Výsledky vyhledávání - "Bojan Bister"

Akademický článek

Physiologically‐Based Pharmacokinetic Modeling Analysis for Quantitative Prediction of Renal Transporter–Mediated Interactions Between Metformin and Cimetidine

Autor: Kotaro Nishiyama, Kota Toshimoto, Wooin Lee, Naoki Ishiguro, Bojan Bister, Yuichi Sugiyama

Publikováno v: CPT: Pharmacometrics & Systems Pharmacology, Vol 8, Iss 6, Pp 396-406 (2019)

Metformin is an important antidiabetic drug and often used as a probe for drug–drug interactions (DDIs) mediated by renal transporters. Despite evidence supporting the inhibition of multidrug and toxin extrusion proteins as the likely DDI mechanism

Externí odkaz: https://doaj.org/article/1d993496b36543679193b295682659e8

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Periodical

A Phosphorane as Supported Acylanion Equivalent: Linker Reagents for Smooth and Versatile C&bond;C Coupling Reactions Part of this work was presented at the ORCHEM 2002 in Bad Nauheim (Germany). We gratefully acknowledge generous support from Prof. G. Jung and from Prof. M. E. Maier, Tübingen, the Strukturfonds of the University of Tübingen, DFG project Reactive Intermediates in Polymeric Gels (Ra 895/2), from the Fonds der Chemischen Industrie, Novabiochem AG (Läufelfingen, Switzerland), and Personal Chemistry GmbH (Konstanz (Germany)). We thank Andreas Petri, Bojan Bister and Daniel Bischoff for analytical support.

Autor: Weik, Steffen, Rademann, Jörg

Publikováno v: Angewandte Chemie. International Edition; June 6, 2003, Vol. 42 Issue: 22 p2491-2494, 4p

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Impact of Direction of Transport on the Evaluation of Substrate Recognition of Mouse Multidrug and Toxin Extrusion Protein 1

Autor: Asami Saito, Tomoko Kito, Naoki Ishiguro, Masahito Takatani, Takashi Kudo, Bojan Bister, Hiroyuki Kusuhara

Publikováno v: Drug Metabolism and Disposition. 51:583-590

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a4bfaf35b9cb3580ceb7d4613b8463dd
https://doi.org/10.1124/dmd.122.001115

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Considerations for Human ADME Strategy and Design Paradigm Shift(s) - An Industry White Paper

Autor: Graeme C. Young, Douglas K. Spracklin, Alexander D. James, Mette G. Hvenegaard, Graeme Scarfe, David S. Wagner, Katrin Georgi, Hanno Schieferstein, Inga Bjornsdottir, Bianca van Groen, Andrea A. Romeo, Kenneth C. Cassidy, Georges Da‐violante, Bojan Bister, Stefan Blech, Ramaswamy Lyer, Simone I. Schulz, Filip Cuyckens, Patricia Moliner

Publikováno v: Clinical pharmacology and therapeutics.

The human absorption, distribution, metabolism, and excretion (hADME) study is the cornerstone of the clinical pharmacology package for small molecule drugs, providing comprehensive information on the rates and routes of disposition and elimination o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a566446fc962ea5d24f6a463ffa80700
https://pubmed.ncbi.nlm.nih.gov/35733280

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Physiologically‐Based Pharmacokinetic Modeling Analysis for Quantitative Prediction of Renal Transporter–Mediated Interactions Between Metformin and Cimetidine

Autor: Kota Toshimoto, Wooin Lee, Naoki Ishiguro, Bojan Bister, Kotaro Nishiyama, Yuichi Sugiyama

Publikováno v: CPT: Pharmacometrics & Systems Pharmacology, Vol 8, Iss 6, Pp 396-406 (2019)
CPT: Pharmacometrics & Systems Pharmacology

Metformin is an important antidiabetic drug and often used as a probe for drug-drug interactions (DDIs) mediated by renal transporters. Despite evidence supporting the inhibition of multidrug and toxin extrusion proteins as the likely DDI mechanism,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf69f911005aaa3603bb44f7669b52dc
https://doaj.org/article/1d993496b36543679193b295682659e8

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Impact of Direction of Transport on the Evaluation of Inhibition Potencies of Multidrug and Toxin Extrusion Protein 1 Inhibitors

Autor: Asami Saito, Masahito Takatani, Hiroyuki Kusuhara, Naoki Ishiguro, Bojan Bister

Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 49(2)

Multidrug and toxin extrusion (MATE) transporters are expressed on the luminal membrane of renal proximal tubule cells and extrude their substrates into the luminal side of the tubules. Inhibition of MATE1 can reduce renal secretory clearance of its

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12b5d195fdf3002bd7948c3d5122d191
https://pubmed.ncbi.nlm.nih.gov/33262224

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A Decade in the MIST: Learnings from Investigations of Drug Metabolites in Drug Development under the 'Metabolites in Safety Testing' Regulatory Guidance

Autor: Cornelis E. C. A. Hop, Swapan Chowdhury, Douglas K. Spracklin, Simone Schadt, Christoph Funk, W. Griffith Humphreys, Angus N. R. Nedderman, Fumihiko Igarashi, Josh Yuan, Chandra Prakash, Frank Runge, Holger Scheible, Mark Kagan, S. Cyrus Khojasteh, Piet Swart, R. Scott Obach, Bojan Bister, Alexander David James, Susanna Tse

Publikováno v: BASE-Bielefeld Academic Search Engine

Since the introduction of metabolites in safety testing (MIST) guidance by the Food and Drug Administration in 2008, major changes have occurred in the experimental methods for the identification and quantification of metabolites, ways to evaluate co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28c0739606a23742034a3be6254e08fa
https://doi.org/10.1124/dmd.117.079848

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Akademický článek

A Phosphorane as Supported Acylanion Equivalent: Linker Reagents for Smooth and Versatile C—C Coupling Reactions ( Part of this work was presented at the ORCHEM 2002 in Bad Nauheim (Germany). We gratefully acknowledge generous support from Prof. G. Jung and from Prof. M. E. Maier, Tübingen, the Strukturfonds of the University of Tübingen, DFG project Reactive Intermediates in Polymeric Gels (Ra 895/2), from the Fonds der Chemischen Industrie, Novabiochem AG (Läufelfingen, Switzerland), and Personal Chemistry GmbH (Konstanz (Germany)). We thank Andreas Petri, Bojan Bister and Daniel Bischoff for analytical support. )

Autor: Steffen Weik, Jörg Rademann

Publikováno v: Angewandte Chemie International Edition; Jun2003, Vol. 42 Issue 22, p2491-2494, 4p

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Akademický článek

Ein Phosphoran als polymergebundenes Acylanionenäquivalent: Linkerreagentien für schonende und vielseitige C-C-Kupplungen ( Ein Teil dieser Arbeit wurde auf der ORCHEM 2002 in Bad Nauheim präsentiert. Wir bedanken uns für die großzügige Unterstützung durch Prof. G. Jung und Prof. M. E. Maier, Tübingen, den Strukturfonds der Universität Tübingen, das DFG-Projekt Reaktive Intermediate in polymeren Gelen (Ra 895/2), den Fonds der Chemischen Industrie, die Novabiochem AG (Läufelfingen, Schweiz) und die Personal Chemistry GmbH (Konstanz). Wir danken Andreas Petri, Bojan Bister und Daniel Bischoff für Unterstützung bei den Analysen. )

Autor: Steffen Weik, Jörg Rademann

Publikováno v: Angewandte Chemie; Jun2003, Vol. 115 Issue 22, p2595-2598, 4p

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Effect of endogenous multidrug resistance 1 and P-glycoprotein expression on anticancer drug resistance in colon cancer cell lines

Autor: Ikumi Tamai, Naoki Ishiguro, Takeo Nakanishi, Ikumi Washio, Bojan Bister

Publikováno v: Biopharmaceuticsdrug disposition. 40(1)

P-glycoprotein (P-gp, multidrug resistance 1 (MDR1)) overexpression confers multidrug resistance to cancer cells, and P-gp in cell lines transfected with MDR1 or selected with chemotherapeutics significantly affect the anticancer drug efficacy. Altho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::808dc7b6f4eedd2a2f2276553f28557f
https://pubmed.ncbi.nlm.nih.gov/30556139

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