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Akademický článek

Machine learning-based high-frequency neuronal spike reconstruction from low-frequency and low-sampling-rate recordings

Autor: Nari Hong, Boil Kim, Jaewon Lee, Han Kyoung Choe, Kyong Hwan Jin, Hongki Kang

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)

Abstract Recording neuronal activity using multiple electrodes has been widely used to understand the functional mechanisms of the brain. Increasing the number of electrodes allows us to decode more variety of functionalities. However, handling massi

Externí odkaz: https://doaj.org/article/e31eff40ea894d7b80c6c19687471af2

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Akademický článek

Presenilin 2 N141I mutation induces hyperactive immune response through the epigenetic repression of REV-ERBα

Autor: Hyeri Nam, Younghwan Lee, Boil Kim, Ji-Won Lee, Seohyeon Hwang, Hyun-Kyu An, Kyung Min Chung, Youngjin Park, Jihyun Hong, Kyungjin Kim, Eun-Kyoung Kim, Han Kyoung Choe, Seong-Woon Yu

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)

Hyperimmunity is associated with Alzheimer disease. Here the authors show that the Presenilin 2 N141I mutation causes overproduction of clock-controlled cytokines and memory deficits through suppression of REV-ERBα gene by hypermethylation.

Externí odkaz: https://doaj.org/article/0891987c94e34fc195c560af5e513f1b

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Akademický článek

Multiplexed CRISPR-Cas9 system in a single adeno-associated virus to simultaneously knock out redundant clock genes

Autor: Boil Kim, Jihoon Kim, Minjeong Chun, Inah Park, Damhyeon Kwak, Mijung Choi, Kyungjin Kim, Han Kyoung Choe

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)

Abstract The mammalian molecular clock is based on a transcription-translation feedback loop (TTFL) comprising the Period1, 2 (Per1, 2), Cryptochrome1, 2 (Cry1, 2), and Brain and Muscle ARNT-Like 1 (Bmal1) genes. The robustness of the TTFL is attribu

Externí odkaz: https://doaj.org/article/1542793254f346c39d8097beb11fb52d

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Long-term

Autor: Jae-Won, Jang, Yoo Na, Kang, Hee Won, Seo, Boil, Kim, Han Kyoung, Choe, Sang Hyun, Park, Maan-Gee, Lee, Sohee, Kim

Publikováno v: Journal of neural engineering. 18(6)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3e2ba61464f7c405e560a878bdddcba4
https://pubmed.ncbi.nlm.nih.gov/34795067

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Multiplexed CRISPR-Cas9 system in a single adeno-associated virus to simultaneously knock out redundant clock genes

Autor: Inah Park, Mijung Choi, Boil Kim, Minjeong Chun, Kyungjin Kim, Han Kyoung Choe, Damhyeon Kwak, Jihoon Kim

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Scientific Reports

The mammalian molecular clock is based on a transcription-translation feedback loop (TTFL) comprising the Period1, 2 (Per1, 2), Cryptochrome1, 2 (Cry1, 2), and Brain and Muscle ARNT-Like 1 (Bmal1) genes. The robustness of the TTFL is attributed to ge

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::146d9215dba5ab0f3b47cd7edd497b93
https://doi.org/10.1038/s41598-021-82287-0

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Presenilin 2 N141I mutation induces hyperactive immune response through the epigenetic repression of REV-ERBα

Autor: Young Hwan Lee, Eunkyoung Kim, Jihyun Hong, Han Kyoung Choe, Hyun-Kyu An, Ji-Won Lee, Kyung Min Chung, Young-Jin Park, Boil Kim, Hyeri Nam, Kyungjin Kim, Seong-Woon Yu

Hyperimmunity drives the development of Alzheimer disease (AD). The immune system is under the circadian control, and circadian abnormalities aggravate AD progress. Here, we investigated how an AD-linked mutation deregulates expression of circadian g

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::67df935463213bab9d012f19db58e6e0
https://doi.org/10.21203/rs.3.rs-102825/v1

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Single adeno-associated virus-based multiplexed CRISPR-Cas9 system to nullify core components of the mammalian molecular clock

Autor: Minjeong Chun, Inah Park, Han Kyoung Choe, Boil Kim, Jihoon Kim, Mijung Choi, Kyungjin Kim

The mammalian molecular clock is based on a transcription-translation feedback loop (TTFL) containing Period1, 2 (Per1, 2), Cryptochrome1, 2 (Cry1, 2), and Brain and Muscle ARNT-Like 1 (Bmal1). TTFL robustness is endowed by genetic complementation be

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e59c396d7c3e0bd5a2e6b6e793e57f99
https://doi.org/10.1101/2020.07.02.184119

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Long-term in-vivo recording performance of flexible penetrating microelectrode arrays

Autor: Sohee Kim, Han Kyoung Choe, Boil Kim, Jae-Won Jang, Maan-Gee Lee, Hee Won Seo, Sang Hyun Park, Yoo Na Kang

Publikováno v: Journal of Neural Engineering. 18:066018

Objective. Neural interfaces are an essential tool to enable the human body to directly communicate with machines such as computers or prosthetic robotic arms. Since invasive electrodes can be located closer to target neurons, they have advantages su

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e8ce5c815cd740d60fc727f1100a592e
https://doi.org/10.1088/1741-2552/ac3656

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