Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Bojan Žagrović"'
Autor:
Fanny Kozak, Dörte Brandis, Christopher Pötzl, Ludovica M. Epasto, Daniela Reichinger, Dominik Obrist, Herwig Peterlik, Anton Polyansky, Bojan Zagrovic, Fabian Daus, Armin Geyer, Christian FW Becker, Dennis Kurzbach
Publikováno v:
Advanced Science, Vol 11, Iss 30, Pp n/a-n/a (2024)
Abstract Deciphering nature's remarkable way of encoding functions in its biominerals holds the potential to enable the rational development of nature‐inspired materials with tailored properties. However, the complex processes that convert solution
Externí odkaz:
https://doaj.org/article/0b957a1634a14f3ba896d38e883105fc
Autor:
Johannes Benedum, Vedran Franke, Lisa-Marie Appel, Lena Walch, Melania Bruno, Rebecca Schneeweiss, Juliane Gruber, Helena Oberndorfer, Emma Frank, Xué Strobl, Anton Polyansky, Bojan Zagrovic, Altuna Akalin, Dea Slade
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)
Abstract Transcription is regulated by a multitude of activators and repressors, which bind to the RNA polymerase II (Pol II) machinery and modulate its progression. Death-inducer obliterator 3 (DIDO3) and PHD finger protein 3 (PHF3) are paralogue pr
Externí odkaz:
https://doaj.org/article/7e2958cf4ca145b5b98cf2019cfa7806
Autor:
David Flores-Solis, Irina P. Lushpinskaia, Anton A. Polyansky, Arya Changiarath, Marc Boehning, Milana Mirkovic, James Walshe, Lisa M. Pietrek, Patrick Cramer, Lukas S. Stelzl, Bojan Zagrovic, Markus Zweckstetter
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Eukaryotic gene regulation and pre-mRNA transcription depend on the carboxy-terminal domain (CTD) of RNA polymerase (Pol) II. Due to its highly repetitive, intrinsically disordered sequence, the CTD enables clustering and phase separation of
Externí odkaz:
https://doaj.org/article/d764f11023754998bb583c1d63ee30b3
Autor:
Lisa-Marie Appel, Vedran Franke, Johannes Benedum, Irina Grishkovskaya, Xué Strobl, Anton Polyansky, Gregor Ammann, Sebastian Platzer, Andrea Neudolt, Anna Wunder, Lena Walch, Stefanie Kaiser, Bojan Zagrovic, Kristina Djinovic-Carugo, Altuna Akalin, Dea Slade
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-22 (2023)
Here the authors establish the SPOC domain as a universal reader of the RNA Pol II CTD code and a versatile reader of phosphoserine marks found in co- and post-transcriptional regulators such as m6A writer and reader proteins.
Externí odkaz:
https://doaj.org/article/c385ebe5d8ab489ea14decc0dad9379b
Publikováno v:
eLife, Vol 12 (2023)
Non-membrane-bound biomolecular condensates have been proposed to represent an important mode of subcellular organization in diverse biological settings. However, the fundamental principles governing the spatial organization and dynamics of condensat
Externí odkaz:
https://doaj.org/article/da8784a061cf4a859883f540bbe1a9e0
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract Covalent modifications of standard DNA/RNA nucleobases affect epigenetic regulation of gene expression by modulating interactions between nucleic acids and protein readers. We derive here the absolute binding free energies and analyze the bi
Externí odkaz:
https://doaj.org/article/975e9e4bea79405f91e06d79495cd210
Publikováno v:
Life, Vol 4, Iss 4, Pp 788-799 (2014)
Early-stage evolutionary development of the universal genetic code remains a fundamental, open problem. One of the possible scenarios suggests that the code evolved in response to direct interactions between peptides and RNA oligonucleotides in the p
Externí odkaz:
https://doaj.org/article/d95cb121ea924aa29d476d0b50c4dc1b
Autor:
Lukas Bartonek, Bojan Zagrovic
Publikováno v:
PLoS Computational Biology, Vol 13, Iss 7, p e1005648 (2017)
It has recently been demonstrated that the nucleobase-density profiles of mRNA coding sequences are related in a complementary manner to the nucleobase-affinity profiles of their cognate protein sequences. Based on this, it has been proposed that cog
Externí odkaz:
https://doaj.org/article/f6cc7e41439c46f299e58a42d973097b
Autor:
Dorotea Fracchiolla, Justyna Sawa-Makarska, Bettina Zens, Anita de Ruiter, Gabriele Zaffagnini, Andrea Brezovich, Julia Romanov, Kathrin Runggatscher, Claudine Kraft, Bojan Zagrovic, Sascha Martens
Publikováno v:
eLife, Vol 5 (2016)
Selective autophagy is mediated by cargo receptors that link the cargo to the isolation membrane via interactions with Atg8 proteins. Atg8 proteins are localized to the membrane in an ubiquitin-like conjugation reaction, but how this conjugation is c
Externí odkaz:
https://doaj.org/article/9e792a1fdaea4938bbb493df72516559
Autor:
Drazen Petrov, Bojan Zagrovic
Publikováno v:
PLoS Computational Biology, Vol 10, Iss 5, p e1003638 (2014)
The high concentration of macromolecules in the crowded cellular interior influences different thermodynamic and kinetic properties of proteins, including their structural stabilities, intermolecular binding affinities and enzymatic rates. Moreover,
Externí odkaz:
https://doaj.org/article/7679953f98ed4d5a9d411c383742a757