zehner, José A. Salas, Carmen Méndez, Roderich D. Süssmuth, Alexander Kotzsch

Publikováno v: Chemistry & Biology. 12(4):445-452

Summary The antibiotic compound pyrroindomycin B contains an indole ring chlorinated in the 5 position. The indole ring is probably derived from tryptophan, and thus primers derived from conserved regions of tryptophan halogenases were used to amplif

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52d77e56b70678ab28bdc2537c0c454c

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